ObjectiveTo summarize the research progress on the pathogenesis of ischemic bile duct injury after transcatheter arterial chemoembolization (TACE).MethodThe recent studies on the incidence, pathological features and related mechanisms of ischemic bile duct injury and ischemic bile duct injury after TACE were reviewed.ResultsThe incidence of ischemic bile duct injury after liver TACE fluctuated greatly and was related to different chemoembolization methods. At present, the causes of ischemic bile duct injury were attributed to the bile duct ischemia caused by embolization and the toxic effects of chemotherapeutic drugs. The destruction of protective mechanism of bile duct epithelium and the expression of transforming growth factor-β might play an important role in ischemic bile duct injury.ConclusionsAfter liver TACE, in addition to the direct injury of bile duct caused by the toxic effects of ischemia and chemotherapy drugs, the damage of bile duct epithelial protection mechanism caused by ischemia and chemotherapy drugs makes the toxic effects of bile acids play a very important role in the ischemic bile duct injury. However, there is still no direct evidence of bile duct epithelial protection mechanism in ischemic bile duct injury after liver TACE. Further clarifying the role of bile duct epithelial protection mechanism in ischemic bile duct injury after liver TACE will be helpful to explore its prevention and treatment measures, and provide new insights for the further studies in future.
ObjectiveTo explore technical essentials and safety of laparoscopic cholecystectomy (LC) guided by gallbladder ampulla localization on an imaginary clock for cholecystitis.MethodsA retrospective study of 8 707 continuous patients with mild cholecystitis who underwent LC from July 1998 to February 2018 at a single institution was conducted. Among them, 3 168 patients were treated by the traditional LC from July 1998 to February 2007 (a traditional LC group), 5 539 patients were treated by the LC with the guidance of the gallbladder ampulla localization on an imaginary clock from March 2007 to February 2018 (a gallbladder ampulla localization group). The conversion to open surgery, bile duct injury, return to the operating room due to postoperative massive abdominal bleeding, bile leakage without bile duct injury, operative time, intraoperative blood loss, and postoperative hospital stays were compared between the traditional LC group and the gallbladder ampulla localization group.ResultsThere were no significant differences in the gender, age, course of disease, and type of cholecystitis between these two groups (P>0.050). The rates of conversion to open surgery, bile duct injury, return to the operating room due to postoperative massive abdominal bleeding, bile leakage without bile duct injury and the operative time, intraoperative blood loss and postoperative hospital stays in the traditional LC group were 3.00% (95/3 168), 0.13% (4/3 168), 0.09% (3/3 168), 0.03% (1/3 168), (43.6±12.6) min, (18.7±3.3) mL, (3.6±2.7) d, respectively, which in the gallbladder ampulla localization group were 0 (0/5 539), 0 (0/5 539), 0 (0/5 539), 0 (0/5 539), (32.2±10.5) min, (12.4±3.5) mL, (3.5±2.8) d, respectively. The differences of conversion to open surgery, bile duct injury, return to the operating room due to postoperative massive abdominal bleeding rates, and the operative time and intraoperative blood loss were statistically significant between these two groups (P<0.050). The differences of the bile leakage without bile duct injury rate and postoperative hospital stays were not statistically significant between the two groups (P>0.050).ConclusionThis study shows that gallbladder ampulla localization on an imaginary clock is useful for ductal identification so as to reduce bile duct injury and improve safety of LC in case of no conversion to open surgery.
