Purpose To evaluate shortterm visual acuity effects of a single photodynamic therapy(PDT) treatment with Visudyne (CIBA Vision Corp, Duluth, Ga) for choroidal neovascularization (CNV) in age-related macular degeneration (AMD). Methods Definitely diagnostic AMD patients with classic CNV were treated with PDT (5 cases, 7 eyes). The data of visual acuity testing, ophthalmic examination, color photographs, optic coherence tomography, fluorescein angiograms and indocyanine green angiogram before photodynamic therapy and 1 week ,1 month after it were used to evaluate the effects of a single treatment of PDT with Visudyne. Results The visual acuity of all the treated eyes at the follow-up examination at 1 month after PDT were not reduced. Distinct reduction of fluorescein leakage from CNV was noted in all patients by 1 week after PDT. Fluorescein leakage from a portion of the CNV reappeared by 1 month after treatment in 2 eyes. Conclusion PDT with Visudyne achieved short-term cessation of fluorescein leakage from CNV without loss of vision or growth of classic CNV in some patwo ients with AMD. (Chin J Ocul Fundus Dis,2000,16:213-216)
Objective To explore the early effect following resection of ilealcecum and right hemicolon. MethodsTwenty piglets were randomly divided into 2 groups, 10 in control group and experimental group respectively. The ilealcecum and right hemicolon for 50 cm each were resected in the experimental group. The two groups were fed the same food before and after the operation. Some indexes of two groups were monitored. Results①In the two groups, the body length change wasn’t significant (Pgt;0.05); but the body weight had descended markly in experimental group, compared with control group, since 3 weeks after operation (Plt;0.05). ②In experimental group, the ileal bacteria were increased from 104-107/ml before operation to 109-1011/ml at 6 weeks after operation (Plt;0.05). ③The enterohepatic circulation of biliac acid was affected during the early phase after resection. ④In experimental group, the stool became diluted within 6 weeks after operation. ⑤In the two groups, the Vitamin B12 was waved slightly within 6 weeks after operation (Pgt;0.05). The megaloblastic anemia was not appeared. ⑥The function of liver and the absorption of Na+, Cl-,K+ did not change significantly (Pgt;0.05). Conclusion The ileocecum and right hemicolon are very important for digestion and absorption, it should be retained or the ileocecal valve should be reconstructed if possible.
Objective To study the role of hydrogen sulfide （H2S） in prophase of acute peritoneal cavity infection. Methods NaHS was taken as a donor of H2S. Seventy-two Sprague-Dawley rats were divided into 4 groups randomly：control group， cecal ligation and puncture （CLP） and treated with natural saline group，CLP and treated with NAHS group， and CLP and treated with DL-propargylglycine （PAG， an inhibitor of H2S formation） group. Selected 6 rats at 2h， 6h， and 12h after treatment in each group. The contents of TNF-αand H2S in serum and the content of MPO in intestinal tissue were measured， respectively. The histopathological change of ileum tissues were observed at 6 h after treatment in each group. Results The H2S could alleviate CLP-induced inflammation obviously， decrease the content of TNF-α in serum when inflammation，and attenuate the infiltration of neutrophilic granulocyte in small intestine. Conclusion The H2S has anti-inflammation effect in prophase of acute peritoneal cavity infection.
目的:评价硫普罗宁钠治疗急慢性肝炎的有效性与安全性。方法:采用随机、双盲模拟、阳性药平行对照试验方法。硫普罗宁钠200mg静滴Qd,对照组用凯西莱(硫普罗宁)200mg静滴Qd。疗程均为4周,停药后随访4周。结果:共治疗急性肝炎患者7例,慢性肝炎患者18例。急性肝炎组:试验组与对照组4周末ALT下降率分别为69.14±39.23％及68.23±45.12％,试验组显效率33.33％,总有效率100％,对照组显效率25％,总有效率100%,两组疗效比较无显著性差异(Pgt;0.05)。慢性肝炎组:试验组与对照组4周末ALT下降率分别为44.34±53.1％及35.01±74.67％,试验组显效率22.2％,总有效率77.8％,对照组显效率11.11％,总有效率66.67％,两组疗效比较无显著性差异(Pgt;0.05)。急性肝炎组未见不良反应,慢性肝炎组中试验组及对照组不良反应发生率均为5.00%。结论: 硫普罗宁钠具有保肝降酶作用,临床上用于治疗急慢性肝炎患者安全有效。
Objective To observe the clinical phenotype of patients with CACNA1F gene variant. MethodsA retrospective clinical study. From January 1, 2022 to October 1, 2023, 36 patients with CACNA1F gene mutation-related eye diseases diagnosed by clinical examination and genetic testing in Changsha Aier Eye Hospital and Jinan Purui Eye Hospital were included in the study. All patients underwent best-corrected visual acuity (BCVA), medical optometry, fundus color photography, optical coherence tomography, full-field electroretinography (ERG), nystagmus examination, and genetic whole-exon sequencing. BCVA was performed using log visual acuity charts and converted to (logMAR). The nystagmus examination was performed using a helmet-mounted multifunctional video eye movement recording system. The clinical phenotypic characteristics were observed. Results At total of 36 patients were male, aged was (6.69±5.26) years. There were 36 cases of myopia (38.89%, 14/36), and the spherical equivalent was (−3.01±4.84) D. There were 14 different genetic variants including 7 cases of pathogenic variants, 20 cases of suspected pathogenic variants and 9 cases of unknown pathogenic variants, respectively. logMAR BCVA was 0.67±0.27; 26 patients had optic nerve atrophy (72.22%, 26/36); 6 had optical nerve hypoplasia (16.67%, 6/36). Fundus pigment dysplasia with mild iris transillumination was found in 4 cases (11.11%, 4/36). There were 5 cases of foveal dysplasia (Thomas grade) 1 (13.89%, 5/36). In full-field ERG examination, the B-wave reduction of the maximum mixed reaction of dark adaptation showed a negative waveform, and the amplitude of the shock potential was seriously reduced. The main phenotypes were residual type (residual dark adaptation 0.01 reaction wave and bright adaptation 3.0 reaction wave, and the response decreased at 30 Hz to a double-peak wide wave), dominant type of bright adaptation decreased (all light adaptation extinguished, all dark adaptation extinguished), and total extinction type (all light adaptation extinguished). Among them, 10 cases presented with residual ERG (27.78%, 10/36), 8 cases with photopic reduced ERG (22.22%, 8/36) and 18 with extinguished ERG (50.00%, 18/36). Low amplitude and high frequency pendulum (PLAHF) nystagmus waverforms were found in 32 cases (88.89%, 32/36), head oscillation in 27 cases (75.00%, 27/36) and chin up abnormal head posture in 26 cases (72.22%, 26/36), respectively. ConclusionsCACNA1F Gene variant eye diseases had diverse clinical phenotype. Clinical phenotype of PLAHF nystagmus is closely related with CACNA1F gene variant eye disease.
