To investigate the change of the portal venous pressure (PVP), conjugated glycocholic acid (CGA) and pancreatic glucagon (PG) concentration in rats peripheral and portal venous blood in the course of experimental liver cirrhosis induced with carbon tetrachloride and to investigate the mentioned changes after portalazygous devascularization. The authors found that in the early stage of cirrhosis the PVP and the concentration of CGA and PG in peripheral venous blood were increased markedly, CGA in portal vein was decreased and PG in portal vein was increased in early stage of liver cirrhosis.With the extent of liver cirrhosis the indexes above changed more markedly. After portalazygous devascularization the concentration of CGA in peripheral vein in the cirrhotic rats was increased but PVP, the concentration of CGA in portal vein and PG in peripheral and portal vein did not change.There was no change in nornal rats. The results suggest that the variation in CGA in peripheral vein can accurately reflect the degree of damage to liver cells, thus making the diagnosis of liver cirrhosis earlier and judging the degree and prognosis of liver cirrhosis.The concentration of PG in portal venous and peripheral vein relate to PVP in liver cirrhosis.Portalazygous devascularization can maintain PVP and PG in portal vein and do not affect liver function of the control rats but it can damage liver cell in cirrhotic rats.
门脉高压性胃病是肝硬变门脉高压症患者的主要并发症之一，病变几乎累及全部消化道，现就门脉高压性胃病的临床表现、病理特点、发病机理、诊断与治疗讨论如下……
目的:探讨肝硬化门脉高压性结肠病与肝功能分级、食管静脉曲张、下消化道出血的关系以及内镜下特征,为诊治该类疾病提供一些依据。方法:回顾性分析48例肝硬化门脉高压患者临床表现及内镜特征,并对其并发的肝硬化门脉高压性结肠病进行分析。结果:48例肝硬化门脉高压患者中, 肝硬化门脉高压性结肠病发生率542%。 随着肝硬化门脉高压病程的延长,其门脉高压性结肠病的发生率明显增加,下消化道出血的机会也明显增加;而门脉高压性结肠病的发生与肝功能分级无关。结论:肝硬化门脉高压患者常出现门脉高压性结肠病。门脉高压性结肠病是肝硬化门脉高压患者下消化道出血的主要原因,但不是唯一原因。
Objective To study the diagnosis and treatment of portal hypertension in secondary biliary cirrhosis(PHSBC). MethodsTwenty-five cases of PHSBC within recent 16 years in our hospital were analyzed. Their clinical, pathological and follow-up data were reviewed retrospectively. They were divided into 4 groups according to their primary diseases:13 patients with hepatolithiasis, 6 with postoperative stricture of biliary duct, 4 with malignancy of biliary duct and 2 with others.Results All patients were diagnosed clinically, and 4 were further pathologically confirmed. Eight cases were treated conservatively, while the remaining 17 underwent operations according to their primary diseases, and one combined with splenectomy and esophagogastric devascularization. The rate of discharge with improvement by surgical and non-surgical treatment was 64.7% and 37.5%, and hospital mortality was 17.6% and 12.5% respectively. Conclusion The diagnosis of PHSBC mainly depends on its characteristic clinical manifestations. The early surgical resolution of bile duct obstruction is the key to good prognosis. If complicated with rupture and hemorrhage of oesophagofundal varices, the surgical procedure should be considered carefully.
In the treatment of portal hypertension, association of both hassab operation and splenorenal shunt was performed selectively on six cases by authors from 1987 to 1994, and better results were obtatined in five patients. In this article, the experience and operative Techniques are introduced in detail, and he advantages of this procedure are evaluated.
【摘要】目的 探讨肝硬变门静脉高压症患者术前肝脏备功能的评估方法。方法 用Logistic多元回归法分析了78例门静脉高压症行断流术患者术后出现肝功能不全的相关因素，从中筛选与肝功不全关系最密切的危险因子。结果 术后发生肝功不全影响最大的因素依次为： 肝性脑病（EN）、血浆吲哚氰绿潴留试验（ICGR15 min）及门静脉充血指数（PCI）等，而术前的血清总胆红素（TBIL）、白蛋白（A）、凝血酶原时间（PT）、门静脉内径（dp）、门静脉流速（Vp）及门静脉流量（Qp）等因素，在多元回归中所占比例不大。结论 综合分析术前患者临床指标和肝功能实验室检查有助于评价肝硬变患者肝储备功能，预测手术风险及术后转归。
目的 探讨胰源性门脉高压症的临床特点和诊治方法。 方法 回顾性分析聊城市第二人民医院1995年5月至2005年10月收治的23例胰源性门脉高压症病例资料。结果 全部病例均在术前确诊，并接受手术治疗。行胰头十二指肠切除术6例、胰腺囊肿内引流术1例、胰体尾切除术4例、脾切除术6例、介入行选择性脾动脉插管栓塞术3例及曲张静脉内镜下套扎硬化术3例。术后死亡2例,发生胰瘘1例。生存者临床症状均明显改善。结论 胰源性门脉高压症诊断不难，治疗应兼顾原发病及门脉高压两方面，才能取得较好疗效。
This study was to build a canine portal hypertension model by intra-portal administration of high polymer material polyurethane and organic solvent tetrahydrofuran mixed solutions in order to evaluate the effectiveness of the model. Twelve local crossbreed dogs were selected randomly, with intra-portal administration of 8% (weight/volume) polyurethane-tetrahydrofuran solutions through an incision in the upper abdomen to build the portal hypertension model. We measured the portal vein pressure before modeling, during modeling, and four-, eight-, and twelve-weeks after modeling, respectively. Then we evaluated the effectiveness of the model comparing values of data with those data obtained before modeling started, which were regarded as the normal values. The results showed that the portal vein pressure rose by 2.5 times after the solution administrated instantly as much as that before modeling, and maintained at 1.5 times after 4 weeks. This method presents an easy operation, low animal mortality and reliable model of portal hypertension. Its less abdominal adhesions and its ability in keeping normal anatomic structure specially make it suit for surgical research of portal hypertension.