脑电图在慢性呼吸系统疾病中的应用价值及研究进展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

刘欣蕊 ¹ , 倪夕秀 ¹ , 陈颖 ¹ , 杨佐琴 ² ,  赵凌 ¹

1. ;
2. ;

Corresponding author：

赵凌, Email: zhaoling@cdutcm.edu.cn

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DOI：

10.7507/1671-6205.202410036

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Citation： 刘欣蕊, 倪夕秀, 陈颖, 杨佐琴, 赵凌. 脑电图在慢性呼吸系统疾病中的应用价值及研究进展. Chinese Journal of Respiratory and Critical Care Medicine, 2025, 24(3): 212-217. doi: 10.7507/1671-6205.202410036 Copy

1.	朱衣兴, 常德. 慢性呼吸系统疾病管理的现状和展望. 结核与肺部疾病杂志, 2024, 5(6): 567-572.
2.	Dodd JW, Charlton RA. Cognitive dysfunction in patients hospitalized with acute exacerbation of COPD. Chest, 2013, 144(1): 119-127.
3.	Areza-Fegyveres R, Kairalla RA. Cognition and chronic hypoxia in pulmonary diseases. Dement Neuropsychol, 2010, 4(1): 14-22.
4.	Fan VS, Meek PM. Anxiety, depression, and cognitive impairment in patients with chronic respiratory disease. Clin Chest Med, 2014, 35(2): 399-409.
5.	陈琰, 钱频, 袁琳等. 慢性阻塞性肺疾病肺外合并症的治疗现状和研究进展. 中华肺部疾病杂志(电子版), 2020, 13(1): 100-103.
6.	Similowski T. Treat the lungs, fool the brain and appease the mind: towards holistic care of patients who suffer from chronic respiratory diseases. Eur Respir J, 2018, 51(2): 1800316.
7.	Janssens T, De Peuter S, Stans L, et al. Dyspnea perception in COPD: Association between anxiety, dyspnea-related fear, and dyspnea in a pulmonary rehabilitation program. Chest, 2011, 140(3): 618-625.
8.	岳丹, 罗志梅, 范林婕, 等. 手持风扇疗法在缓解呼吸困难中的研究现状. 中国呼吸与危重监护杂志, 2024, 23(8): 605-608.
9.	王玮. 慢性阻塞性肺疾病患者脑功能及结构网络变化的MRI研究. 中国人民解放军海军军医大学, 2021.
10.	Finnegan SL, Harrison OK, Harmer CJ, et al. Breathlessness in COPD: linking symptom clusters with brain activity. Eur Respir J, 2021, 58(5): 2004099.
11.	Wang M, Wang Y, Wang Z, et al. The abnormal alternations of brain imaging in patients with chronic obstructive pulmonary disease: a systematic review. J Alzheimers Dis Rep, 2023(1): 901-919.
12.	Nunez PL, Srinivasan R. A theoretical basis for standing and traveling brain waves measured with human EEG with implications for an integrated consciousness. Clin Neurophysiol, 2006, 17(11): 2424-35.
13.	郑贝思, 陈健尔. 定量脑电图在认知功能障碍康复中的应用研究进展. 中华物理医学与康复杂志, 2024, 46(8): 764-768.
14.	覃慧怡, 丁丽洪, 段威, 等. 脑电的重测信度: 在多项静息态和任务态实验中的对比. 心理学报, 2023, 55(10): 1587-1596.
15.	段宏霞, 刘沁欣, 赵仙丽, 等. 认知功能评价工具在慢性阻塞性肺疾病中的应用进展. 中国康复医学杂志, 2023, 38(4): 539-545.
16.	何晓燕, 朱沂, 李红燕, 等. 痴呆评估量表与事件相关电位P300对轻度认知功能障碍患者认知功能的评价. 中国老年学杂志, 2011, 31(16): 3041-3043.
17.	陈甄, 张广波, 周迪, 等. 急性高原低氧环境对不同情绪状态脑电功率的影响. 中国应用生理学杂志, 2020, 36(6): 556-561.
18.	聂聃, 王晓韡, 段若男, 等. 基于脑电的情绪识别研究综述. 中国生物医学工程学报, 2012, 31(4): 595-606.
19.	Zhuang N, Zeng Y, Tong L, et al. Emotion recognition from eeg signals using multidimensional information in EMD domain. Biomed Res Int, 2017, 2017: 8317357.
