Objective The purpose of this study, which focuses on the number of the Cochrane Systematic Review’s (CSR) full texts, protocols and registered titles from Chinese authors, is to show the development of evidence-based medicine (EBM) and promote EBM’s further development in China. Methods On the basis of The Cochrane Library (Issue 1, 2009) and the Cochrane Collaboration (March 2009) periodicals, we performed statistical analysis of different countries that released CSR’s full texts, protocols and registered titles, as well as the time, authors and distribution of the CSR’s full texts, protocols and registered titles in China. Results The publishing rates of the CSR’s full texts, protocols and registered titles in China ranked the seventh, fifth and second, respectively. Although the number of CSR’s full texts and protocols showed an increased annual trend in China, the development of area distribution was unbalanced. Moreover, China’s published articles contained 47 Cochrane collaboration groups, without effective practice and health care groups, consumers and communication groups, and methodology and multiple stenosis groups. Conclusions The current Chinese EBM situation has a great potential in writing CSR. However, there are still many problems that need to be resolved.
Cochrane协作网（www.cochrane.org）是世界上最大的致力于制作、保存和提升卫生保健干预效果系统评价可及性的国际组织。它拥有100多个参与国，主要与负责制作和保存Cochrane系统评价的各Cochrane系统评价组相关。从2000年起，依靠散在各国的各Cochrane系统评价组活跃成员已完成系统评价的定期审核。至2010年初，协作网已从2000年约5 500人增加至近28 000人。Cochrane活动发展迅速，Cochrane系统评价和计划书的作者人数增长尤为突出。2000年，各Cochrane系统评价组有2 840个注册作者。到2010年初，注册作者数已升至21 000人以上。
Having searched The Cochrane Library (Issue 4, 2005), we found: fluoride can reduce the occurrence and severity of white spot lesions; removal of premature contacts of the primary teeth can prevent posterior crossbite; expanding the top teeth can decrease the risk of a posterior crossbite; CSF may help retaining teeth; clear overlay retainer may settle teeth quicker than Hawley retainer; adhesives for fixed orthodontic brackets is still in dispute.
ObjectiveTo investigate the extent of overlap between Chinese systematic reviews (SRs) and Cochrane SRs in the field of stroke. MethodsThe CNKI, WanFang Data, CBM and Cochrane Library databases were searched to collect Chinese SRs and Cochrane SRs in the field of stroke published from 2012 to 2022. By extracting population (P), intervention (I), comparison (C), and outcome (O) of all interventional SRs in the stroke field to analyse the extent of overlap of SRs. The basic information and research information of SRs with overlapping PICOs were further extracted to conduct descriptive analysis. ResultsA total of 1 303 SRs were included, involving 1 192 Chinese SRs and 111 Cochrane SRs in the field of stroke. The overlapping analysis found that 128 Chinese SRs overlapped with 29 (26.1%) of the 111 Cochrane SRs. Most (127/128, 99.2%) Chinese SRs were published later than Cochrane SRs. The year of publication of overlapping SRs showed a trend of increasing year by year. ConclusionThe SR work carried out by scholars in China has the problem of overlapping studies that cannot be ignored, and the lack of strict regulation and guidance in methods such as registration, protocol writing, and literature search has resulted in a great waste of resources. It is necessary to further strengthen regulatory constraints and guidance, adhere to problem orientation and quality awareness, strengthen SR training, and reduce overlapping research.
Background Tongxinluo capsule is a new drug for cardio- cerebral vascular diseases on the national essential drug list of China, and the second-class award of National Science and Technology Development of China, 2001. Objective This review aims to assess the effect (harms and benefits) of Tongxinluo capsule for unstable angina. Search strategy electronic searchs The Cochrane Heart Review Group specialised trials register,The Cochrane Controlled Trials Register, published in the latest issue of the Cochrane Library, MEDLINE, EMBASE, CBM, Chinese Cochrane Centre Controlled Trials Register, Current Controlled Trials (www. controlled-trials. com), The National Research Register Handsearchs We will search 83 journals of Chinese traditional medicine. Inclusion riteria We will include randomised controlled trials of Tonxinluo capsule versus placebo or other current phamarcotherapy or other Chinese medicinal herbs in the participants with unstable angina pectoris. Studies will report mortality (sudden death from acute myocardial infarction), severity of angina pectoris, frequency of acute attack angina, ECG improvement, rate of dosage reducing or taking frequency of nitroglycerine and symptom improvement, etc. Data analysis Data will be included in a meta-analysis if they are available, of sufficient quality and sufficiently similar.
In 1993 the Cochrane Collaboration, an international non-profit organization aiming at producing, updating and disseminating systematic reviews, was founded. Several years later, in 1999, the Chinese Cochrane centre opened in Chengdu, to provide support to (1) Chinese researchers willing to produce reviews and (2) politicians and practitioners willing to start using the results in daily practice. We searched PubMed and the database of the Chinese Cochrane Centre to retrieve data on the overall number of articles and reviews produced in the Chinese language for the period 1990 to 2006. Although the number of reviews increased substantially since the year 2000, the percentage of reviews in the overall number of articles indexed in PubMed remains modest.
Objective To explore the differences between large and small studies in rare events meta-analysis. Methods Empirical data were collected from The Cochrane Systematic Review Database from January 2003 to May 2018. Meta-analyses with rare events, binary outcomes involving at least 5 studies, and at least 1 large study were screened. Peto and classical ORs were used to compare the magnitude, direction and P-value. Results A total of 214 meta-analyses were included. Among 214 pairs of ORs of large and small studies, 66 pairs (30.84%) were inconsistent in the direction of ORs based on Peto OR (Kappa =0.33), and 69 pairs (32.24%) were inconsistent in the direction of ORs based on classical OR. The Peto ORs resulted in smaller P-values compared to classic ORs in a substantial (83.18%) number of cases. Conclusion There are considerable differences between large and small studies in the results of meta-analysis of rare events.