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find Keyword "创伤后" 26 results
  • 靶向脑源性神经营养因子/酪氨酸激酶 B 信号通路对癫痫的抑制

    创伤性脑损伤(Traumatic brain injury,TBI)和癫痫持续状态(Status epilepticus,SE)皆与人类癫痫的发生发展密切相关。虽病因不同,但目前的研究表明,这些损伤后癫痫发生的分子机制趋于一致。其中一个机制涉及脑源性神经营养因子(Brain-derived neurotrophic factor,BDNF)及其高亲和力受体酪氨酸激酶 B(Tropomyosin related kinase B,TrkB)。文章总结了 BDNF / TrkB 信号通路在癫痫发展中所起的病理生理学作用。轴突横断模型和 SE 动物模型分别模拟了人类 TBI 和 SE 后诱发的癫痫,在这两种动物模型的研究基础上,讨论了靶向 BDNF/TrkB 信号通路以减少癫痫发作及其导致的神经损伤的策略。

    Release date:2020-07-20 08:13 Export PDF Favorites Scan
  • A Study on the Psychological Health and Stress Disorder of Hospitalized Survivors of Zhouqu Debris Flow Disaster

    Objective To evaluate the psychological trauma incurred by the hospitalization survivor of Zhouqu district after the Zhouqu debris flow so as to provide relevant information for psychological and medical interventions. Methods The psychological state of 67 hospitalized survivors of the disaster and other 47 inpatients with similar complaints but not coming from the disaster area was investigated through a mental health self-assessment questionnaire, self-rating anxiety scale (SAS), self-rating depression scale (SDS) and PTSD-SS scale. Results The post-disaster survivors had different levels of psychological problems and post-traumatic stress disorder, and there were significant differences compared to the control group (Plt;0.01, Plt;0.01). The SDS score and the SAS score of the survivor were 48.44+15.648 and 52.92+11.672, respectively, which were all much higher than those of the control group (Plt;0.01, Plt;0.05). Conclusion The debris flow disaster bring serious psychological trauma to the victims. It is necessary to pertinently carry out post-disaster psychological relief including psychological intervention and regulation for the hospitalized survivors, so as to alleviate and reduce their psychological suffering.

    Release date:2016-09-07 11:02 Export PDF Favorites Scan
  • Effect of Mental Nursing for Operation Patients with Earthquake Trauma on Their Rehabilitation

    Objective To observe the effect of mental nursing for operation patients with earthquake trauma on their rehabilitation. Methods Eighty operation patients with earthquake trauma were randomly divided into two groups: mental nursing group and conventional nursing group. Psychological consult was used in the mental nursing group. Results were recorded by psychologic test, investigation questionnaire and nursing statistics. The measuring scales included SCL-90, HAMD and HAMA. Results The degree of satisfaction in the mental nursing group was obviously higher than that in the conventional nursing group. The scores of depression and anxiety in the mental nursing group were lower than these in the conventional nursing group. The length of hospital stay in the mental nursing group was also shorter (Plt;0.05). Conclusion  Mental nursing could reduce dysphrenia in operation patients with earthquake trauma and facilitate their rehabilitation.

    Release date:2016-09-07 02:11 Export PDF Favorites Scan
  • 创伤后应激障碍恢复力的研究进展

    个体在面临创伤性事件后是否发生创伤后应激障碍(PTSD)以及PTSD持续的时间与多种因素相关,可能有两方面决定个体的对创伤性事件的反应方向:一方面是发生PTSD的风险因素,另一方面是抵抗创伤性事件的反应和促进个体从创伤反应中恢复的恢复力。现对创伤抵抗与恢复起积极保护作用的恢复力的最新认识及其生物学机制和遗传学研究进行综述。

    Release date:2016-09-07 02:34 Export PDF Favorites Scan
  • MANAGEMENT OF RIGID POST-TRAUMATIC THORACOLUMBAR KYPHOSIS BY SIMULTANEOUS POSTERIO-ANTERIOR CIRCUMFERENTIAL RELEASING AND CORRECTION WITH PRESERVED POSTERIOR VERTEBRAL WALL

    【Abstract】 Objective To evaluate the surgical management of rigid post-traumatic thoracolumbar kyphosis (RPTK) by simultaneous posterio-anterior circumferential releasing, correction and anterior corpectomy with preserved posterior vertebral wall. Methods Twenty patients with RPTK were treated between October 2004 and October 2010 by posterior releasing, anterior subtotal corpectomy with preserved posterior vertebral wall, correction, strut graft, and short segmental fixation. There were 14 males and 6 females with an average age of 43.2 years (range, 23-63 years). The time between injury and operation was 4 months to 23 years (mean, 1.4 years). The affected locations were T11 in 1 case, T12 in 8 cases, L1 in 10 cases, and L2 in 1 case. The Cobb angle and the intervertebral height of the fractured vertebra body were measured before and after operations. The degrees of low back pain were assessed by Japanese Orthopaedic Association (JOA) scores. Results No incision infection, nerve injury, or cerebral spinal fluid leakage occurred. Seventeen patients were followed up 1-5 years with an average of 2.8 years. The JOA score at last follow-up (26.2 ± 3.9) was significantly improved when compared with the pre-operative score (14.0 ± 5.7) (t=4.536, P=0.001). One patient had aggravation of kyphosis at 3 months postoperatively, who was in stabilized condition after prolonging immobilizated time. The Cobb angle was corrected from (43.2 ± 11.5)° preoperatively to (9.8 ± 5.7)° at last follow-up, showing significant difference (P lt; 0.01). There was significant difference in the intervertebral height of the fractured vertebra body between preoperation and last follow-up (P lt; 0.05). The intervertebral height of fractured vertebra was restored to 87.0% ± 11.2% of adjacent disc height. Conclusion Posterio-anterior circumferential releasing and anterior corpectomy with preserved posterior vertebral wall can achieve satifactory clinical results, not only in pain relieving, kyphosis correction, vertebral height restoration, and spinal stability restoration, but also in the risk reduce of bleeding and spinal cord disturbance.

