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Nasal Endoscopic in the Treatment of Nasal Inverted Papilloma

目的：探讨鼻内镜手术治疗鼻内翻性乳头状瘤(NIP)的疗效。方法：回顾性分析用鼻内镜手术治疗的36例经病理确诊的NIP患者的临床资料，随访1～6年。结果:”一次性治愈31例(86.1%)；5例复发(13.9%)，3例在门诊内窥镜下分次摘除并结合YAG激光治愈，2例再次于鼻内镜结合Caidwell-Luc手术治疗，无恶变病例，结论：根据病变范围选择适当的手术方式，经鼻内镜手术切除鼻腔鼻窦内翻性乳头状瘤效果良好。

胰腺外实性假乳头状瘤1例报道

Diagnosis and Treatment of Solid Pseudopapillary Tumor of Pancreas (Reports of 8 Cases)

目的总结胰腺实性假乳头状瘤的临床特点及诊治体会。方法回顾性分析2000年5月至2010年5月期间在我科手术治疗并经病理检查证实的8例胰腺实性假乳头状瘤患者的临床资料。结果3例肿瘤位于胰头部者行胰十二指肠切除术; 2例肿瘤位于胰颈部者行单纯肿瘤摘除术; 1例肿瘤位于胰体部者行胰腺中段切除、近端闭合、远端与空肠行吻合术; 2例位于胰尾部者行胰体尾切除联合脾脏切除术。 术中未见腹腔脏器转移。8例患者术后经病理检查均证实为胰腺实性假乳头状瘤。 术后均未行放、化疗。 本组患者随访1~10年（平均5.5年），除2例失访外，其余均健在。 结论胰腺实性假乳头状瘤临床少见，属低度恶性肿瘤，女性多见； CT及MRI是其主要的影像学检查手段； 手术切除预后较好。

Correlation between Human Papilloma Virus Infection and Carcinogenesis of Esophageal Carcinoma in Minnan Population

ObjectiveTo detect human papilloma virus (HPV)infection with fluorescent quantitative real-time polymerase chain reaction (FQ-PCR)in Minnan population, and explore the correlation between HPV infection and carcinogenesis of esophageal carcinoma (EC)of Minnan patients. MethodsFQ-PCR was performed to examine HPV-6, HPV-11, HPV-16 and HPV-18 in 100 healthy Minnan people (healthy group, 66 males and 34 females with their age of 52.35±6.72 years)and 100 Minnan patients with squamous EC (EC group and tumor-adjacent normal tissue group, 64 males and 36 females with their age of 51.62±6.37 years)between October 2009 and December 2012. ResultsThe incidences of HPV infection in 100 EC tissues, 100 tumor-adjacent normal tissues and 100 esophageal mucosa tissues of healthy people were 22/100, 8/100 and 6/100 respectively, which were statistically different (χ2=10.63, P < 0.01). Positive infection of HPV-6, HPV-11, HPV-16 and HPV-18 was observed in 11 cases, 11 cases, 14 cases and 15 cases in EC group respectively, 5 cases, 6 cases, 7 cases and 8 cases in tumor-adjacent normal tissue group respectively, and 5 cases, 5 cases, 6 cases and 6 cases in the healthy group respectively (P > 0.05). Positive HPV infection was observed in 1 patients with well differentiated squamous EC, 21 patients with moderately differentiated squamous EC and 5 patients with poorly differentiated squamous EC (P > 0.05). ConclusionHPV infection may exist in tumor tissue of Minnan patients with squamous EC, and may be correlated with carcinogenesis and development of squamous EC.

Comparison of the Clinical Efficacy between Endoscopic Surgery and the Surgery Combined with Plasma Low-temperature Radiofrequency in Treating Papilloma of External Auditory Canal

目的　观察独用内镜下手术以及联合等离子低温射频治疗外耳道乳头状瘤的疗效。 方法　2006年7月－2010年7月，随机将收治的45例外耳道乳头状瘤患者（150只耳）分组，比较独用内镜下手术组（A组）以及联合等离子低温射频组（B组）治疗外耳道乳头状瘤的疗效。 结果　患者均术后成功随访1～3年，48只患耳无复发及恶变，2只患耳3个月后复发。 结论　内镜下手术联合等离子低温射频治疗外耳道乳头状瘤具有微创，手术彻底有效，防止复发的优点，值得临床广泛应用。

