Bacterial biofilms are associated with at least 80% of human bacterial infections. The clinical treatment of biofilm infection is still arduous, and therefore many new treatment options are under study, such as probiotics and their derivatives, quorum sensing inhibitors, antimicrobial peptides, phage therapy, organic acids, light therapy, and plant extracts. However, most of these schemes are not mature, and it is important to develop new research directions of anti-biofilms.
Ａ ｒｅｖｉｅｗ ｏｆ ｐａｔｉｅｎｔｓ ｗｉｔｈ ａｃｕｔｅ ｐａｎｃｒｅａｔｉｔｉｓ ｔｒｅａｔｅｄ ｉｎ ｔｈｉｓ ｈｏｓｐｉｔａｌ ｉｎ ｒｅｃｅｎｔ １０ ｙｅａｒｓ ｗａｓ ｍａｄｅ．Ｔｏ ｄｅｔｅｒｍｉｎｅ ｔｈｅ ｒｉｓｋ ｆａｃｔｏｒｓ ｏｆ ｓｅｐｔｉｃ ｎｅｃｒｏｓｉｓ ｉｎ ａｎｄ ａｒｏｕｎｄ ｔｈｅ ｐａｎｃｒｅａｓ，３２ ｃａｓｅｓ ｗｉｔｈ ｓｅｐｔｉｃ ｎｅｃｒｏｓｉｓ ｗｈｉｃｈ ｗｅｒｅ ｐｒｏｖｅｄ ｉｎ ｓｕｒｇｉｃａｌ ｏｐｅｒａｔｉｏｎ ａｎｄ ４４ ｃａｓｅｓ ｗｉｔｈｏｕｔ ｓｅｐｔｉｃ ｎｅｃｒｏｓｉｓ（ａｓ ｃｏｎｔｒｏｌ）ｗｅｒｅ ｉｎｃｌｕｄｅｄ ｉｎ ｔｈｉｓ ｓｔｕｄｙ．Ｔｈｅ ｐｏｓｓｉｂｌｅ ｆａｃｔｏｒｓ ｗｅｒｅ ｃｏｍｐａｒａｔｉｖｅｌｙ ａｎａｌｙｓｅｄ．Ｔｈｅ ｒｅｓｕｌｔｓ ｓｈｏｗｅｄ ｔｈａｔ ｓｅｐｔｉｃ ｎｅｃｒｏｓｉｓ ｉｎ ａｎｄ ａｒｏｕｎｄ ｔｈｅ ｐａｎｃｒｅａｓ ｏｂｖｉｏｕｓｌｙ ｒｅｌａｔｅｄ ｔｏ ｔｈｅ ｄｉａｇｎｏｓｔｉｃ ｏｒ ｔｈｅｒａｐｅｕｔｉｃ ｐｕｎｃｔｕｒｅｓ，ｅａｒｌｙ ｓｕｒｇｉｃａｌ ｄｒａｉｎａｇｅ ａｎｄ ｐａｒａｌｙｔｉｃ ｉｌｅｕｓ（ＯＲ ３０２－５４８，Ｐ＜００５)，ｂｕｔ ｔｈｅｒｅ ｗｅｒｅ ｎｏ ａｓｓｏｃｉａｔｉｏｎｓ ｗｉｔｈ ａｇｅ，ｅｔｉｏｌｏｇｙ，ｓｈｏｃｋ，ｒｅｓｐｉｒａｔｏｒｙ ｆａｉｌｕｒｅ ａｎｄ ｔｏｔａｌ ｐａｒｅｎｔｅｒａｌ ｎｕｔｒｉｔｉｏｎ（ＯＲ ０７８－１２６，Ｐ＞００５）．Ｔｈｅ ａｕｔｈｅｒｓ ｓｕｇｇｅｓｔ ｔｈａｔ ｅｉｔｈｅｒ ｐａｎｃｒｅａｔｉｃ，ｐｅｒｉｐａｎｃｒｅａｔｉｃ ｐｕｎｃｔｕｒｅ ｏｒ ｅａｒｌｙ ｓｕｒｇｉｃａｌ ｄｒａｉｎａｇｅ ｓｈｏｕｌｄ ｂｅ ｌｉｍｉｔｅｄ ａｎｄ ａｎｙ ｍｅｄｉｃａｔｉｏｎ ｗｈｉｃｈ ｍａｋｅｓ ｐａｒａｌｙｔｉｃ ｉｌｅｕｓ ｄｅｔｅｒｉｏｒａｔｅｄ ｓｕｃｈ ａｓ ａｔｒｏｐｉｎｅ ｓｈｏｕｌｄ ｂｅ ａｖｏｉｄｅｄ ｉｎ ｔｈｅ ｔｒｅａｔｍｅｎｔ ｏｆ ａｃｕｔｅ ｐａｎｃｒｅａｔｉｔｉｓ．
Objective To study the influence factors of surgical site infection (SSI) after hepatobiliary and pancreatic surgery. Methods Fifty patients suffered from SSI after hepatobiliary and pancreatic surgery who treated in Feng,nan District Hospital of Tangshan City from April 2010 and April 2015 were retrospectively collected as observation group, and 102 patients who didn’t suffered from SSI after hepatobiliary and pancreatic surgery at the same time period were retrospectively collected as control group. Then logistic regression was performed to explore the influence factors of SSI. Results Results of univariate analysis showed that, the ratios of patients older than 60 years, combined with cardiovascular and cerebrovascular diseases, had abdominal surgery history, had smoking history, suffered from the increased level of preoperative blood glucose , suffered from preoperative infection, operative time was longer than 180 minutes, American Societyof Anesthesiologists (ASA) score were 3-5, indwelled drainage tube, without dressing changes within 48 hours after surgery, and new injury severity score (NISS) were 2-3 were higher in observation group (P＜0.05). Results of logistic regression analysis showed that, patients had history of abdominal surgery (OR=1.92), without dressing changes within 48 hours after surgery (OR=2.07), and NISS were 2-3 (OR=2.27) had higher incidence of SSI (P＜0.05). Conclusion We should pay more attention on the patient with abdominal surgery history and with NISS of 2-3, and give dressing changes within 48 hours after surgery, to reduce the incidence of SSI.