20.	陈旭东, 钟恒, 皇甫洁, 等. 脑电信号情绪识别综述. 计算机应用, 2023, 43(S1): 323-332.
21.	Wang T, Mao L, Wang J, et al. Influencing factors and exercise intervention of cognitive impairment in elderly patients with chronic obstructive pulmonary disease. Clin Interv Aging, 2020, 15: 557-566.
22.	Li QY, Li XM, Hu HY, et al. Associations of lung function decline with risks of cognitive impairment and dementia: a meta-analysis and systematic review. J Alzheimers Dis, 2023, 92(3): 853-873.
23.	Medvidovic S, Titlic M, Maras-Simunic M. P300 evoked potential in patients with mild cognitive impairment. Acta Inform Med, 2013, 21(2): 89-92.
24.	Krishnamurthy S, Sivagnaname Y, Gumallapu GC. Identification of subclinical cognitive impairment in chronic obstructive pulmonary disease using auditory P300 event related potential. Monaldi Arch Chest Dis, 2019, 89(2).
25.	于雅洁, 张新安. 太极拳运动对COPD-OSAHS重叠综合征患者认知电位p300及肺通气功能的影响. 沈阳体育学院学报, 2019, 38(5): 91-97.
26.	Van Dinteren R, et al. P300 development across the lifespan: a systematic review and meta-analysis. PloS One, 2014, 9(2): e87347.
27.	Tselebis A, Pachi A, Ilias I, et al. Strategies to improve anxiety and depression in patients with COPD: a mental health perspective. Neuropsychiatr Dis Treat, 2016, 12: 297-328.
28.	Pooler A, Beech R. Examining the relationship between anxiety and depression and exacerbations of COPD which result in hospital admission: a systematic review. Int J Chron Obstruct Pulmon Dis, 2014, 9: 315-30.
29.	Pierobon A, et al. Screening for neuropsychological impairment in COPD patients undergoing rehabilitation. PLoS One, 2018, 13(8): e0199736.
30.	Anonymous. Automated diagnosis of depression from EEG signals using traditional and deep learning approaches: a comparative analysis. Biocybern Biomed Eng, 2022, 42(1): 108-142.
31.	De Aguiar Neto FS, Rosa JLG. Depression biomarkers using non-invasive EEG: A review. Neurosci Biobehav Rev, 2019, 105: 83-93.
32.	Fitzgerald PJ, Watson BO. Gamma oscillations as a biomarker for major depression: an emerging topic. Transl Psychiatry, 2018, 8(1): 177.
33.	Muhammad F. Human state anxiety classification framework using EEG signals in response to exposure therapy. PLoS One, 2022, 17(3): e0265679.
34.	王亚茹. OSAHS患者睡眠参数变化与焦虑抑郁及认知障碍的关系. 吉林大学, 2023.
35.	Markiewcz R. The use of EEG Biofeedback/Neurofeedback in psychiatric rehabilitation. Psychiatr Pol, 2017, 51(6): 1095-1106. English, Polish.
36.	Hou Y, Zhang S, Li N, et al. Neurofeedback training improves anxiety trait and depressive symptom in GAD. Brain Behav, 2021, 11(3): e02024.
37.	Loriette C, et al. Neurofeedback for cognitive enhancement and intervention and brain plasticity. Rev Neurol (Paris), 2021, 177(9): 1133-1144.
