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find Keyword "放射疗法" 20 results
  • Comparison of the Outcome of Complete Excision followed by Threedimensional Conformal Radiation Therapy and Adjuvant Chemotherapy versus Adjuvant Chemotherapy Alone in the Treatment of Patients with Stage ⅢA-N2 Non-small Cell Lung Cancer

    目的:探讨ⅢA-N2期非小细胞肺癌(NSCLC)完全切除术后三维适形放疗联合辅助化疗疗效。方法:对48例ⅢA-N2期NSCLC完全切除术后患者,术后病理为腺癌18例、鳞癌27例、腺鳞癌3例,按信封法随机分为放疗组(24例)与非放疗组(24例)。放疗组采用术后三维适形放疗,4~5个非共面野,以90%~95%等剂量曲线包绕PTV,每次2 Gy,1次/日,5次/周,共照射25次,总剂量DT 50 Gy,放疗后予TP方案化疗3~4周期;非放疗组术后予TP方案化疗3~4周期。结果:放疗组1、2、3年生存率分别为95.8%、79.2%、62.5%,非放疗组分别为91.7%、58.3%、37.5%;放疗组1、2、3年无病生存率分别75.0%、58.3%、45.8%,非放疗组分别为54.2%、41.7%、25.0%;放疗组与非放疗组3年胸腔内复发分别12.5%和37.5%;放疗组与非放疗组中位生存时间分别为28个月和18个月;放疗组白细胞减少、急性放射性肺炎、气管炎发生率分别为25.0%、8.3%、12.5%,均为Ⅰ或Ⅱ级;Ⅰ级急性放射性食管炎发生率为20.8%。结论:ⅢA-N2期非小细胞肺癌完全切除术后三维适形放疗联合辅助化疗,可以降低患者胸腔内肿瘤复发、提高术后生存率。

    Release date:2016-09-08 09:54 Export PDF Favorites Scan
  • Macular morphological changes of choroidal melanoma with optical coherence tomography after plaque radiotherapy

    Objective To observe the macular morphological changes of choroidal melanoma with coherence tomography (OCT) after plaque radiotherapy (PRT). Methods A total of 48 patients (48 eyes) with choroidal melanoma who underwent125I PRT were enrolled in this study. All the patients were examined documenting OCT to get the image of macula. The macula of all the patients was not involved. The median visual acuity was 0.4plusmn;0.2, which ranged from 0.02 to 1.0. There were 18 eyes (37.5%) with retinal detachment, 12 eyes (25.0%) with retinal pigment epithelium (RPE) changes, seven eyes (14.6%) with macular edema, epimacular membrane, detachment combined with edema, exudation and RPE changes, 11 eyes (22.9%) with normal macular structure. The median follow-up time was (10.4plusmn;5.9) months, which ranged from one to 24 months. The tumor control situation and visual acuity were observed in follow-up period. The same equipment and methods of OCT were used to return visit in follow-up period. The macular morphological changes at the final visit and its relationship with PRT and visual acuity were contrastively analyzed. Results All the patients had good control of tumor. The vision acuity improved in two eyes (4.2%), unchanged in 10 eyes (20.8%), and decreased in 36 eyes (75.0%). The differences of the visual acuity was statistically significant between before and after treatment (Z=-3.778,P<0.05). There were 13 eyes (27.1%) with retinal detachment; nine eyes (18.8%) with RPE changes; 17 eyes (35.4%) with macular edema, detachment combined with edema, exudation and RPE changes; six eyes (12.5%) with proliferation, atrophy, detachment combined with edema, exudation and epimacular membrane;three eyes (6.3%) with normal macular structure. There were 15 patients (31.3%) with two or more abnormal macular morphology after PRT. Conclusions Retinal detachment, RPE changes, macular edema and exudation are common abnormal macular morphology after PRT. The incidence rate of abnormal macular morphology is increased. There are 31.3% patients with two or more abnormal macular morphology.

