ObjectiveTo systematically review the effectiveness of breastfeeding duration and intensity in reducing the risk of overweight or obesity among offspring exposed to intrauterine hyperglycemia. MethodsThe PubMed, EMbase, Web of Science, CBM, WanFang Data, CNKI and VIP databases were electronically searched to collect observational studies on the associations of breastfeeding with the risk of overweight or obesity among offspring exposed to intrauterine hyperglycemia from inception to September 25th, 2021. Two reviewers independently screened the literature, extracted data and assessed the risk of bias of the included studies. Stata 16.0 software was used for the meta-analysis. ResultsA total of 12 657 participants from 13 observational studies were included. The results of meta-analysis showed that breastfeeding could reduce the risk of overweight or obesity among offspring exposed to intrauterine hyperglycemia (OR=0.67, 95%CI 0.53 to 0.84, P=0.001). Subgroup analysis revealed a protective effect of breastfeeding for both 1-6 months (OR=0.53, 95%CI 0.37 to 0.75, P<0.001) and ≥6 months (OR=0.56, 95%CI 0.46 to 0.69, P<0.001); however, breastfeeding shorter than one month was suggested to increase the risk of overweight or obesity (OR=2.15, 95%CI 1.41 to 3.27, P<0.001). ConclusionAvailable evidence suggests that breastfeeding for more than one month is effective in reducing the risk of overweight or obesity in offspring exposed to intrauterine hyperglycemia, and women with hyperglycemia should be encouraged to breastfeed their offspring for at least 1 month to achieve the effect. Due to the limited quantity and quality of the included studies, more high-quality studies are needed to verify the above conclusion.
The necessity and methods of systematic review or Meta-analysis of observational studies were introduced. The difference between the systematic review or Meta-analysis of observational studies and randomized controlled trials was also described.
【摘要】 目的 探讨儿童弱视治疗效果与疗程的关系。 方法 对2002年5月-2007年5月收治的25例弱视患儿进行戴镜、遮盖、红光闪烁及精细作业训练。3个月复查一次，12个月重新验光，随访12~60个月。 结果 25例弱视患儿经12~60个月随访，25例患儿均治愈，治愈疗程最少3个月，最长达60个月，平均24个月。 结论 儿童弱视只要早期发现，在12岁之前进行干预，早期治疗均可获得治愈。【Abstract】 Objective To discuss the relationship between the effect and duration of the treatment for children amblyopia. Methods Patients diagnosed as amblyopia were administered wearing glasses, occlusion, flashing red, and fine training from May 2002 to May 2007. Reexamination was done 3 months later after the treatment, and the refraction examination was done after 12 months. The follow-up time was from 12 to 60 months. Results The results showed that all of the 25 amblyopic children were cured. The treatment duration was from three months to 50 months with an average of 24 months. Conclusion As long as the amblyopia is detected at the early stage and treated before age 12, all the children can be cured.
目的：观察古方止嗽散加味治疗喉源性咳嗽的疗效。方法：采用加味止嗽散治疗喉源性咳嗽116例，并设西药对照组113例。结果：治疗组有效率87.3%，对照组有效率68.2%，两组比较有显著差异(Plt;0.01)。治疗组不良反应例数为零；对照组不良反应例数约占10.2%。结论：加味止嗽散具有疏风宣肺、清热解毒、利咽祛痰、益气养阴、扶正祛邪、抗病毒、抗菌、抗炎和增强免疫功能等功效，为治疗喉源性咳嗽的有效方药。
【摘要】 目的 探讨口服百草枯中毒患者口腔护理的方法及早期护理的临床意义。 方法 2009年1月-2010年3月，采用半随机方法将62例白草枯中毒患者按中毒时间的长短分A组（中毒时间lt;3 d，n=32）、B组（中毒时间gt;3 d，n=3），比较两组患者口腔溃疡的治愈率、并发症发生状况，分析早期口腔护理的必要性。 结果 A组患者百草枯所致的口腔黏膜损害明显减轻，并发症发生率降低，为改善预后提供了条件，显示了早期加强口腔护理的成效。 结论 重视百草枯早期口腔护理，能够减轻口腔糜烂溃疡痛苦，减少并发症，提高患者生活质量。【Abstract】 Objective To investigate the clinical significance of early oral care for paraquat-poisoned patients. Methods A quasi-randomized controlled trial was used. A total of 62 paraquat-poisoned patients (from January 2009 to March 2010) were divided into experimental group and control group in order to compare the healing rate of oral ulcer, complications and the necessity of early oral care between the two groups. Results The oral mucosa lesions in experimental group obviously alleviated and the complications decreased. The effective early oral care provided the very favorable conditions for better prognosis. Conclusion The early oral care for paraquat-poisoned patients could relieve the pain of oral ulcer, reduce the complications and improve patient′s life quality.
目的 总结分析急诊观察室患者流行病学特点及临床疗效，为临床急诊治疗提供指导。 方法 以2007年1月－2010年12月收治的247 312例急诊观察室患者为研究对象，按年龄、性别、地域分布、疾病种类、发病时间、好转率、收入院百分率、死亡率等因素进行流行病学分析。 结果 各年度患者人数呈增加趋势，2010年减缓；城镇患者占91.5%；20～40岁患者占45.9%，40～60岁患者占27.2%，＞60岁占21.3%；疾病种类分布中呼吸系统占42.4%，心血管疾病患者数量呈升高趋势，以老年人为主，中毒患者呈下降趋势。全年6、7、8月份因发热、上呼吸道感染患者较多，总数增加明显，其次11、12、1月份因慢性支气管炎急发患者较多，总数也有升高趋势；白天工作时间患者数量占66.2%；平均每天就诊人次为169.4人次，节假双休日平均每天就诊人次为191.1人次（P＜0.01）；各年度好转率呈升高趋势，收入院百分率无显著变化，死亡率无显著区别。 结论 近年急诊观察室患者以呼吸系统疾病为主，好转率呈升高趋势，但心血管疾病数量呈升高且有年轻化趋势，值得重视。