    Release date:2016-08-31 04:22 Export PDF Favorites Scan
  • Analysis on the characteristics of 837 patients with post-traumatic lower limb deformities from QIN Sihe Orthopaedic Surgery Database between May 25, 1978 and December 31, 2020

    Objective To summarize and analyze the characteristics and treatment strategies of post-traumatic lower limb deformity based on QIN Sihe Orthopaedic Surgery Database. Methods A clinical data of 837 patients with post-traumatic lower limb deformities treated by orthopaedic surgery between May 25, 1978 and December 31, 2020 in QIN Sihe Orthopaedic Surgery Database were analyzed retrospectively. The information of the patient’s gender, age at the time of surgery, region of origin, cause of trauma, deformity side, orthopedic surgery related information (operation time, location, type, and fixation method after operation) were summarized and analyzed. ResultsAll patients came from 32 provinces, municipalities, autonomous regions, and Taiwan in China. Among them, 551 cases (65.83%) were male and 286 cases (34.17%) were female. The age of the patients at the time of surgery was 3-84 years old, with an average of 27.6 years old, and the most patients were 16-45 years old (559 cases, 66.78%). The main cause of trauma was traffic accident injury (639 cases, 76.34%). The deformity mainly involved unilateral limbs, including 394 cases (47.07%) on the left side and 376 cases (44.92%) on the right side. The most patients were admitted between 2008 and 2017, accounting for 53.05% (444/837). All patients were operated on one or more sites (1 048 sites), among which ankle and toe surgery were the most, accounting for 48.38% (507/1 048). The patients received 1204 surgeries including tendon lengthening and soft tissue contracture release, et al. Orthopedic surgery combined with bone external fixation was used in 624 cases (467 cases of Ilizarov external fixation and 157 cases of combined external fixation), and plaster or brace external fixation was used in 213 cases. Conclusion Post-traumatic lower extremity deformity patients have a large proportion of males, with a wide geographical distribution, involving various parts of the lower extremities, and most commonly in the foot and ankle. Orthopedic surgery combined with bone external fixation (Ilizarov technique) is the main methods for correction and functional reconstruction of post-traumatic lower limb deformity.

    Release date:2022-08-29 02:38 Export PDF Favorites Scan
  • Study on Problems Related to Wenchuan Earthquake Disaster Psychological Traumas of People in Wenxian

    Objective To evaluate the psychological trauma incurred by the people in wenxian after the Wenchuan earthquake so as to provide relevant information for psychological and medical interventions. Methods Thepsychological state of the people after the earthquake was investigated using a mental health self-assessment questionnaire, self-rating anxiety scale, and self-rating depression scale. Results We found: 56.0% of the respondents were not happy, 39.6% often cried bitterly, 56.7% felt pain, 40.7% lost interest, 69.2% felt uneasy, nervous, or worried, and 27.0% would like to end their lives; the SDS scores (56.48±110.43) and SAS scores (39.88±11.38) of the people were significantly higher than those of the national norms (Plt;0.001). The following symptons appeared: 59.3% had headache, 50.5% poor appetite, poor sleeping 56.0%, 58.2% were easily frightened, tremors 29.7%, 50.5% dyspepsia, 42.9% thoughts fuzzy, 60.4% stomach discomfort, fatigue 85.7%. Conclusion The earthquake disaster brought about serious psychological harm to people. It is necessary to strengthen post-earthquake psychological relief and strengthen interventions in order to reduce the psychological suffering of victims.

