Relation Between Blood Neutrophil-to-Lymphocyte Ratio and Prognostic of Patients with Gastrointestinal Stromal Tumor and Its Clinical Significance_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

JIN Xin ¹ , FENG Li ² , LI Fuguang ¹ , YANG Chenglin ¹ ,  WANG Ning ¹

1.Department of General Surgery， Ankang Central Hospital， Ankang 725000， Shaanxi Province， China;;
2.Department of Anorectal， Ankang Central Hospital， Ankang 725000， Shaanxi Province， China;

Corresponding author：

WANG Ning, Email: scyclb@126.com

Keywords：

Neutrophil-to-lymphocyte ratio; Gastrointestinal stromal tumor; Prognosis

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Abstract Full text Figures/Tables Video References Cited by

Objective 　To investigate preoperative blood neutrophil-to-lymphocyte ratio （NLR） in patients with gastrointestinal stromal tumor （GIST） and analyze the relationship of the NLR to prognosis.
Methods 　The data of NLR of peripheral blood samples on 3d before surgery and the results of immunohistochemistry of 42 patients with GIST were analyzed respectively，the relation between the NLR and the prognosis of patients with GIST was understood by the survival analysis.
Results 　The patients with high NLR （NLR≥2.5） was found in 22 cases， low NLR （NLR＜2.5） in 20 cases.The NLR was related to mitotic figures （χ2=9.45，P=0.002） and tumor size （P=0.041）. The 3-year survival rate of the patients with high NLR was shorter than that of the low NLR （χ2=5.44，P=0.022）. The 3-year survival rate was associated with NLR，mitotic figures，and tumor size （P＜0.05） in univariate analysis. The NLR and mitotic figures were independent prognostic indicators of 3-year survival （P=0.018，P=0.000） in Cox multivariate analysis.
Conclusion 　Blood NLR and mitotic figures have some predictive value for the prognosis of patients with GIST.

Citation： JIN Xin,FENG Li,LI Fuguang,YANG Chenglin,WANG Ning. Relation Between Blood Neutrophil-to-Lymphocyte Ratio and Prognostic of Patients with Gastrointestinal Stromal Tumor and Its Clinical Significance. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2013, 20(8): 910-914. doi: Copy