Blind source separation technique based on independent component analysis (ICA) can separate blood volume pulse (BVP) from the facial video and then realize the telemetry of heart rate, blood oxygen saturation, respiratory rate and other vital signs parameters. However, the superiority of ICA in BVP extraction has not been demonstrated in the existing researches. Some researchers suggested using traditional G-channel method for BVP extraction (G-BVP) instead of ICA method (ICA-BVP). This study investigated the applicability of ICA-BVP comparatively. To solve the inherent permutation problem of ICA, a spectral kurtosis-based method was proposed for BVP identification. The experimental results based on the facial video datasets from 9 subjects shows that ICA-BVP method has apparent advantages in motion artifacts attenuation and ambient light changes elimination. The kurtosis-based method achieved a good performance in BVP identification and dynamic heart rate (HR) estimation. In practical application, the proposed ICA-BVP method could present a better stability and accuracy in vital signs parameters extraction.
Objective To assess the effect and safety of Dalitong Granule in the treatment of the Piman syndrome (functional dyspepsia). Method The double-blind, double-dummy and randomized controlled method was adopted. 120 patients were randomized to the treatment group (n=90, Dalitong Granule 6 g, tid) and the control group (n=30, treated with cisapride 5 mg, tid). The therapeutic course for both groups was 2 weeks. Results All the results were analyzed on the basis of intention-to-treat and per-protocol population. In the treatment group, the markedly effective rates were 62.37% and 64.45% respectively. The effective rates were 99.55% and 96-67% respectively. In the control group, the markedly effective rates were 58-08% and 60.00% respectively. The effective rates were 90.33% and 93.33% respectively. There was no significant difference between two groups (Pgt;0.05). For effects on Piman syndrome, in the treatment group, the markedly effective rates were 53.76% and 55.56% respectively. The effective rates were 86.02% and 88.89% respectively. In the control group, the markedly effective rates were 48.38% and 50.00% respectively. The effective rates were 80.64% and 83.33% respectively. The results showed no statistical significance difference between two groups (Pgt;0.05). For effects on gastric emptying function (PP population), in the treatment group, the markedly effective rate and effective rate were 72.42% and 79.32%. In the control group those were 64.28% and 64.28%. There was no significant difference between the two groups (Pgt;0.05). ITT and PP analysis revealed similar results. No adverse effect was found in the observation. Conclusions Dalitong granule has the same clinical effect as cisapride with no obvious toxic-adverse effects.
【摘要】 目的 探讨盐酸丁咯地尔对主观性耳鸣的治疗效果。 方法 将2006年1月-2008年1月收治的91例患者随机分为丁咯地尔组（治疗组）和维生素B1组（对照组），治疗组46例58只耳，对照组45例52只耳，分别以丁咯地尔及维生素B1治疗1个月后，对两组患者耳鸣治疗有效率进行χ2检验。 结果 治疗组有效17例，显效16例，无效12例，加重1例，有效率71.7%（33/46）；对照组有效12例，显效7例，无效25例，加重1例，有效率42.2%（19/45）。两组比较有统计学意义(Plt;0.05）。 结论 丁咯地尔对缓解耳鸣有一定作用。【Abstract】 Objective To investigate the clinical effect of buflomedil hydrochlorideis on tinnitus. Methods A randomized, doubled-blind, and controlled clinical trials was conducted from January 2006 to January 2008. Ninty-one patients were divided into two groups randomly: the treatment group and controlled group (placebo group). After being evaluated by tinnitus questionnaire, the two groups were treated with buflomedil hydrochloride and vitamine B1 respectively. One month after treatment, the efficacy of the two groups was observed. The data was analyzed by χ2 test. Results The efficacy was 71.7% in the treatment group and 42.2% in the controlled group, with a significant difference between the two groups (Plt;0.05). Conclusion Buflomedil hydrochloride is effective on tinnitus.