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find Author "陈蕾" 48 results
  • 中枢神经系统疾病基因治疗中的病毒载体应用

    Release date:2016-09-08 10:14 Export PDF Favorites Scan
  • 睡眠呼吸暂停致缺血性脑卒中病理机制的研究进展

    睡眠呼吸暂停综合症被定义为7 h 睡眠中呼吸暂停及低通气反复发作在30 次以上, 或呼吸紊乱指数( AHI) ≥5 次/h。由其引起的睡眠时反复发生的低氧血症和高碳酸血症, 不仅可导致呼吸系统的病理生理变化, 同时可引起循环系统、血液系统、内分泌系统及神经系统等一系列连锁反应, 亦可引起包括缺血性脑卒中在内的一些危及生命的危重症[ 1 ] 。缺血性脑卒中是指突然发生的脑组织局部供血动脉血流灌注减少或血流完全中断, 停止供血、供氧、供糖等, 使该局部脑组织崩解破坏。Basetti 等[ 2] 研究发现, 在脑卒中患者中, 阻塞性睡眠呼吸暂停综合征 ( OSAS) 的患病率为44% ~72% , 而在正常人群中仅为4% 。而Fischer 等[ 3 ] 发现OSAS 患者发生脑梗死的概率是无OSAS 的31 倍。一项大型的前瞻性流行病学研究显示, 在校正其他危险因素( 包括高血压) 后, OSAS患者发生脑卒中或出现死亡的危险度为1. 97( 95% CI 1. 12 ~3. 48, P = 0. 02) [ 4 ] 。Arzt 等[ 5] 对1475 例研究对象的研究结果显示, 在校正年龄、性别、体重指数( BMI) 、吸烟及饮酒史等因素的影响后, 有重度OSAS者( AHI gt; 20 次/h) 较无OSAS 者( AHI lt; 5 次/h) 脑卒中发生有明显差异( OR 4. 33; 95% CI 1. 32 ~14. 24, P = 0. 02) , 从而证实了睡眠呼吸暂停综合征为脑卒中发生的独立危险因素。但其发生发展的具体机制尚不完全清楚。从目前国内外的多项研究推测, 可能与下列因素有关。

    Release date:2016-09-13 03:51 Export PDF Favorites Scan
  • A review of clinical trial registration and its application in neurology

    Clinical trial, an important research method, plays a crucial role in the development of medicine. It provides important decision support for medical workers. Medical research proposal should be posted at clinical trial registries. Researchers should update original data and research results, which contributes to data sharing. Clinical trial registration can avoid repetitive research and make clinical trials more transparent and standardized. This paper briefly introduces the clinical trial registration, including the definition, the significance, the history, the scope of registration, the organization of registration, and some common problems in the process of registration. Taking the application of clinical trial registration in the field of neurological research as an example, the article describes the current application status of clinical trial registration and explores it’s value and deficiency in specific clinical research, to provoke the awareness on trial registration, which can help to improve the quality of clinical trials.

    Release date:2018-06-26 08:57 Export PDF Favorites Scan
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  • 中心性渗出性脉络膜视网膜病变中心外视力患者光相干断层扫描检查

    Release date:2016-09-02 05:48 Export PDF Favorites Scan
  • Training of medicine-engineering postgraduates: integrated thinking of China and west countries

    In the new era of development, countries in the world have realized the importance of cultivating interdisciplinary and innovative talents, and China is also paying more and more attention to the cultivation of medicine-engineering talents. Compared with the cultivation of single discipline postgraduates, the cultivation of medicine-engineering postgraduates involves effective integration of multiple disciplines, and its cultivation difficulty is greater. At present, China is still in the exploration stage of the medicine-engineering postgraduates training model. Therefore, this article intends to summarize the relatively mature and advanced medicine-engineering postgraduates training models at home and abroad, and extract experiences that are in line with China’s actual development, providing some suggestions for the establishment of postgraduates training systems of medicine-engineering interdisciplinary in China.

    Release date:2024-02-29 12:02 Export PDF Favorites Scan
  • 2023 美国癫痫学会年会荟萃报道(五)

    美国癫痫学会(American Epilepsy Society,AES)年会是每年一度国际癫痫学界及工业界最受关注的会议。本年度的AES年会自2023年12月1日在奥兰多召开,为期5天,讨论了目前最受关注的癫痫学术领域及重点突破。本系列文章将分为五期,分别对大会每日的精彩内容进行荟萃报道:本文对大会第五日学术议程的内容进行了整理汇总,重点内容包括新生儿癫痫的基因检测、自动化癫痫检测、脑电监测、精准医学、最新循证医学证据等。

    Release date:2024-03-07 01:49 Export PDF Favorites Scan
  • 2023美国癫痫学会年会荟萃报道(三)

    美国癫痫学会(American Epilepsy Society,AES)年会是每年一度国际癫痫学界及工业界最受关注的会议。本年度的AES年会自2023年12月1日在奥兰多召开,为期5天,讨论了目前最受关注的癫痫学术领域及重点突破。本系列文章将分为五期,分别对大会每日的精彩内容进行荟萃报道:本文对大会第三日学术议程的内容进行了整理汇总,重点内容包括癫痫诊断及治疗的合理时机和最佳方案甄选,以及发育性癫痫性脑病、癫痫持续状态、基因性癫痫、术前评估、神经影像等热点话题。

    Release date:2024-03-07 01:49 Export PDF Favorites Scan
  • 糖尿病大鼠模型视网膜中血管内皮生长因子和色素上皮衍生因子mRNA的动态变化及意义

    Release date:2016-09-02 05:51 Export PDF Favorites Scan
  • 甲状腺功能减退伴进行性延髓麻痹

    Release date:2016-08-26 03:57 Export PDF Favorites Scan
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