慢性间歇性低氧导致认知障碍的细胞机制研究进展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

黄惠嫦 ^1,2,3,4 , 文依宁 ^1,2,3,5 ,  梁新 ^2,6 ,  赵明明 ^1,2,3

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Corresponding author：

梁新, Email: gxyyliangxin@sina.com; 赵明明, Email: topabigale@163.com

Keywords：

DOI：

10.7507/1671-6205.202405114

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Citation： 黄惠嫦, 文依宁, 梁新, 赵明明. 慢性间歇性低氧导致认知障碍的细胞机制研究进展. Chinese Journal of Respiratory and Critical Care Medicine, 2025, 24(3): 218-224. doi: 10.7507/1671-6205.202405114 Copy

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2. Rae C, Bartlett DJ, Yang Q, et al. Dynamic changes in brain bioenergetics during obstructive sleep apnea. J Cereb Blood Flow Metab, 2009, 29(8): 1421-1428.
3. Mubashir T, Abrahamyan L, Niazi A, et al. The prevalence of obstructive sleep apnea in mild cognitive impairment: a systematic review. BMC Neurol, 2019, 19(1): 195.
4. 覃丽霞, 钟清清, 陆怡安, 等. 老年阻塞性睡眠呼吸暂停合并认知功能障碍患者睡眠及脑功能状态特点. 中国临床新医学, 2024, 17(1): 12-18.
5. 何权瀛. 阻塞性睡眠呼吸暂停综合征何权瀛2022观点. 第1版. 北京: 科学技术文献出版社, 2022: 28-43.
6. Macey PM, Henderson LA, Macey KE, et al. Brain morphology associated with obstructive sleep apnea. Am J Respir Crit Care Med, 2002, 166(10): 1382-1387.
7. 沈煜斌, 欧茜文, 刘松. 阻塞性睡眠呼吸暂停对脑代谢功能的影响. 中国呼吸与危重监护杂志, 2024, 23(2): 132-137.
8. Yang Q, Wang Y, Feng J, et al. Intermittent hypoxia from obstructive sleep apnea may cause neuronal impairment and dysfunction in central nervous system: the potential roles played by microglia. Neuropsychiatr Dis Treat, 2013, 9: 1077-1086.
9. Nair D, Ramesh V, Li RC, et al. Growth hormone releasing hormone (GHRH) signaling modulates intermittent hypoxia-induced oxidative stress and cognitive deficits in mouse. J Neurochem, 2013, 127(4): 531-540.
10. Aviles-Reyes RX, Angelo MF, Villarreal A, et al. Intermittent hypoxia during sleep induces reactive gliosis and limited neuronal death in rats: implications for sleep apnea. J Neurochem, 2010, 112(4): 854-869.
11. Lewén A, Matz P, Chan PH. Free radical pathways in CNS injury. J Neurotrauma, 2000, 17(10): 871-890.
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慢性间歇性低氧导致认知障碍的细胞机制研究进展

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