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1. Delahaye NF， Rusakiewicz S， Martins I， et al. Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors[J]. Nat Med， 2011， 17(6)：700-707.
2. 马晋平，王智，林建伟，等. 中性粒细胞/淋巴细胞比值在胃癌预后评估中的应用[J]. 中华胃肠外科杂志， 2012， 14(12)：944-947.
3. Ohno Y， Nakashima J， Ohori M， et al. Pretreatment neutrophil-to-lymphocyte ratio as an independent predictor of recurrence in patients with nonmetastatic renal cell carcinoma[J]. J Urol， 2010， 184(3)：873-878.
4. Fletcher CD， Berman JJ， Corless C， et al. Diagnosis of gastrointestinal stromal tumors a consensus approach[J]. Hum Pathol， 2002， 33(5)：459-465.
5. 卢震海，伍小军，方淯靖，等. 胃肠间质瘤的外科治疗及预后分析[J]. 中华胃肠外科杂志， 2011， 14(10)：778-780.
6. 张洪静，黄娟，敖平，等. 64层螺旋CT对胃间质瘤的诊断价值[J]. 中国普外基础与临床杂志， 2012， 19(8)：885-889.
7. Balkwill F， Mantovani A. Inflammation and cancer：back to Virchow?[J]. Lancet， 2001， 357(9255)：539-545.
8. Kryczek I， Wei S， Szeliga W， et al. Endogenous IL-17 contributesto reduced tumor growth and metastasis[J]. Blood， 2009， 114(2)：357-359.
9. Maheswaran S， Haber DA. Circulating tumor cells：a window into cancer biology and metastasis[J]. Curr Opin Genet Dev， 2010， 20(1)：96-99.
10. Coussens LM， Werb Z. Inflammation and cancer[J]. Nature， 2002， 420(6917)：860-867.
11. Schmidt H， Suciu S， Punt CJ， et al. Pretreatment levels of perip-heral neutrophils and leukocytes as independent predictors of overall survival in patients with American Joint Committee onCancer StageⅣMelanoma：results of the EORTC 18951 Bioche-motherapy Trial[J]. J Clin Oncol， 2007， 25(12)：1562-1569.
12. Donskov F， Bennedsgaard KM， Hokland M， et al. Leukocyte orchestration in blood and tumour tissue following interleukin-2 based immunotherapy in metastatic renal cell carcinoma[J]. Cancer Immunol Immunother， 2004， 53(8)：729-739.
13. Teramukai S， Kitano T， Kishida Y， et al. Pretreatment neutrophilcount as an independent prognostic factor in advanced non-small-cell lung cancer：an analysis of Japan Multinational Trial Organisation LC00-03[J]. Eur J Cancer， 2009， 45(11)：1950-1958.
14. Kitayama J， Yasuda K， Kawai K， et al. Circulating lymphocyte number has a positive association with tumor response in neoadjuvant chemoradiotherapy for advanced rectal cancer[J]. Radiat Oncol， 2010， 5：47.
15. Ding PR， An X， Zhang RX， et al. Elevated preoperative neutro-phil to lymphocyte ratio predicts risk of recurrence following cura-tive resection for stageⅡA colon cancer[J]. Int J Colorectal Dis，.
16. Kishi Y， Kopetz S， Chun YS， et al. Blood neutrophil-to-lym-phocyte ratio predicts survival in patients with colorectal liver metas-tases treated with systemic chemotherapy[J]. Ann Surg Oncol， 2009， 16(3)：614-622.
17. Balachandran VP， Cavnar MJ， Zeng S， et al. Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido[J]. Nat Med， 2011， 17(9)：1094-1100.
18. Di Carlo E， Forni G， Musiani P. Neutrophils in the antitumoral immune response[J]. Chem Immunol Allergy， 2003， 83：182-203.
19. McMillan DC. Systemic inflammation， nutritional status and survival in patients with cancer[J]. Curr Opin Clin Nutr Metab Care， 2009， 12(3)：223-226.
20. Harris RE. Cyclooxygenase-2 (cox-2) blockade in the chemoprevention of cancers of the colon， breast， prostate， and lung[J]. Inflammopharmacology， 2009， 17(2)：55-67.
21. 李权林，任明扬. 非甾体类抗炎药抗肿瘤机理的研究进展[J]. 中国普外基础与临床杂志， 2012， 19(12)：1368-1371.
22. Amin AR. The metabolomics of nitric oxide and reactive nitrogen species in immune editing tumor milieu：influence of nitric oxide-modulating therapies[J]. J Drug Metab Toxicol， 2012， S8. doi：10.4172/2157-7609. S8-002.
23. García-Rodríguez LA， Huerta-Alvarez C. Reduced risk of colorectal cancer among long-term users of aspirin and nonaspirin nonsteroidal antiinflammatory drugs[J]. Epidemiology， 2001， 12(1)：88-93.
24. Aerts NE， De Knop KJ， Leysen J， et al. Increased IL-17 produc-tion by peripheral T helper cells after tumour necrosis factor bloc-kade in rheumatoid arthritis is accompanied by inhibition of migration-associated chemokine receptor expression[J]. Rheumatology， 2010， 49(12)：2264-2272.
25. Vaish V， Sanyal SN. Chemopreventive effects of NSAIDs on cytokines and transcription factors during the early stages of colorectal cancer[J]. Pharmacol Rep， 2011， 63(5)：1210-1221.
26. Lesterhuis WJ， de Vries IJ， Schuurhuis DH， et al. Vaccination of colorectal cancer patients with CEA-loaded dendritic cells：antigen-specific T cell responses in DTH skin tests[J]. Ann Oncol，.
27. ， 17(6)：974-980.
28. ， 25(12)：1427-1433.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Relation Between Blood Neutrophil-to-Lymphocyte Ratio and Prognostic of Patients with Gastrointestinal Stromal Tumor and Its Clinical Significance

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