38.	马文, 邹涛, 等. 脑电生物反馈治疗对老年慢性阻塞性肺疾病患者情绪及睡眠状况的影响. 贵州医科大学学报, 2022, 47(5): 576-580.
39.	王晶波, 杨静玲, 王鑫. 肺性脑病中西医治疗现状与研究进展. 辽宁中医杂志, 2023, 50(2): 216-220.
40.	石金荣. 脑电图在肺性脑病诊断中的价值. 华北煤炭医学院学报, 2002, 4(2): 199.
41.	曹政红, 费世早. 肺性脑病脑电图的临床应用分析. 皖南医学院学报, 2015, 34(3): 244-246.
42.	李艳红. 32例肺性脑病脑电图动态观察. 临床医学, 2010, 30(4): 70-71.
43.	Schmidt M, Demoule A, Polito A, et al. Dyspnea in mechanically ventilated critically ill patients. Crit Care Med, 2011, 39(9): 2059-65.
44.	Decavèle M, et al. Detection and management of dyspnea in mechanically ventilated patients. Curr Opin Crit Care, 2019, 25(1): 86-94.
45.	Raux M, Straus C, Redolfi S, et al. Electroencephalographic evidence for pre-motor cortex activation during inspiratory loading in humans. J Physiol, 2007, 578(Pt 2): 569-578.
46.	Raux M, Ray P, Prella M, et al. Cerebral cortex activation during experimentally induced ventilator fighting in normal humans receiving noninvasive mechanical ventilation. Anesthesiology, 2007, 107(5): 746-755.
47.	Navarro-Sune X, et al. Riemannian Geometry applied to detection of respiratory states from EEG signals: the basis for a brain-ventilator interface. IEEE Trans Biomed Eng, 2017, 64(5): 1138-1148.
48.	陈柏茹, 陈贵华, 李琴. COPD患者认知功能障碍影响因素模型研究. 现代医药卫生, 2022, 38(10): 1639-1644,1649.
49.	王卫红, 何国平, 等. 阻塞性睡眠呼吸暂停低通气综合征患者认知功能与焦虑情绪相关研究. 中国全科医学, 2012, 15(13): 1513-1515.
50.	宋雨, 刘杨, 高强, 等. 基于脑电多域特征融合的跨任务认知负荷研究. 实验技术与管理, 2024, 41(2): 73-80.
51.	李铮, 陈欣, 树海峰. 负面情绪的脑电特征及功能连接环路的研究进展. 东南国防医药, 2023, 25(3): 307-311.
52.	李晓华, 高磊, 于可君. 基于图论的不同情绪状态下脑网络功能连接研究. 医疗卫生装备, 2023, 44(11): 9-14.
53.	Dimitrakopoulos GN, Kakkos I, Dai Z, et al. Task-independent mental workload classification based upon common multiband eeg cortical connectivity. IEEE Trans Neural Syst Rehabil Eng, 2017, 25(11): 1940-1949.
54.	刘淑玲. 阻塞性睡眠呼吸暂停低通气综合征患者合并情绪障碍的临床及脑电活动特征. 苏州大学, 2024.
55.	Noble MI, Frankel HL, Else W, et al. The ability of man to detect added resistive loads to breathing. Clin Sci, 1971, 41(3): 285-7.
56.	Von Leupoldt A, et al. Emotions and neural processing of respiratory sensations investigated with respiratory-related evoked potentials. Psychosom Med, 2013, 75(3): 244-52.
57.	Von Leupoldt A, et al. The impact of emotion on respiratory-related evoked potentials. Psychophysiology, 2010, 47(3): 579-586.
58.	Reijnders T, Troosters T, Janssens W, et al. Brain activations to dyspnea in patients with COPD. Front Physiol, 2020, 11: 7.
59.	Hammond CS, et al. Respiratory-related evoked potential elicited by expiratory occlusion. J Appl Physiol (1985), 1999, 87(2): 835-842.
60.	刘潇雅, 刘爽, 郭冬月, 等. 抑郁症脑电特异性研究进展. 中国生物医学工程学报, 2020, 39(3): 351-361.
61.	贾天宇, 钱超, 李翀, 等. 基于个性化导联选择策略的脑机交互康复训练临床初步研究. 清华大学学报(自然科学版), 2020, 60(11): 920-926.

