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find Keyword "放射疗法" 20 results
  • 手术联合放射性125I粒子植入治疗颈部及躯干部滑膜肉瘤

    目的总结手术联合放射性125I粒子植入治疗颈部及躯干部滑膜肉瘤的疗效。 方法2010年5月-2012年5月,收治颈部及躯干部滑膜肉瘤患者4例。男3例,女1例;年龄33~68岁,平均50岁。病变位于颈后部、左颈根部、右腰背部和左肩胛下各1例。病变范围8 cm×6 cm×4 cm~12 cm×10 cm×6 cm。术中避开病变周围重要结构,尽量距病变周围2 cm以上彻底切除,病变切除区植入125I粒子并以皮瓣或肌皮瓣修复,供区植皮修复。 结果术后患者皮瓣及植皮均成活,创面均Ⅰ期愈合。4例患者均获随访,随访时间18~36个月,平均26个月。皮瓣存活良好,局部均无肿瘤复发。其中1例于术后18个月因肺转移死亡。 结论手术联合放射性125I粒子植入治疗颈部及躯干部滑膜肉瘤安全易行,可有效控制肿瘤局部复发。

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  • Priliminary observation on choroidal melanoma treated by plaque radiotherapy

    Objective To observe the therapeutic effect of plaque radiotherapy (PRT) on choroidal melanoma. Methods PRT was performed on 21 patients (21 eyes) with chroidal melanoma who had been examined by ophthalmoscopy, fundus fluorescein angiography (FFA), indocyanine green angiography (ICGA), and B-scan echography. The visual acuity was le;0.05 in 3 eyes, 0.06-0.2 in 4 eyes, and ge;0.3 in 14 eyes before the treatment. Choroidal melanoma, round or oval brown solid hunch, was located at the area around macula in 7 eyes, around the optic disc in 7 eyes, at or near the vascular arcade in 5 cases, and at the periphery in 2 eyes. The maximum length、width and thickness of tumor was 13 mm, 11.6 mm, and 9.59 mm. The isotope we used was125I, and the quantum of designed radiation was 100-120 Gy. Fourteen patients with choroidal melanoma at the macular area or around the optic disc underwent plaque radiotherapy associated with transpupillary thermotherapy (TTT). The average follow-up duration was 12 months with the longest duration of 3 years. The basis and thickness (height) of tumors were measured by B-scan echography. The aggrandizement of the tumor would be regarded if the height increased 15% or the basis boundary aggrandized 250mm. Results The visual acuity after the treatment decreased in 9 eyes, remained unchanged in 10, and increased in 2. The dimension of tumo increased in 6 eyes, remained unchanged in 12, and decreased in 3. The complication was vitreous hemorrhage in 2 eys, vascular occlusion in 1, branch retinal venous occlusion in 1, macular pucker in 1, retinal hemorrhage in 3, partial optic atrophy in 3, neovascular glaucoma in 1, and extraction of eye in 3. Conclusion The domestic plaque design is effective on choroidal melanoma, and is of a sort on the thick tumor and the tumor located at macula or beside the optic disc. (Chin J Ocul Fundus Dis, 2006, 22: 157-160)

    Release date:2016-09-02 05:51 Export PDF Favorites Scan
  • Progression and challenge of therapeutic strategies in neovascular age-related macular degeneration

    Choroidal neovascularization (CNV) is the key characteristic of neovascular age-related macular degeneration (nAMD), and the effective therapy is intravitreal injection of anti-vascular endothelial growth factor (VEGF) agents based on clinical and basic research. In the meantime the challenge is how to further improve the inhibiting effect for CNV and visual function of anti-VEGF treatment on nAMD. The new strategy and drug delivery devices for anti-VEGF treatment will optimize the clinical scheme. From bench to bedside, the research on targeted treatment of angiogenesis brings the bloom of nAMD medical therapy.

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  • Radiotherapy for refractory choroidal hemangioma

    ObjectiveTo observe the effectiveness of radiotherapy for refractory choroidal hemangioma. MethodsEight patients (8 eyes) with choroidal hemangioma were enrolled in this retrospective study. All the patients had received laser or photodynamic therapy before without effectiveness. The patients included 7 males and 1 females. The age was ranged from 11 to 54 years old, with an average of (27.50±15.18) years. All the patients were affected unilaterally, including 3 right eyes and 5 left eyes. There were 5 eyes with circumscribed choroidal hemangioma, 3 eyes with diffused choroidal hemangioma. All eyes had extensively exudative retinal detachment. The vision was from light sensation to 0.01. The volume of the tumors was ranged from 1.96 to 5.35 cm3, with a mean of (3.37±1.06) cm3. All the patients were treated with X rays by conventional fractional radiotherapy. Four of 8 patients were applied 24Gy totally in 8 fractions, while the other 4 patients were applied 46Gy in 23 fractions. Follow-up period ranged from 7 to 95 months, with medium of 42 months. ResultsRetinas reattached in all the eyes while exudation being absorbed. No retinal detachment happened again. To the last follow-up, the vision was from light sensation to 0.6. Visual activity improved in 6 eyes while 2 eyes improved obviously. Visual acuity was stable in remaining 2 eyes. The volume of the tumors decreased to 1.24-2.16 cm3, with a mean of (1.68±0.30) cm3. The percentage of the tumor decreased by 14.6-72.7, with an average of (44.89±21.30)%. No radiotherapy-associated complication occurred. ConclusionRadiotherapy is an efficient and safe treatment for refractory choroidal hemangioma.