    Release date:2016-09-02 05:26 Export PDF Favorites Scan
  • 碘-125粒子支架植入治疗晚期食管癌

    目的 探讨附有放射碘125(125I)粒子的机织式支架植入治疗晚期食管癌的效果, 总结临床经验,以期为晚期食管癌患者的合理治疗提供临床依据。 方法 37例晚期食管癌患者应用附有125I粒子的机织式支架植入治疗,术中、术后观察随访支架植入成功率及并发症的发生率, 比较术前与术后3个月食管病变长度和白细胞计数的变化。 结果 37例患者手术过程顺利,支架植入成功率均为100%,仅3例患者胸部有明显疼痛不适感,经对症处理后缓解;随访6个月,随访33例,失访2例,死亡1例,因年龄偏大,体质较弱死亡。术后3个月,吞咽困难缓解率为100%,治疗后较治疗前食管病变长度明显缩小(Plt;0.05),而白细胞计数的变化差异无统计学意义 (Pgt;0.05)。 结论 附有125I粒子的机织式支架能明显改善吞咽困难症状,还可对肿瘤进行组织间放疗, 明显改善患者术后的生存质量。

    Release date:2016-08-30 06:05 Export PDF Favorites Scan
  • Radiotherapy Combined with Hyperthermia for Locally-Advanced Non-Small Cell Lung Cancer: A Systematic Review

    Objective To evaluate the clinical effectiveness and safety of radiotherapy (RT) combined with hyperthermia (HT) for locally-advanced non-small cell lung cancer (NSCLC). Methods The randomized controlled trials (RCTs) on RT plus HT vs. RT alone for locally-advanced NSCLC were searched in PubMed, The Cochrane Library, EMbase, VIP, CNKI, CBM and other electronic databases from inception to November 2011. Two reviewers independently screened studies according to the inclusion and exclusion criteria, extracted data and assessed quality of the included studies independently. Then meta-analyses were performed using RevMan 5.0.2. Results A total of 9 RCTs involving 527 cases were included. The results of meta-analyses showed that compared with the RT alone group, the RT plus HT group could increase the total effective rate (OR=2.08, 95%CI 1.44 to 3.02, P=0.000 1) and the progression-free survival rate (OR=4.85, 95%CI 1.88 to 12.48, P=0.001). However, there were no significant differences between the two groups in the overall survival rate (OR=1.13, 95%CI 0.64 to 1.98, P=0.68), symptoms improve rate (OR=3.37, 95%CI 1.68 to 6.78, P=0.000 6), and other acute adverse reactions. Conclusion Current results of systematic review show that radiotherapy combined with hyperthermia can obviously increase the total effective rate and improve the progression-free survival rate for locally-advanced NSCLC, and doesn’t increase the incidence of adverse reaction. Therefore, radiotherapy combined with hyperthermia is a fairly reasonable and effective treatment method for locally-advanced NSCLC.

    Release date:2016-09-07 10:58 Export PDF Favorites Scan
  • 放射性视神经病变研究进展

      放射性视神经病变(RON)是因邻近视路的头颈部放射治疗(放疗)而引起的迟发性进行性视神经并发症。临床表现以突发的、无痛性单眼或双眼视力进行性下降为主要特征。视路接受的照射剂量及照射范围是发生RON的关键因素。增强的核磁共振成像(MRI)检查以及电生理检测具有一定的辅助诊断意义;结合其临床表现、相应辅助检查及头颈部放疗史可作出诊断。虽然高压氧治疗能在发病早期一定程度上改善RON的视力损害,但目前仍然缺乏行之有效的治疗方法。因此,在制定头颈部放疗计划时应充分考虑视神经、视交叉是否在照射范围内,并注意控制照射剂量,以防止RON的发生。

    Release date:2016-09-02 05:37 Export PDF Favorites Scan
  • Priliminary observation on choroidal melanoma treated by plaque radiotherapy

    Objective To observe the therapeutic effect of plaque radiotherapy (PRT) on choroidal melanoma. Methods PRT was performed on 21 patients (21 eyes) with chroidal melanoma who had been examined by ophthalmoscopy, fundus fluorescein angiography (FFA), indocyanine green angiography (ICGA), and B-scan echography. The visual acuity was le;0.05 in 3 eyes, 0.06-0.2 in 4 eyes, and ge;0.3 in 14 eyes before the treatment. Choroidal melanoma, round or oval brown solid hunch, was located at the area around macula in 7 eyes, around the optic disc in 7 eyes, at or near the vascular arcade in 5 cases, and at the periphery in 2 eyes. The maximum length、width and thickness of tumor was 13 mm, 11.6 mm, and 9.59 mm. The isotope we used was125I, and the quantum of designed radiation was 100-120 Gy. Fourteen patients with choroidal melanoma at the macular area or around the optic disc underwent plaque radiotherapy associated with transpupillary thermotherapy (TTT). The average follow-up duration was 12 months with the longest duration of 3 years. The basis and thickness (height) of tumors were measured by B-scan echography. The aggrandizement of the tumor would be regarded if the height increased 15% or the basis boundary aggrandized 250mm. Results The visual acuity after the treatment decreased in 9 eyes, remained unchanged in 10, and increased in 2. The dimension of tumo increased in 6 eyes, remained unchanged in 12, and decreased in 3. The complication was vitreous hemorrhage in 2 eys, vascular occlusion in 1, branch retinal venous occlusion in 1, macular pucker in 1, retinal hemorrhage in 3, partial optic atrophy in 3, neovascular glaucoma in 1, and extraction of eye in 3. Conclusion The domestic plaque design is effective on choroidal melanoma, and is of a sort on the thick tumor and the tumor located at macula or beside the optic disc. (Chin J Ocul Fundus Dis, 2006, 22: 157-160)

