Systemic lupus erythematosus is an autoimmune disease involving multiple organs of the body. Lupus nephritis is one of the most serious organ manifestations of systemic lupus erythematosus. Vimentin, a member of the intermediate filament protein family, is involved in the pathogenesis of many autoimmune diseases, including lupus nephritis. More and more studies have shown that vimentin plays an important role in the pathogenesis of lupus nephritis, and has an important influence on the disease development, treatment and prognosis of lupus nephritis. This review focuses on the structure, function and post-translational modification of vimentin, the relationship between vimentin and the pathogenesis of lupus nephritis, and the significance of vimentin expression levels in renal tissues, serum and urine, in order to provide theoretical basis for future mechanism research and clinical application.
Objective To assess the effectiveness and safety of mycophenolate mofetil (MMF) in the treatment of proliferative lupus nephritis. Methods We searched CBM (November 1979 to February 2006), Chinese Cochrane Centre Database (2005), The Cochrane Library (Issue 4, 2005), MEDLINE (November 1966 to February 2006) and EMBASE (1975 to February 2006) for randomize controlled trials. Data were extracted and analyzed using The Cochrane Collaboration’s RevMan 4.2.7. Results Nine randomize controlled trials involving 512 patients met the inclusion criteria. The meta-analysis showed that the total clinical effective rate and complete remission rate were not significantly higher for MMF than for cyclophosphamide, azathioprine, or both. Renal survival rate and relapse rate of MMF were not significantly different from those for cyclophosphamide, azathioprine, or both. Patient survival rate and safety of MMF were significantly improved compared with cyclophosphamide, azathioprine, or both. Conclusion More large-scale multi-center randomized trials are needed to investigate the role of MMF in the treatment of proliferative lupus nephritis.
摘要:目的: 观察急性链球菌感染后肾炎(APSGN)患儿血压变化规律。 方法 :观察15例重型APSGN(重型组)和20例普通型APSGN(普通组)患儿病程中各时期血压及尿量变化,并进行免疫和生化指标对比。 结果 :APSGN患儿高血压总共26例(7429%),其中重症组高血压14例(933%),普通组高血压12例(60%),高血压发生率重症组高于普通组〖WTBX〗P lt;005。重症APSGN患儿入院时舒张压、少尿期收缩压舒张压、多尿期舒张压与普通组比较均有显著性差异,〖WTBX〗P lt;005;而且重症APSGN与普通组在少尿期持续时间、尿量、多尿期持续时间、尿量的指标比较也均有显著性差异,〖WTBX〗P lt;005。重症APSGN患儿血IgG、BUN、Cr明显高于普通APSGN,Plt;005。 结论 :高血压是APSGN主要临床表现之一,血压增高多发生于少尿期,但重症APSGN患儿于多尿期出现血压增高的第二次高峰,临床上应注意监测,及时治疗。Abstract: Objective: To observe the law of the changes of children’s blood pressure after the infection of steptococcus with acute nephritis(APSGN).〖WTHZ〗Methods :Watching 15 cases of serious APSGN and 20 cases of ordinary APSGN for their changes in blood pressure and their urine amounts in various periods; contrasting their indexes in immunity and biochemistry.〖WTHZ〗Results :Among 26cases(7429%)of patients’high blood pressure with APSGN,of which 14cases (933%)are serious ones and 12cases (60%)are ordinary ones,the occurrence rate of the serious group is higher than that of the ordinary group, Plt;005At the initial stage, either the diastolic presssure or the diastolic pressure and the systolic pressure of the serious group with a small amount of unine, the diastolic pressure with a large amount of urine are evidently different from those of the ordinary group, Plt;005Furthermore,there are evident differences in the durations and amounts of urine with either a small or a large amount of urine, Plt;005The IgG,BUN and Cr of the serious group are evidently higher than those of the ordinary group,Plt;005 Conclusion :High blood pressure is one of the main clinical manifestations of APSGN.The increase of blood pressure mostly occurs during the period of a small amount of urine, but a second summit of high blood pressure with APSGN mostly appears in the period of a large amount of urine.It must be closely observed and therefore given the timely treatment.
目的:研究多层螺旋CT(MDCT)增强扫描对慢性肾盂肾炎的诊断价值。方法:病例组:2008年3月至2009年3月经我院诊治的慢性肾盂肾炎患者30例,均行MDCT增强扫描及静脉肾盂造影(IVP)检查,两者间隔时间不超过1周;对照组:同期无肾脏疾患,无尿路感染史,因其他原因来做腹部CT增强扫描的患者25例。由两名不同年资的腹部影像医师对拟定的征象进行观察、评价。结果:两医师对本组病例的诊断一致性极佳K=0.812,Plt;0.05)。病例组30例,双肾病变14例,单肾病变16例。单肾病变中,左肾12例,右肾4例。MDCT增强扫描显示肾盏轻度变形2例(6.7%),肾盏裸露18例(60.0%),实质凹陷征23例(76.7%),肾盂轻度扩张积水21例(70.0%),肾盂壁增厚、强化21例(70.0%),肾功能减退15例(50.0%)。5例(16.7%)仅表现为肾盂壁增厚、强化。MDCT增强扫描与IVP对肾实质凹陷征,肾盂壁增厚、强化及肾盏轻度变形的显示率有统计学差异(Plt;0.05)。结论:MDCT增强扫描能清晰地显示慢性肾盂肾炎的病理变化。与IVP比较,它能提供更多肾实质的信息,对判定慢性肾盂肾炎所造成的肾脏损害程度及疾病预后具有很高的价值,不过对肾盏轻度变形的显示有赖于延迟扫描。
purpose To study the visual electrophysiological changes in patients with chronic glomerulonephritis. Methods The visual evoked potentials(VEP) and electroretinogram(ERG) of 26 subjects with chronic glomerulonephritis in 51 eyes were recorded. Results Ours studies showed the patients with chronic glomerulonephritis had pathologic visual electrophysiologic abnormalities.The N 75 peak latency,b wave peak latency O 1 peak latency and total amplitude of OPs in chronic glomerulonephritis patients without fundus sign showed remarkable difference. Conclusion These changes suggested visual electrophysiological examination may be valuable in early diagnosis of retinal disfunction in patients with chronic glomerulonephritis. (Chin J Ocul Fundus Dis,1998,14:162-164)