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  • 放化疗与单纯放疗治疗小细胞肺癌的疗效比较

    【摘要】 目的 比较放化疗与单纯放疗治疗小细胞肺癌的疗效差异。方法 2007年1月—2008年6月收治小细胞肺癌患者48例。在患者知情同意的前提下,随机分为放化疗结合组27例和单纯化疗组21例。观察并比较两组的治疗效果。结果 放化疗结合组和单纯化疗组总有效率分别为88.9%(24/27)和66.7%(14/21),放化疗结合组高于单纯化疗组(Plt;0.05)。放化疗结合组和单纯化疗组1年生存率分别为74.1%(20/27)和57.4%(12/21),放化疗结合组高于单纯化疗组(Plt;0.05)。结论 放化疗综合治疗小细胞肺癌可改善患者临床症状和生活质量,延长生存期。

    Release date:2016-09-08 09:37 Export PDF Favorites Scan
  • Therapeutic effects of eye-retaining treatment for choroidal melanoma

    Objective To evaluate the therapeutic effects of treatments of eye-retaining and enucleation for choroidal melanomas. Methods The clinical data of 44 patients (44 eyes) with choroidal melanomas after eye-retaining treatments and enucleation surgery were retrospectively analyzed. The metastasis, retention rate of eyeball after eye-retaining treatment, and visual acuity prognosis were observed and analyzed. In 44 eyes treated by eye-retaining therapy, transpupillary thermotherapy (TTT) was performed primaryly on 7 (15.9%), 106 Ru brachytherapy on 25 (56.8%), and local resection of tumor combined with 106 Ru brachytherapy on 12 (27.3%).The average follow-up period was 13.3 months. Results Forty-four patients had no melanoma metastasis during the follow-up period. In 39 patients (88.6%) who had their eyes retained successfully, the retention rate of eyeball was 100%, 92.9%, and 83.3% in 6, 14, and 24 eyes with small, middle, and large tumor, respectively. In the patients treated by eye-retaining therapy, the visual acuity was ge;0.3 in 11 (28.2%), ge;0.05-<0.3 in 18 (46.2%), and <0.05 (25.6%) in 10 eyes. Conclusions 106 Ru brachytherapy and transpupillary thermotherapy are effective treatments for small and medium-sized choroidal melanomas; some selected cases with large choroidal melanomas was treated with local resection of tumor combined with106 Rubrachytherapy. However, longer followup will be necessary to assess if this treatment has a better comprehensive outcome, compared with enucleation surgery. (Chin J Ocul Fundus Dis, 2006, 22: 150-153)

    Release date:2016-09-02 05:51 Export PDF Favorites Scan
  • 碘-125粒子支架植入治疗晚期食管癌

    目的 探讨附有放射碘125(125I)粒子的机织式支架植入治疗晚期食管癌的效果, 总结临床经验,以期为晚期食管癌患者的合理治疗提供临床依据。 方法 37例晚期食管癌患者应用附有125I粒子的机织式支架植入治疗,术中、术后观察随访支架植入成功率及并发症的发生率, 比较术前与术后3个月食管病变长度和白细胞计数的变化。 结果 37例患者手术过程顺利,支架植入成功率均为100%,仅3例患者胸部有明显疼痛不适感,经对症处理后缓解;随访6个月,随访33例,失访2例,死亡1例,因年龄偏大,体质较弱死亡。术后3个月,吞咽困难缓解率为100%,治疗后较治疗前食管病变长度明显缩小(Plt;0.05),而白细胞计数的变化差异无统计学意义 (Pgt;0.05)。 结论 附有125I粒子的机织式支架能明显改善吞咽困难症状,还可对肿瘤进行组织间放疗, 明显改善患者术后的生存质量。

    Release date:2016-08-30 06:05 Export PDF Favorites Scan
  • Treating choroidal melanoma by plaque radiotherapy combined with transpupillary thermotherapy