    Release date:2016-09-02 05:51 Export PDF Favorites Scan
  • Radiotherapy for refractory choroidal hemangioma

    ObjectiveTo observe the effectiveness of radiotherapy for refractory choroidal hemangioma. MethodsEight patients (8 eyes) with choroidal hemangioma were enrolled in this retrospective study. All the patients had received laser or photodynamic therapy before without effectiveness. The patients included 7 males and 1 females. The age was ranged from 11 to 54 years old, with an average of (27.50±15.18) years. All the patients were affected unilaterally, including 3 right eyes and 5 left eyes. There were 5 eyes with circumscribed choroidal hemangioma, 3 eyes with diffused choroidal hemangioma. All eyes had extensively exudative retinal detachment. The vision was from light sensation to 0.01. The volume of the tumors was ranged from 1.96 to 5.35 cm3, with a mean of (3.37±1.06) cm3. All the patients were treated with X rays by conventional fractional radiotherapy. Four of 8 patients were applied 24Gy totally in 8 fractions, while the other 4 patients were applied 46Gy in 23 fractions. Follow-up period ranged from 7 to 95 months, with medium of 42 months. ResultsRetinas reattached in all the eyes while exudation being absorbed. No retinal detachment happened again. To the last follow-up, the vision was from light sensation to 0.6. Visual activity improved in 6 eyes while 2 eyes improved obviously. Visual acuity was stable in remaining 2 eyes. The volume of the tumors decreased to 1.24-2.16 cm3, with a mean of (1.68±0.30) cm3. The percentage of the tumor decreased by 14.6-72.7, with an average of (44.89±21.30)%. No radiotherapy-associated complication occurred. ConclusionRadiotherapy is an efficient and safe treatment for refractory choroidal hemangioma.

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  • Treatment for radiation retinopathy of uveal melanoma undergone radiotherapy: the current situation

    Radiotherapy is the prior treatment for uveal melanoma, but a major problem confronted most of the patients is radiation retinopathy, which accompanied with severe visual loss and secondary enucleation potential. There is no optium choice and normative strategy so far, the intraocular melanoma society has focused on application of anti-vascular endothelial growth factor drugs injection and glucocorticoids. This article reviews a series of potential managements for radiation retinopathy and its further stage .

    Release date:2018-09-18 03:28 Export PDF Favorites Scan
  • Progression and challenge of therapeutic strategies in neovascular age-related macular degeneration

    Choroidal neovascularization (CNV) is the key characteristic of neovascular age-related macular degeneration (nAMD), and the effective therapy is intravitreal injection of anti-vascular endothelial growth factor (VEGF) agents based on clinical and basic research. In the meantime the challenge is how to further improve the inhibiting effect for CNV and visual function of anti-VEGF treatment on nAMD. The new strategy and drug delivery devices for anti-VEGF treatment will optimize the clinical scheme. From bench to bedside, the research on targeted treatment of angiogenesis brings the bloom of nAMD medical therapy.

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  • 放化疗与单纯放疗治疗小细胞肺癌的疗效比较

    【摘要】 目的 比较放化疗与单纯放疗治疗小细胞肺癌的疗效差异。方法 2007年1月—2008年6月收治小细胞肺癌患者48例。在患者知情同意的前提下,随机分为放化疗结合组27例和单纯化疗组21例。观察并比较两组的治疗效果。结果 放化疗结合组和单纯化疗组总有效率分别为88.9%(24/27)和66.7%(14/21),放化疗结合组高于单纯化疗组(Plt;0.05)。放化疗结合组和单纯化疗组1年生存率分别为74.1%(20/27)和57.4%(12/21),放化疗结合组高于单纯化疗组(Plt;0.05)。结论 放化疗综合治疗小细胞肺癌可改善患者临床症状和生活质量,延长生存期。

    Release date:2016-09-08 09:37 Export PDF Favorites Scan
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