The construction of national regional medical center is an important measure for expanding high-quality medical resources and achieving balanced regional distribution. Combining the construction experience of West China Hospital of Sichuan University as an output hospital for national regional medical center, this paper takes the construction project of West China Xiamen Hospital of Sichuan University as the breakthrough point, sorts out the three major dilemmas faced by new project hospital, including pre-operational pressure, dilution of output hospital resources, and regional differences in management systems. It innovatively proposes to strengthen the four main responsibility subjects: the newly built hospital, the output hospital, the local government, and the national level, and provides specific implementation strategy suggestions for 11 core matters, including differentiated development, multi-dimensional publicity, internal management, top-level design, information technology support, personnel subjective initiative, internal responsibility, policy guarantee, compensation mechanism, and assessment subjects.