      Objective To observe the therapeutic efficacy and complications of plaque radiotherapy (PRT) combined with transpupillary thermotherapy (TTT) on choroidal melanoma (CM). Methods Thirty unilateral CM patients (30 eyes, including 15 males and 15 females) were treated by PRT and TTT. The visual acuity ranged from 0.1 to 0.8 with an average of 0.3plusmn;0.2. The largest base diameter of tumor ranged from 6.8 mm to 17.9 mm with an average of (11.3plusmn;2.8) mm;The tumor height ranged from 3.9 mm to 10.6 mm with an average of (7.2plusmn;2.4) mm. The criteria of controlled local tumor: based on B-scan ultrasound measurement, the tumor was considered as ldquo;growingrdquo; if tumor height increased 2 mm or tumor largest base diameter increased 250 mu;m, otherwise the tumor was considered ldquo;controlledrdquo;. The followup ranged from 15 to 57 months with an average (33.01plusmn;9.81) months. The local tumor control rate, enucleation rate and visual acuity, complications after treatment were observed.Results The tumor largest base diameter after treatment ranged from 4.6 mm to 17.0 mm with an average (9.79plusmn;3.35) mm, which had statistically significant difference(t=2.195,F=0.49;P=0.032) with that before treatment. The tumor height after treatment ranged from 2.7 mm to 11.9 mm with an average (5.19plusmn;2.57) mm, which had statistically significant difference(t=2.069,F=0.018;P=0.0435) with that before treatment. At the end of follow up, the tumor largest diameter and height increased in two eyes respectively compared with those before treatment. Local tumor control rate was 86.7%. Three eyeballs were enucleated after treatment,the enucleation rate was 10.0%. The visual acuity remained unchanged in 12 eyes,improved in one eye and decreased in 17 eyes. Treatment complications included radiation retinopathy in 12 eyes (40.0%), secondary retinal detachment in three eyes (10.0%), secondary glaucoma in one eye (3.3%), cataract in four eyes (13.3%) and dry eye syndrome in five eyes (16.7%). Conclusion PRT combined with TTT is an effective therapy for choroidal melanoma with less complications.

    Release date:2016-09-02 05:37 Export PDF Favorites Scan
  • Comparison of the Outcome of Complete Excision followed by Threedimensional Conformal Radiation Therapy and Adjuvant Chemotherapy versus Adjuvant Chemotherapy Alone in the Treatment of Patients with Stage ⅢA-N2 Non-small Cell Lung Cancer

    目的:探讨ⅢA-N2期非小细胞肺癌(NSCLC)完全切除术后三维适形放疗联合辅助化疗疗效。方法:对48例ⅢA-N2期NSCLC完全切除术后患者,术后病理为腺癌18例、鳞癌27例、腺鳞癌3例,按信封法随机分为放疗组(24例)与非放疗组(24例)。放疗组采用术后三维适形放疗,4~5个非共面野,以90%~95%等剂量曲线包绕PTV,每次2 Gy,1次/日,5次/周,共照射25次,总剂量DT 50 Gy,放疗后予TP方案化疗3~4周期;非放疗组术后予TP方案化疗3~4周期。结果:放疗组1、2、3年生存率分别为95.8%、79.2%、62.5%,非放疗组分别为91.7%、58.3%、37.5%;放疗组1、2、3年无病生存率分别75.0%、58.3%、45.8%,非放疗组分别为54.2%、41.7%、25.0%;放疗组与非放疗组3年胸腔内复发分别12.5%和37.5%;放疗组与非放疗组中位生存时间分别为28个月和18个月;放疗组白细胞减少、急性放射性肺炎、气管炎发生率分别为25.0%、8.3%、12.5%,均为Ⅰ或Ⅱ级;Ⅰ级急性放射性食管炎发生率为20.8%。结论:ⅢA-N2期非小细胞肺癌完全切除术后三维适形放疗联合辅助化疗,可以降低患者胸腔内肿瘤复发、提高术后生存率。

    Release date:2016-09-08 09:54 Export PDF Favorites Scan
  • 放射性视神经病变研究进展

      放射性视神经病变(RON)是因邻近视路的头颈部放射治疗(放疗)而引起的迟发性进行性视神经并发症。临床表现以突发的、无痛性单眼或双眼视力进行性下降为主要特征。视路接受的照射剂量及照射范围是发生RON的关键因素。增强的核磁共振成像(MRI)检查以及电生理检测具有一定的辅助诊断意义;结合其临床表现、相应辅助检查及头颈部放疗史可作出诊断。虽然高压氧治疗能在发病早期一定程度上改善RON的视力损害,但目前仍然缺乏行之有效的治疗方法。因此,在制定头颈部放疗计划时应充分考虑视神经、视交叉是否在照射范围内,并注意控制照射剂量,以防止RON的发生。

    Release date:2016-09-02 05:37 Export PDF Favorites Scan
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