目的 总结术中胆道造影的应用体会。方法 回顾性分析甘肃省中医院2000年5月至2007年12月期间进行术中胆道造影151例患者的临床资料。结果 所有患者术中胆道造影均顺利完成。经胆囊管造影成功者75例，其中有65例将软管直接置入胆囊管中造影，有10例经钢针穿刺胆囊管造影； 有4例直接穿刺胆总管造影； 经T管造影者72例，均直接从T管内注入造影剂。本组151例手术患者均1次完成手术，没有残余结石或术后胆管损伤的发生。结论 术中胆道造影可避免残余结石及胆管损伤的发生。
目的 总结腹腔镜胆囊切除术（LC）胆管损伤的特点和处理经验，以提高治愈率。方法 回顾性分析81例LC术中胆管损伤的临床资料。结果 49例肝总管刺破伤，及时于腹腔镜下缝合8例，中转开腹修补33例，术后发现再开腹修补8例； 12例胆总管横断伤，术中发现10例中转开腹行胆总管端端吻合术、T管支撑引流，术后发现2例先行腹腔引流，3个月后再行胆肠吻合； 8例胆总管部分夹闭者，行剖腹取钛夹、T管支撑胆管引流半年； 10例肝总管及胆总管缺损和2例肝总管缺损伴左、右肝管部分夹闭者，均先行引流，3个月后再行肝门胆管空肠吻合术。全组病例经上述治疗后均痊愈出院。结论 不同类型的胆管损伤应采用不同的方式在不同的时间进行相应处理可获良好疗效。
目的 探讨腹腔镜胆囊切除术（LC）并发症的诊断及治疗。方法 回顾性分析我院1994年3月至2009年3月行LC的1 634例患者的临床资料，对术中及术后并发症的发生原因及诊断和治疗进行分析。结果 本组发生并发症22例，发生率为1.35%。术中胆管损伤4例（0.24%），胃肠道损伤2例（0.12%），均行中转开腹手术。术后漏胆8例（0.49%），均行开腹手术; 腹腔出血4例（0.24%），行开腹手术2例，腹腔镜探查止血2例; 严重皮下气肿1例（0.06%），反复行抽吸治疗; 胆总管残余结石3例（0.18%），行开腹手术2例，消炎利胆药物治疗1例。全组病例经上述治疗后均治愈出院。结论 胆管损伤、漏胆、胆总管残余结石、腹腔出血以及胃肠道损伤是LC手术的主要并发症，及时诊断和治疗并发症是提高治愈率的关键。
To analyse the causes of biliary injuries and summuarize the experience of prevention of biliary injury during laparoscopic cholecystectomy (LC). Twenty-three patients with biliary duct injury were diagnosed and treated at our center between September 1992 and August 1998. The main causes were either misidentification of the bile duct or aberrant right duct as the cystic or injudicious use of thermal energy (cautery) to dissect, control bleeding, or divide tissue. Conclusion: The causes of biliary duct injury are complex. Training and experience of sugeon, the meticulous dissection of the calot′s triangle and preoperative or operative cholangiography are three key factors in prevention of biliary duct injury during LC.
目的 探讨腹腔镜胆囊切除术（LC） 中采用提胆囊壶腹、看Rouviere沟、胆囊后三角入路法切除胆囊，对成功完成LC和预防胆管、血管损伤的临床意义。方法 2009年7月至2011年12月期间应用提胆囊壶腹、看Rouviere沟、从胆囊后三角入路法（研究组） 切除胆囊112例，同期常规方法（对照组） 行LC 55例，比较2组的临床疗效。结果 2组一般临床资料比较差异无统计学意义（P＞0.05），具有可比性。研究组112例成功完成了LC，无中转开腹及并发症发生。对照组55例LC发生并发症3例，其中2例胆管损伤及1例左肝动脉损伤。研究组的并发症发生率明显低于对照组〔0 （0/112）比5.45% （3/55），P＜0.05〕，研究组和对照组间术中出血量、手术时间、住院时间及中转开腹率差异均无统计学意义 〔术中出血量： （8.95±3.95） mL比（8.09±3.91） mL，P=0.189；手术时间：（84.72±37.15） min比（77.05±37.22） min，P=0.212；住院时间：（6.40±2.39） d比（7.02±3.41） d，P=0.178〕。结论 在LC中，采用提胆囊壶腹、看Rouviere沟、从胆囊后三角入路法，相对容易精准解剖壶腹部与胆囊管移行区，完整显露胆囊壶腹部、胆囊管、胆总管及胆囊动脉，既是成功完成LC的保证，又可有效避免术中胆管和血管的损伤。
目的 探讨腹腔镜胆囊切除术中避免胆管损伤新方法的安全性。方法 回顾性分析2008年1月至2012年1月期间笔者所在医院采用Rouviere沟引导定位的方法进行腹腔镜胆囊切除术患者的临床资料，并在手术时间和术后并发症发生率方面与同期传统手术组病例相比较。结果 与传统手术组比较，Rouviere沟引导组患者的手术时间缩短，术后并发症发生率及中转开腹率降低，其差异均有统计学意义（P＜0.05）。结论 采用Rouviere沟引导定位法进行腹腔镜胆囊切除术能有效缩短手术时间，减少胆管损伤的发生概率，值得在临床推广应用。
目的 探讨围手术期处理措施在胆管损伤（BDI）治疗中的作用。方法 分析我院1990年7月至2008年7月期间46例BDI患者的临床资料。结果 46例BDI患者术中发现32例，术后发现13例，1例外伤所致。2例BDI患者行二期胆管修复术后，死于漏胆引起的弥漫性腹膜炎及全身衰竭，1例十二指肠降部憩室手术胆胰管损伤死于并发症，2例胆肠吻合因反复胆管炎死于全身衰竭。结论 除手术措施外，围手术期处理措施对BDI预后有重要影响。应及时发现并处理BDI，术中胆管造影对诊断和治疗有指导意义，术后发现BDI并严重腹腔感染者，围手术期应选择恰当的非手术处理措施有效控制病情后决定手术时机。