目的:探讨幽门螺杆菌(Hp)感染与各种常见上消化道疾病的关系。 方法:回顾性地分析了2008年于我院采用快速尿素酶试验(RUT)检测Hp的6636例门诊及住院患者Hp感染情况,及与性别、年龄、病种的关系。结果:6636例患者中,Hp阳性3248例,检出率为48.9%;其中男性4391例,检出率为49.97%,女性2 245例,检出率为46.9%,男性略高于女性,差异有统计学意义(Plt;0.05);20～29岁和30～39岁这两个年龄段Hp检出率最高,分别为58.4%和54.6%,lt;20岁Hp检出率最低(38.8%),各组间差异有统计学意义(Plt;0.01);各种常见的上消化道疾病,复合性溃疡和上消化道恶性肿瘤Hp检出率最高,分别为86.2%和84.1%,其次是幽门管溃疡和十二指肠溃疡,检出率分别为54.2%和51.9%,慢性胃炎、残胃炎、胃溃疡和食管静脉曲张Hp检出率分别为46.9%、40.0%、36.6%和34.2%,各组间的差异有显著的统计学意义(Plt;0.005)。 结论:本组资料Hp总检出率为48.9%,男性略高于女性,慢性胃炎、消化性溃疡和上消化道恶性肿瘤与Hp感染密切相关,尤以复合性溃疡和上消化道恶性肿瘤更为显著。
ObjectiveTo evaluate the weight loss outcomes, metabolic disease remission, and complication profiles of laparoscopic sleeve gastrectomy (LSG) based on a large single-center cohort experience. MethodsA retrospective observational study was conducted. Clinical data of patients who underwent LSG at Sir Run Run Shaw Hospital, Zhejiang University School of Medicine from June 2021 to June 2024 were collected based on predefined inclusion and exclusion criteria. The outcomes including percentage of total weight loss (%TWL), metabolic disease remission, and the incidence of postoperative complications were assessed. ResultsA total of 1 568 patients met the inclusion and exclusion criteria were finally included, including 304 males and 1 264 females. The age at surgery was (31.51±8.01）years old, and the body mass index was (37.26±4.18) kg/m2. At 1 year after surgery, the %TWL was (32.84±6.38)%, and the complete remission rate of diabetes was 96.2% (304/316). Complications within 1 year after surgery: 1 (0.06%) case of postoperative bleeding, 2 (0.13%) cases of gastric leakage, 1 (0.06%) case of vitamin B1 deficiency, and 1 (0.06%) case of unilateral common peroneal nerve entrapment injury. The total complication rate was 0.32% (5/1 568). No mortality was observed. ConclusionsLSG has significant short-term efficacy and higher safety in treatment of obesity and related metabolic diseases. In particular, experiences in aspects such as complication prevention and multidisciplinary follow-up management could provide references for centers in the early stage of development.