1. 朱衣兴, 常德. 慢性呼吸系统疾病管理的现状和展望. 结核与肺部疾病杂志, 2024, 5(6): 567-572.
2. Dodd JW, Charlton RA. Cognitive dysfunction in patients hospitalized with acute exacerbation of COPD. Chest, 2013, 144(1): 119-127.
3. Areza-Fegyveres R, Kairalla RA. Cognition and chronic hypoxia in pulmonary diseases. Dement Neuropsychol, 2010, 4(1): 14-22.
4. Fan VS, Meek PM. Anxiety, depression, and cognitive impairment in patients with chronic respiratory disease. Clin Chest Med, 2014, 35(2): 399-409.
5. 陈琰, 钱频, 袁琳等. 慢性阻塞性肺疾病肺外合并症的治疗现状和研究进展. 中华肺部疾病杂志(电子版), 2020, 13(1): 100-103.
6. Similowski T. Treat the lungs, fool the brain and appease the mind: towards holistic care of patients who suffer from chronic respiratory diseases. Eur Respir J, 2018, 51(2): 1800316.
7. Janssens T, De Peuter S, Stans L, et al. Dyspnea perception in COPD: Association between anxiety, dyspnea-related fear, and dyspnea in a pulmonary rehabilitation program. Chest, 2011, 140(3): 618-625.
8. 岳丹, 罗志梅, 范林婕, 等. 手持风扇疗法在缓解呼吸困难中的研究现状. 中国呼吸与危重监护杂志, 2024, 23(8): 605-608.
9. 王玮. 慢性阻塞性肺疾病患者脑功能及结构网络变化的MRI研究. 中国人民解放军海军军医大学, 2021.
10. Finnegan SL, Harrison OK, Harmer CJ, et al. Breathlessness in COPD: linking symptom clusters with brain activity. Eur Respir J, 2021, 58(5): 2004099.
11. Wang M, Wang Y, Wang Z, et al. The abnormal alternations of brain imaging in patients with chronic obstructive pulmonary disease: a systematic review. J Alzheimers Dis Rep, 2023(1): 901-919.
12. Nunez PL, Srinivasan R. A theoretical basis for standing and traveling brain waves measured with human EEG with implications for an integrated consciousness. Clin Neurophysiol, 2006, 17(11): 2424-35.
13. 郑贝思, 陈健尔. 定量脑电图在认知功能障碍康复中的应用研究进展. 中华物理医学与康复杂志, 2024, 46(8): 764-768.
14. 覃慧怡, 丁丽洪, 段威, 等. 脑电的重测信度: 在多项静息态和任务态实验中的对比. 心理学报, 2023, 55(10): 1587-1596.
15. 段宏霞, 刘沁欣, 赵仙丽, 等. 认知功能评价工具在慢性阻塞性肺疾病中的应用进展. 中国康复医学杂志, 2023, 38(4): 539-545.
16. 何晓燕, 朱沂, 李红燕, 等. 痴呆评估量表与事件相关电位P300对轻度认知功能障碍患者认知功能的评价. 中国老年学杂志, 2011, 31(16): 3041-3043.
17. 陈甄, 张广波, 周迪, 等. 急性高原低氧环境对不同情绪状态脑电功率的影响. 中国应用生理学杂志, 2020, 36(6): 556-561.
18. 聂聃, 王晓韡, 段若男, 等. 基于脑电的情绪识别研究综述. 中国生物医学工程学报, 2012, 31(4): 595-606.
19. Zhuang N, Zeng Y, Tong L, et al. Emotion recognition from eeg signals using multidimensional information in EMD domain. Biomed Res Int, 2017, 2017: 8317357.
20. 陈旭东, 钟恒, 皇甫洁, 等. 脑电信号情绪识别综述. 计算机应用, 2023, 43(S1): 323-332.
21. Wang T, Mao L, Wang J, et al. Influencing factors and exercise intervention of cognitive impairment in elderly patients with chronic obstructive pulmonary disease. Clin Interv Aging, 2020, 15: 557-566.
