Post-stroke cognitive impairment (PSCI) which has been a barrier to the rehabilitation, could be prevented and treated. Early assessment of cognitive impairment, as well as diagnosis and comprehensive interventions of PSCI would improve rehabilitation of stroke patients. The rehabilitation, as an important component of the comprehensive intervention, could improve cognitive function, delay disease progression, and optimize the daily life. The widely-used rehabilitation methods include cognitive intervention, exercise training, music therapy, and neuromodulation techniques, etc. Comprehensive cognitive training covering multiple cognitive domains and multimodal intervention can significantly improve the overall cognitive function of patients. The research in the PSCI field is still in its infancy in China. Thus, It is necessary to pay more attention to the PSCI clinically, and unveil the unkown area in PSCI.
ObjectiveTo observe the effectiveness of oral glucosamine hydrochloride and cupping therapy in the treatment of knee osteoarthritis. MethodsA total of 113 patients treated from February 2013 to February 2015 were randomly divided into three groups. All the three groups of patients underwent conventional treatment. The Cupping treatment group had 39 patients; 37 patients were treated with oral glucosamine hydrochloride, and another 37 patients accepted combined treatments of cupping therapy with oral glucosamine hydrochloride. Six weeks after treatment, pain degree of the patients and Lequesne index were used to assess the clinical efficacy of the treatments. Patients who had oral glucosamine hydrochloride underwent routine examinations of blood and urine, and received liver and kidney examinations. One year later, telephone follow-up was conducted to observe long-term efficacy. ResultsSix weeks after treatment, the combined treatment group was significantly better than the other two groups in terms of pain relief degree and effective rate (P ＜ 0.05) . One year after treatment, the combined treatment group and the oral treatmentgroup had a significant advantage over the cupping treatment group (P ＜ 0.05) , while there was no significant difference between the combined treatment group and oral treatment group. ConclusionsThe combined oral glucosamine hydrochloride and cupping therapy has an obvious short-term efficacy, which quickly relieves pain and improves the activity function of the knee. Oral glucosamine hydrochloride has a very good effect in the long-term treatment of osteoarthritis.
Object ive To summar ize recent advance in the appl icat ion and research of ar t i f icial chordae tendineae. Methods The cl inical and experimental research l iterature was extensively reviewed and analyzed. Results The follow-up results showed that artificial chordae tendineae replacement was superior to other operation methods in valve repair. But, it was compl icated and difficult-to-learn. In recent years with the development of many surgical skills and new techniques, good cl inical results were achieved. Conclusion With the development of surgical equi pment, chordae material, and implanting skills, artificial chordae tendineae implanting will be easier and the scope of appl ication will be larger.
Purpose To study inhibition effects of retinal pigment epithelial (RPE) cells by hyaluronic acid-stimulating activity(HASA)． Methods The cultured human RPE cells added with a series of HASA was measured with cell counting,tetrazolium(MTT)colorimetric assay and tritium labelled thymidine deoxyribosｅ(3H-TdR)incorporation assay.Flow cytometry(FCM)analysis was used to examine RPE cells cycles. Results HASA at concentrations of 12.5～200 mu;g/ml and within 48 hours inhibited RPE cells proliferation with a dose-dependant and time dependant manners.The maximal inhibition rate of RPE cells by HASF was about 48.0%.FCM revealed that the cells in G1 phase increased 7.2% and cells in S phase decreased 9.7%,compared to controls. Conclusion HASA at a certain dose range and period can inhibit RPE cells proliferation. (Chin J Ocul Fundus Dis,1999,15:72-74)
【Abstract】Objective To introduce the progress on clinic trial of antiangiogenic breast cancer therapy. Methods The current literatures on progress on clinic trial of antiangiogenic breast cancer therapy were reviewed. ResultsPathological angiogenesis is a hallmark of cancer. Concentrated efforts in this area of research are leading to the discovery of a growing number of antiangiogenic molecules, more than 30 of which are already on clinical trial. About 10 of angiogenic inhibitors are already on clinical trial of antiangiogenic breast cancer therapy. Most of them are in clinical phase Ⅰ or Ⅱ studies and a few, however, have progressed to phase III evaluation. Some results show that angiogenic inhibitors can reduce the toxicity and be less likely to generate drug resistance than conventional cytotoxic drugs. Conclusion Pathological angiogenesis is indeed essential for breast cancer metastasis and recurrence. Antiangiogenesis can cause regression of the breast cancer and provide a optimum stragy to treat the breast cancer.
ObjectiveTo systematically review the efficacy of mobile health (mHealth) apps on weight loss.MethodsWeb of Science, PubMed, CNKI, WanFang Data and CBM databases were electronically searched to collect randomized controlled trials (RCTs) on the efficacy of mHealth APPs on weight loss from inception to October 18, 2019. Two reviewers independently screened literature, extracted data and assessed risk of bias of included studies. Meta-analysis was then performed using RevMan 5.3 software.ResultsA total of 12 RCTs involving 1 074 patients were included. The results of meta-analysis showed that the apps group was superior to the control group in body weight (MD=−1.88, 95%CI −3.23 to −0.53, P=0.006). There was a decreasing trend of body mass index (BMI) in apps group (MD=−0.55, 95%CI −1.09 to 0.00, P=0.05).ConclusionsCurrent evidence shows that mHealth app can increase the efficacy of weight loss. Due to limited quality and quantity of the included studies, more highquality studies are required to verify above conclusions.