支气管乳突状瘤一例并文献复习

目的探讨支气管乳突状瘤的临床表现、病理学特征，诊断要点及治疗方式。方法分析 1 例呼吸道乳头状瘤的临床特征、影像及病理学资料，同时进行文献复习对该病进行分析总结。结果患者男性，73 岁，务农。因“呼吸困难半年”入院。本例患者胸部增强 CT 提示左主支气管起始部内见软组织密度影，支气管镜下行病理活检提示为支气管鳞状上皮乳头状瘤，人乳头状瘤病毒（HPV）阴性，Ki67（MIB-1）阳性。行纤维支气管镜下切除并给予重组人干扰素 α2b 注射液（假单胞菌）300 万 IU 皮下注射，治疗 7 d 后再次行纤维支气管镜下治疗好转后出院。通过以“乳头状瘤”与“支气管、气管、肺”为关键词检索查阅 CNKI、万方、维普等数据库，截止 2019 年 3 月。文献报道 93 例，患者年龄 19～80 岁，表现为咳嗽咳痰 60 例，咯血 38 例，胸闷或呼吸困难 31 例；位于气管、主气管 48 例；外科手术 43 例，支气管镜治疗 32 例；65 例患者有病理分型，其中鳞状细胞乳头状瘤 35 例、腺性乳头状瘤 10 例、混合型乳头状瘤 20 例。结论支气管乳突状瘤好发于中老年男性，与吸烟、HPV 感染相关。临床表现可无特异性，表现为咳嗽、咯血及呼吸困难等，容易误诊，诊断主要依据活组织病理检查，鳞状细胞乳头状瘤相对较多。支气管镜下介入治疗或手术治疗是有效的治疗手段，预后好，但易复发，需长期随访。

Diagnosis and Treatment of Solid-Pseudopapillary Tumor of Pancreas

目的　总结胰腺实性假乳头状瘤（solid-pseudopapillary tumor of pancreas, SPTP）的诊治经验。方法　回顾性分析我院1999年11月至2007年10月期间收治的6例SPTP患者的临床资料。结果　6例均为女性，其中4例为年轻女性； 术前均未确诊； 行胰腺体尾部切除2例，肿瘤局部切除4例，其中2例加脾切除，术后病理报告确诊为SPTP。 术后无严重并发症，随访1～95个月，无复发和转移。结论　SPTP多发于年轻女性，术中冰冻切片对术中处理提供参考，手术切除为首选治疗方法，预后良好。

宫颈癌与人乳头状瘤病毒相关研究进展

【摘要】　宫颈癌严重威胁女性健康，已成为发展中国家的第二位最常见的肿瘤死亡原因。宫颈癌的发生、发展与人乳头状瘤病毒感染密切相关，进一步明确人乳头状瘤病毒感染在宫颈癌发病机制中所起的作用，具有重大的研究价值。寻找宫颈癌早期的最佳筛查方案，研制有效的预防人乳头状瘤病毒感染疫苗将为人类攻克宫颈癌带来新的希望。

Comparative Study of Clinical Pathology of Solid-Pseudopapillary Tumor of The Pancreas and Islet Cell Tumor

Objective To investigate differential points of clinical symptoms and pathology of solid-pseudopapillary tumor of the pancreas (SPTP) and islet cell tumor (ICT). Methods Fifteen cases of SPTP and twelve cases of ICT were studied in this retrospective research. Clinical symptom, pathologic feature and computed tomography (CT) image of patients with both tumors were analyzed, and the imaging features were compared with pathological results. Results The mean age of SPTP patients was 22.4 year-old. Twelve patients with SPTP presented a palpable abdominal mass as the initial symptom. It was observed that the tumor cells were located in a pseudopapillary pattern with a fibro-vascular core histologically. On the CT images, a mixture of solid and cystic structures could be seen in all the tumors. After taking enhanced CT scan, the solid portion was slightly enhanced in the arterial phase and the contrast intensity increased in the portal venous phase. On the other hand, the mean age of ICT patients was 39.3 year-old. The major symptom was due to the function of islet cell tumor, which was typical in 8 patients, presenting as Whipple triad. Histologically, cells demonstrated in trabecular, massive, acinar or solid patterns, and the blood supply of the tumor was abundant. On the CT images, most small tumors were difficulty to be detected. ICT could be markedly enhanced in the arterial phase and slightly enhanced in the portal venous phase on post-contrast CT scan. Conclusion Clinical symptom, pathologic feature and CT scanning are helpful to differentiate SPTP from ICT.

MDT discussion of a case of solid pseudopapillary tumor of pancreas

ObjectiveTo improve recognization and effect of surgical treatment for solid pseudopapillary tumor of pancreas (SPTP) through multidisciplinary team (MDT) discussion.MethodsThe clinical data of 1 case of SPTP treated in The Second Affiliated Hospital of Chongqing Medical University were discussed by the MDT. The best operation scheme was selected and the patient was followed-up.ResultsThe preoperative CT scan showed that the occupation on the body and tail of pancreas and suggested it was the tumorous lesions. After the MDT discussion, the preoperative diagnosis was still not completely clear. However, the decision was made to resect occupation. After the operation, the pathological examination showed it was the SPTP. There was no recurrence or metastasis with the follow-up of 6 months.ConclusionsPreoperative diagnosis of SPTP is difficult, especially for atypical SPTP. Through MDT discussion, it can help to reduce misdiagnosis rate and formulate optimal surgical treatment strategy.