22. Li QY, Li XM, Hu HY, et al. Associations of lung function decline with risks of cognitive impairment and dementia: a meta-analysis and systematic review. J Alzheimers Dis, 2023, 92(3): 853-873.
23. Medvidovic S, Titlic M, Maras-Simunic M. P300 evoked potential in patients with mild cognitive impairment. Acta Inform Med, 2013, 21(2): 89-92.
24. Krishnamurthy S, Sivagnaname Y, Gumallapu GC. Identification of subclinical cognitive impairment in chronic obstructive pulmonary disease using auditory P300 event related potential. Monaldi Arch Chest Dis, 2019, 89(2).
25. 于雅洁, 张新安. 太极拳运动对COPD-OSAHS重叠综合征患者认知电位p300及肺通气功能的影响. 沈阳体育学院学报, 2019, 38(5): 91-97.
26. Van Dinteren R, et al. P300 development across the lifespan: a systematic review and meta-analysis. PloS One, 2014, 9(2): e87347.
27. Tselebis A, Pachi A, Ilias I, et al. Strategies to improve anxiety and depression in patients with COPD: a mental health perspective. Neuropsychiatr Dis Treat, 2016, 12: 297-328.
28. Pooler A, Beech R. Examining the relationship between anxiety and depression and exacerbations of COPD which result in hospital admission: a systematic review. Int J Chron Obstruct Pulmon Dis, 2014, 9: 315-30.
29. Pierobon A, et al. Screening for neuropsychological impairment in COPD patients undergoing rehabilitation. PLoS One, 2018, 13(8): e0199736.
30. Anonymous. Automated diagnosis of depression from EEG signals using traditional and deep learning approaches: a comparative analysis. Biocybern Biomed Eng, 2022, 42(1): 108-142.
31. De Aguiar Neto FS, Rosa JLG. Depression biomarkers using non-invasive EEG: A review. Neurosci Biobehav Rev, 2019, 105: 83-93.
32. Fitzgerald PJ, Watson BO. Gamma oscillations as a biomarker for major depression: an emerging topic. Transl Psychiatry, 2018, 8(1): 177.
33. Muhammad F. Human state anxiety classification framework using EEG signals in response to exposure therapy. PLoS One, 2022, 17(3): e0265679.
34. 王亚茹. OSAHS患者睡眠参数变化与焦虑抑郁及认知障碍的关系. 吉林大学, 2023.
35. Markiewcz R. The use of EEG Biofeedback/Neurofeedback in psychiatric rehabilitation. Psychiatr Pol, 2017, 51(6): 1095-1106. English, Polish.
36. Hou Y, Zhang S, Li N, et al. Neurofeedback training improves anxiety trait and depressive symptom in GAD. Brain Behav, 2021, 11(3): e02024.
37. Loriette C, et al. Neurofeedback for cognitive enhancement and intervention and brain plasticity. Rev Neurol (Paris), 2021, 177(9): 1133-1144.
38. 马文, 邹涛, 等. 脑电生物反馈治疗对老年慢性阻塞性肺疾病患者情绪及睡眠状况的影响. 贵州医科大学学报, 2022, 47(5): 576-580.
39. 王晶波, 杨静玲, 王鑫. 肺性脑病中西医治疗现状与研究进展. 辽宁中医杂志, 2023, 50(2): 216-220.
40. 石金荣. 脑电图在肺性脑病诊断中的价值. 华北煤炭医学院学报, 2002, 4(2): 199.
41. 曹政红, 费世早. 肺性脑病脑电图的临床应用分析. 皖南医学院学报, 2015, 34(3): 244-246.
