Relationship Between Expressions of HIF-1α and MMP-2 with Metastasis of Poorly Differentiated Gastric Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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陈振栋 , 吉志武 , 安树才 , 谭浪平

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Keywords：

缺氧诱导因子-1α; 基质金属蛋白酶-2; 胃低分化腺癌; 浸润转移; 免疫组化

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目的研究缺氧诱导因子-1α（HIF-1α）与基质金属蛋白酶-2（MMP-2）在低分化胃癌中的表达，并探讨两者在低分化胃癌浸润、转移过程中的相互关系及作用。
方法采用SP免疫组化方法，检测54例低分化胃癌及20例正常胃组织石蜡标本中HIF-1α和MMP-2蛋白表达水平。
结果低分化胃癌组织中HIF-1α和MMP-2蛋白表达阳性率明显高于正常胃组织（P lt;0.05）。两者的表达与肿瘤的浸润深度、淋巴转移和TNM分期均有关（P lt;0.05），HIF-1α与MMP-2的表达呈正相关（r=0.580, P lt;0.05）。
结论 HIF-1α和MMP-2在低分化胃癌的侵袭、转移过程中存在一定的协同作用，两者可能成为判断胃癌预后的指标。

Citation： 陈振栋,吉志武,安树才,谭浪平. Relationship Between Expressions of HIF-1α and MMP-2 with Metastasis of Poorly Differentiated Gastric Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2010, 17(2): 187-188. doi: Copy

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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Relationship Between Expressions of HIF-1α and MMP-2 with Metastasis of Poorly Differentiated Gastric Cancer

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