Cardiac implantable electronic device (CIED) is commonly used to treat arrhythmias. The amount of CIED implantation has increased year by year since its first application in 1958. At the same time, the CIED infection rate also increases significantly. Although the infection rate is very low for the primary implantation, the consequences of CIED infection are serious, and it is often necessary to remove the equipment for treatment. The mortality rate in patients with CIED infections is high, and the economic burden is huge. In this paper, the epidemiology, pathogenesis and pathogen, manifestations and diagnosis, risk factors, treatment and preventive measures of CIED infection were systematically described based on the recently published guidelines and international consensus literature, so as to provide theoretical guidance for the prevention of CIED infections.
目的:探讨纤维支气管镜(简称纤支镜)肺泡灌洗术在治疗肺部感染性疾病的疗效。方法:共从内科系统中入选社区获得性肺炎和医院获得性肺炎患者122例,将其分为二组,治疗组:传统治疗加纤支镜肺泡灌洗术治疗肺部感染,共52例;对照组:传统方法治疗肺部感染,共70例。结果:两组病例在发热时间,咳嗽,咳痰及肺部罗音消失时间,住院日,抗生素使用时间,治愈率和死亡率方面对比均有显著性差异(Plt;0.05)。结论:纤支镜肺泡灌洗术在治疗肺部感染性疾病的疗效确切,且术中危险性小,值得推广。
Objective To investigate the effect of anti-infective reconstitutedbone xenograft (ARBX) as primary grafting on repair of a segmental contaminateddefect in canine radius. Methods The contaminated segmentaldefects of 1.5 cm were made in both radius of 8 canine and 1 ml of staphylococal suspension was injected into the defect region at a concentration of 5×106 CFU/ml. ARBX(experimental side) or RBX(control side) was implanted into the two sides of the defects respectively as primary grafting followed by internal fixation. The results were compared between the two grafting materials in repairing the contaminated segmental defect. Results In ARBX side, the defects were repaired completely in 5 cases and partially in 1 case, and there existed no osteomyelitis in all cases; while in RBX side, the defects were repaired partially in 1 case and were not repaired in 5 cases after 6 months of operation, and there existed osteomyelitis in all cases. Conclusion Besides its b osteoinductive and osteoconductive activity, ARBX is highly antibacterial and can be used as primary grafting in repairing contaminated segmental defects.