Psychological distress management can effectively reduce the incidence of psychological distress in female breast cancer patients, improve treatment adherence, and enhance quality of life. Healthcare professionals play a crucial role in the management of psychological distress among female breast cancer patients, and the development of practice guidelines tailored to the Chinese clinical context holds significant importance. This guideline addresses 13 key clinical questions related to the psychological distress management of female breast cancer patients and provides 27 recommendations. It aims to establish clinical standards for the standardized management of psychological distress, with the goal of improving treatment outcomes and quality of life for female breast cancer patients.