42. 李艳红. 32例肺性脑病脑电图动态观察. 临床医学, 2010, 30(4): 70-71.
43. Schmidt M, Demoule A, Polito A, et al. Dyspnea in mechanically ventilated critically ill patients. Crit Care Med, 2011, 39(9): 2059-65.
44. Decavèle M, et al. Detection and management of dyspnea in mechanically ventilated patients. Curr Opin Crit Care, 2019, 25(1): 86-94.
45. Raux M, Straus C, Redolfi S, et al. Electroencephalographic evidence for pre-motor cortex activation during inspiratory loading in humans. J Physiol, 2007, 578(Pt 2): 569-578.
46. Raux M, Ray P, Prella M, et al. Cerebral cortex activation during experimentally induced ventilator fighting in normal humans receiving noninvasive mechanical ventilation. Anesthesiology, 2007, 107(5): 746-755.
47. Navarro-Sune X, et al. Riemannian Geometry applied to detection of respiratory states from EEG signals: the basis for a brain-ventilator interface. IEEE Trans Biomed Eng, 2017, 64(5): 1138-1148.
48. 陈柏茹, 陈贵华, 李琴. COPD患者认知功能障碍影响因素模型研究. 现代医药卫生, 2022, 38(10): 1639-1644,1649.
49. 王卫红, 何国平, 等. 阻塞性睡眠呼吸暂停低通气综合征患者认知功能与焦虑情绪相关研究. 中国全科医学, 2012, 15(13): 1513-1515.
50. 宋雨, 刘杨, 高强, 等. 基于脑电多域特征融合的跨任务认知负荷研究. 实验技术与管理, 2024, 41(2): 73-80.
51. 李铮, 陈欣, 树海峰. 负面情绪的脑电特征及功能连接环路的研究进展. 东南国防医药, 2023, 25(3): 307-311.
52. 李晓华, 高磊, 于可君. 基于图论的不同情绪状态下脑网络功能连接研究. 医疗卫生装备, 2023, 44(11): 9-14.
53. Dimitrakopoulos GN, Kakkos I, Dai Z, et al. Task-independent mental workload classification based upon common multiband eeg cortical connectivity. IEEE Trans Neural Syst Rehabil Eng, 2017, 25(11): 1940-1949.
54. 刘淑玲. 阻塞性睡眠呼吸暂停低通气综合征患者合并情绪障碍的临床及脑电活动特征. 苏州大学, 2024.
55. Noble MI, Frankel HL, Else W, et al. The ability of man to detect added resistive loads to breathing. Clin Sci, 1971, 41(3): 285-7.
56. Von Leupoldt A, et al. Emotions and neural processing of respiratory sensations investigated with respiratory-related evoked potentials. Psychosom Med, 2013, 75(3): 244-52.
57. Von Leupoldt A, et al. The impact of emotion on respiratory-related evoked potentials. Psychophysiology, 2010, 47(3): 579-586.
58. Reijnders T, Troosters T, Janssens W, et al. Brain activations to dyspnea in patients with COPD. Front Physiol, 2020, 11: 7.
59. Hammond CS, et al. Respiratory-related evoked potential elicited by expiratory occlusion. J Appl Physiol (1985), 1999, 87(2): 835-842.
60. 刘潇雅, 刘爽, 郭冬月, 等. 抑郁症脑电特异性研究进展. 中国生物医学工程学报, 2020, 39(3): 351-361.
61. 贾天宇, 钱超, 李翀, 等. 基于个性化导联选择策略的脑机交互康复训练临床初步研究. 清华大学学报(自然科学版), 2020, 60(11): 920-926.

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脑电图在慢性呼吸系统疾病中的应用价值及研究进展

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