    Release date:2016-09-07 02:09 Export PDF Favorites Scan
  • T Lymphocyte Subsets Analysis in Beichuan Patients with Rheumatoid Arthritis

    目的 探讨“5.12”地震后北川羌族人群中类风湿关节炎(RA)患者外周血 T细胞亚群的表达情况并分析创伤后应激障碍(PTSD)对RA患者细胞免疫之间的影响。 方法 2009年3月-2010年3月,对98例北川羌族RA患者、112例健康对照,以及同期绵阳郊区84例RA患者、120例健康对照进行分析。用流式细胞仪分别检测CD3+、CD3+CD4+、CD3+ CD8+ T淋巴细胞数及CD4/+CD8+比值, RA疾病活动性采用DAS28测定,应用美国精神障碍诊断与统计手册第4版(DSM-Ⅳ)诊断标准调查RA人群中的PTSD患者,应用PTSD检查表平时版(PCL-C)检查对PTSD患者进行分析。 结果 北川羌族与绵阳郊区RA活动组患者(分别为58例、39例)与健康对照组比较,CD8+ T淋巴细胞数降低,CD+4/CD8+比值增高,差异有统计学意义(P<0.05);北川羌族RA活动组与绵阳郊区RA活动组比较,CD3+ T淋巴细胞数降低,差异有统计学意义(P<0.05)。北川RA患者中PTSD者(38例)与非PTSD者(60例)比较,PTSD组CD3+ T淋巴细胞数和CD4+/CD+8比值均明显低于PTSD组,差异有统计学意义(P<0.05);PCL-C对北川RA患者中PTSD的测定发现,PCL高分组CD3+ T淋巴细胞数显著低于PCL低分组(P<0.05)。 结论 “5.12”地震后一部分RA患者出现T细胞免疫功能异常,且免疫功能异常与PTSD有关,对合并有PTSD的进行RA患者早期心理干预及药物治疗,改善患者生存质量。

    Release date:2016-09-08 09:11 Export PDF Favorites Scan
  • Report and Analysis of 90 Wounded Persons’ Sleep Disorders in Acute Stress in Yushu Earthquake

    【摘要】 目的 了解和分析玉树地震伤员急性应激期睡眠问题。 方法 2010年4月,对90例玉树地震伤员的急性应激反应采用创伤后应激障碍症状清单平民版(PCL-C)17项量表进行筛查评估,并应用SPSS 17.0软件进行统计学分析。 结果 在PCL-C 17个条目中,提示睡眠障碍的条目2和条目13发生率分别为61.10%、63.30%,分别排列第5位、第3位,其得分分别与PCL-C总得分、闪回症状得分、回避症状得分及高警觉性症状得分均呈正相关(P值均lt;0.01)。 结论 睡眠障碍是地震伤员急性应激反应中的常见问题,需高度重视,并进行积极有效的处理。【Abstract】 Objective To learn and analyze the sleep disorders in acute stress of the wounded persons in Yushu earthquake. Methods The acute stress reaction of 90 wounded persons in Yushu earthquake were screened with post-traumatic stress disorder (PTSD) Checklist-Civilian (PCL-C) version-17 in April 2010. Sleep disorders were statistically analyzed with SPSS 17.0. Results In the 17 items of PCL-C, the incidences of the second and the thirteenth item which were related to sleep disorders were respectively 61.10% ranking at the fifth and 63.30% ranking at the third. Both scores of these two items had significant positive correlation with the total score of PCL-C and the scores of the flashback symptom, the avoidance symptom and the heightened alertness symptom (Plt;0.01). Conclusion Sleep disorder is a common problem in acute stress reaction of wounded persons in earthquakes, which needs high attention to be treated positively.

    Release date:2016-09-08 09:24 Export PDF Favorites Scan
  • Hippocampal subfield volume alteration in post-traumatic stress disorder: a magnetic resonance imaging study

    In the current study, we aim to investigate whether post-traumatic stress disorder (PTSD) is associated with structural alterations in specific subfields of hippocampus comparing with trauma-exposed control (TC) in a relatively large sample. We included 67 PTSD patients who were diagnosed under Diagnostic and Statistical Manual of Mental Disorders (4th Edition) (DSM-Ⅳ) criteria and 78 age- and sex-matched non-PTSD adult survivors who experienced similar stressors. High resolution T1 weighted images were obtained via a GE 3.0 T scanner. The structural data was automatically segmented using FreeSurfer software, and volume of whole hippocampus and subfield including CA1, CA2-3, CA4-DG, fimbria, presubiculum, subiculum and fissure were extracted. Volume differences between the two groups were statistically compared with age, years of education, duration from the events and intracranial volume (ICV) as covariates. Hemisphere, sex and diagnosis were entered as fixed factors. Relationship between morphometric measurements with Clinician-Administered PTSD Scale (CAPS) score and illness duration were performed using Pearson’s correlation with SPSS. Comparing to TC, PTSD patients showed no statistically significant alteration in volumes of the whole hippocampus and all the subfields (P > 0.05). In male patients, there were significant correlations between CAPS score and volume of right CA2-3 ( R2 = 0.197, P = 0.034), right subiculum (R2 = 0.245, P = 0.016), and duration statistically correlated with right fissure (R2 = 0.247, P = 0.016). In female patients, CAPS scores significant correlated with volume of left presubiculum (R2 = 0.095, P = 0.042), left subiculum (R2 = 0.090, P = 0.048), and left CA4-DG (R2 = 0.099, P = 0.037). The main findings of the current study suggest that stress event causes non-selective damage to hippocampus in both PTSD patients and TC, and gender-specific lateralization may underlie PTSD pathology.

    Release date:2018-04-16 09:57 Export PDF Favorites Scan
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