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find Author "吴强" 38 results
  • Müller细胞生理功能及其在糖尿病视网膜病变中的变化

    Müller细胞接触并包裹视网膜神经元细胞体和突触, 对视网膜神经元的功能及代谢起到支持作用; 对维护视网膜细胞外环境的稳定, 如离子、水平衡和血视网膜屏障(BRB)等具有重要调控作用; 可释放神经胶质递质和刺激性神经物质, 通过对神经递质的再吸收循环, 为视网膜神经元提供神经递质前体进而影响神经突触的活性。此外, Müller细胞对病理刺激能够产生反应。该反应一方面具有视网膜神经元保护作用, 如分泌神经营养因子、吸收降解兴奋性毒素、分泌抗氧化剂等, 另一方面也可引起视网膜神经元谷氨酸盐代谢紊乱和离子平衡紊乱, 导致视网膜水肿和神经元变性损伤。Müller细胞对糖尿病视网膜病变(DR)的发生发展具有重要影响。DR可引起Müller细胞增生, 除造成谷氨酸盐代谢紊乱外, 还会引起Müller细胞大量分泌炎症介质和血管内皮生长因子等破坏BRB。深入研究Müller细胞, 对探讨DR的发病及防治具有重要意义。针对Müller细胞靶向转染的腺病毒载体研制成功, 利用两亲肽携带蛋白或抗体直接转染细胞达到抑制DR的效果, 这些方法为早期防治DR提供了新的途径。

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  • 视紫红质类及卷曲蛋白受体在糖尿病视网膜病变发生发展中的作用

    鸟苷酸结合蛋白偶联受体(GPCRs)是一类膜受体超家族, 被视为最好的药物靶点。在糖尿病视网膜病变(DR)进程中有大量不同亚型GPCRs参与。其中, 视紫红质类和卷曲蛋白(Frizzled)受体广受关注, 研究方向主要为视网膜炎症反应、新生血管生成、神经元和神经胶质细胞损伤等。血管紧张素Ⅱ受体是最为熟知的视紫红质类受体亚家族。应用血管紧张素Ⅱ受体1拮抗剂可显著降低1型糖尿病患者发生DR的可能性, 但无法减缓已并发DR患者的病变进展; 可减缓并发轻中度DR的2型糖尿病患者的病变进展。其他的视紫红质类受体还有趋化因子受体、大麻素相关受体、GPR91、GPR109A、APJ受体等。Frizzled受体是Wnt信号通路重要的膜受体等。在DR动物模型中, 使用Wnt通路阻断剂Dickkopf homolog 1能改善视网膜炎症、血管渗出、新生血管生成等。但Wnt通路参与DR进展的具体机制有待研究。随着对GPCRs与DR关系了解的加深, 未来将有更多以GPCRs为治疗靶点的药物应用于临床, 为DR患者带来福音。

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  • 左心室部分切除减容术治疗终末期扩张型心肌病

    Release date:2016-08-30 06:33 Export PDF Favorites Scan
  • 半阻断升主动脉心内直视手术92例

    Release date:2016-08-30 06:32 Export PDF Favorites Scan
  • Clinical Comparative Study of Tension-Free Herniorrhaphy with Different Suture

    目的 观察运用两种不同缝线固定修补材料对疝修补术后的复发、切口感染、慢性疼痛等并发症发生情况。方法 对2008年4月至2010年4月期间笔者所在科室收治的250例腹股沟疝患者行无张力疝修补手术时,采用多股丝线或可吸收合成缝线固定修补材料进行前瞻性对比研究。结果 2组患者术后疝复发、切口感染和切口疼痛(包括慢性疼痛)发生率间的差异均无统计学意义(P>0.05)。结论 腹股沟疝无张力修补术后的复发、切口感染、慢性疼痛等并发症的发生与缝线选择无关。术者的操作技巧、严格的无菌操作原则、彻底止血以及组织损伤小才是防止术后感染、慢性疼痛等并发症发生的重要因素。

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  • A review of guidelines for diabetic retinopathy screening

    Diabetic retinopathy (DR) is the most common cause of preventable blindness in the working-age population. In addition to optimizing the hyperglycemia, hypertension, hyperlipidemia and other risk factors, regular fundus examination is essential for early diagnosis asymptomatic DR and timely treat the sight-threatening DR, so as to reduce blindness and severe visual impairment caused by DR. Clinical practice guidelines for the screening and management of DR have been implemented throughout the world, but there are reasonable differences between existing guidelines in the recommended timing of first retinal examination, screening intervals, methods for examination and criteria for referral to an ophthalmologist. It is of great clinical significance to have a detailed understanding of the current guidelines for DR screening and their clinical basis.

    Release date:2019-03-18 02:49 Export PDF Favorites Scan
  • Cause and Treatment of Chronic Pain after Tension-Free Repair of Inguinal Hernia

    Objective To explore the cause and treatment of chronic pain after tension-free repair of inguinal hernia. Methods 〗The clinical data of 426 cases with inguinal hernia underwent the tension-free hernioplasty during February 2002 to September 2007 were retrospectively analyzed. Results 〗Tension-free hernioplasty was performed to all patients. According to operative methods, they were divided into two groups: polypropylene filling group (n=210) and expanded polytetrafluoroethylene (e-PTFE) mycromesh group (n=216). The chronic pain rate after operation, polypropylene filling group (9.0%, 19/210) was significantly higher than e-PTFE mycromesh group (4.2%, 9/216), P<0.05. Conclusion 〗The tension-free repair by e-PTFE mycromesh has less pain in the inguinal hernia due to the material is more suitable to human physiology, more soft and light, with less complications.

    Release date:2016-09-08 10:57 Export PDF Favorites Scan
  • Investigation on Surgical Treatment of Abdominal Incisional Hernia(Analysis for 78 Cases)

    Objective To review the clinical operation methods of abdominal incisional hernia. Methods Classification, operation method and fellow-up of 78 patients with abdominal incisional hernia were retrospectively analyzed. Results The average time of fellow-up was 26 months. Nineteen cases were repaired with simple suture with 3 cases (15.8%) recurrence, 57 cases were repaired with man-made material with 2 case (3.4%) recurrence. Conclusions Individual operation method should be chosen according to body condition, classification of the size of abdominal loss and abdominal hypertension. It is an effective method to repair the hernia of abdominal incision with man-made material.

    Release date:2016-09-08 11:04 Export PDF Favorites Scan
  • 硅胶内衬套治疗地震挤压伤截肢术后1例报告

    目的:观察硅胶内衬套应用于地震挤压伤截肢术后患者残端渗液不止的治疗效果。方法:采用个案分析。14岁女性少年,因地震挤压伤致左小腿中上段截肢,给予综合康复治疗,伤口愈合后安装假肢,残端出现水泡,原伤口少量浆液性液体渗出不止,给予加戴硅胶内衬套。结果:患者残端伤口渗液逐渐减少,水泡消失,正常熟练使用假肢,日常生活活动能力提高,正常上学。结论:硅胶内衬套是处理截肢术后残端渗液较好的方法。

    Release date:2016-09-08 09:54 Export PDF Favorites Scan
  • 霉菌感染性视神经炎一例

    Release date:2017-09-19 03:09 Export PDF Favorites Scan
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