肿瘤坏死因子β基因多态性与冠心病_West China Medical Journal

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肿瘤坏死因子β; 基因多态性; 冠心病

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肿瘤坏死因子β(tumor necrosis factor β,TNF-β)是一种多生物活性的前炎性细胞因子,在血栓形成和动脉粥样硬化等发病机制中起重要作用。在最近几年的研究中TNF-β基因多态性被证实是与冠心病密切相关的基因之一,本文旨在阐述TNF-β及其受体结构、功能、相关基因多态性以及国内外对该位点基因多态性研究进展。

Citation： 徐良成综述高大胜审校. 肿瘤坏死因子β基因多态性与冠心病. West China Medical Journal, 2009, 24(9): 2487-2489. doi: Copy

1.	OZAKI K, OHNISHI Y, YAMADA R, et al. Functional SNPs in the lymphotoxina gene that are associated with susceptibility to myocardial infarction[J]. Nat Genet,2002,32:650-654..
2.	TANAKA T, OZAKI K. Inflammation as a risk factor for myocardial infarction[J].Hum Genet,2006,51(7):595-604..
3.	MATTHIAS G, GUDRUN Z, EVA G, et al. Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: a role for TNFR1 activation by endogenous membraneanchored TNF[J]. EMBO J,1999,18(11):3034-3043..
4.	DINARELLO C A, CANAOR J G, WOIF S M, et al． Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1[J]. Exp Med,1986,163:1433..
5.	TALMUD P J. Geneenvironment interaction and its impact on coronary heart disease risk[J]. Nutr Metab Cardiovasc Dis,2007,17(2):148-152..
6.	COPE A P. Regulation of autoimmunity by proinflammatory cytokines[J]. Curr Opin Immunol,1998,10:669-676..
7.	SCHREYER S A, VICK C M, LEBOEUF R C. Loss of lymphotoxinɑ but not tumor necrosis factorɑ reduces atherosclerosis in mice[J]. Biol Chem,2002,277:12364-12368..
8.	PROCARDIS CONSORTIUM. A trio family study showing association of the lymphotoxina N26(804A) allele with coronary artery disease[J]. Eur J Human Genetics,2004,12:770-774..
9.	LAXTON R. Association of the lymphotoxinα gene Thr26Asn polymorphism with severity of coronary atherosclerosis[J]. Genes Immun,2005,6(6):539-541.
10.	李艳,汪明,张平安,等.肿瘤坏死因子β基因G252A、C804A多态性与冠状动脉粥样硬化性心脏病的相关性[J].中华医学遗传学杂志,2004,21(6):583-586..
11.	赵文强,王俊,谢红珍,等.LTA 804C/A基因变异与冠心病易感性、严重度和分子标志物之间的关系[J].中国心血管杂志,2008,13(1):17-20..
12.	YAMADA A, ICHIHARA S, MURASE Y, et al. Lack of association of polymorphisms of the lymphotoxin α gene with myocardial infarction in Japanese[J].Mol Med,2004,82:477-483..
13.	KOCH W, HOPPMANN P, MICHOU E, et al. Association of variants in the BAT1NFKBIL1LTA genomic region with protection against myocardial infarction in Europeans[J]. Hum Mol Genet,2007,16(15):1821-1827..
14.	KOCH W, TIROCH K, VON B N, et al. Tumor necrosis factorα, lymphotoxinα, and interleukin10 gene polymorphisms and restenosis after coronary artery stenting[J]. Cytokine,2003,24:161-171..
15.	SEDLACEK K, NEUREUT HER K, MUELLER J C, et al. Lymphotoxinα and galectin2 SNPs are not associated with myocardial infarction in two different German populations[J]. Mol Med,2007,85(9):997-1004..
16.	BROWN B, LAWRENCE R, CHENG S, et al. Lack of association between premature myocardial infarction and the lymphotoxina C804A polymorphism in a UK discordant sibling population[J].2006,Hum Genet In press..
17.	CLARKE R, XU P, BENNETT D, et al. Lymphotoxinα gene and risk of myocardial infarction in 6 928 cases and 2 712 controls in the ISIS casecontrol study[J]. PloS Genetics,2006,2(7):e107..
18.	KIMURA A, TAKAHASHI M, CHOI B Y, et al. Lack of association between LTA and LGALS2 polymorphisms and myocardial infarction in Japanese and Korean populations[J]. Tissue Antigens,2007,69(3):265－269..

1. OZAKI K, OHNISHI Y, YAMADA R, et al. Functional SNPs in the lymphotoxina gene that are associated with susceptibility to myocardial infarction[J]. Nat Genet,2002,32:650-654..
2. TANAKA T, OZAKI K. Inflammation as a risk factor for myocardial infarction[J].Hum Genet,2006,51(7):595-604..
3. MATTHIAS G, GUDRUN Z, EVA G, et al. Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: a role for TNFR1 activation by endogenous membraneanchored TNF[J]. EMBO J,1999,18(11):3034-3043..
4. DINARELLO C A, CANAOR J G, WOIF S M, et al． Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1[J]. Exp Med,1986,163:1433..
5. TALMUD P J. Geneenvironment interaction and its impact on coronary heart disease risk[J]. Nutr Metab Cardiovasc Dis,2007,17(2):148-152..
6. COPE A P. Regulation of autoimmunity by proinflammatory cytokines[J]. Curr Opin Immunol,1998,10:669-676..
7. SCHREYER S A, VICK C M, LEBOEUF R C. Loss of lymphotoxinɑ but not tumor necrosis factorɑ reduces atherosclerosis in mice[J]. Biol Chem,2002,277:12364-12368..
8. PROCARDIS CONSORTIUM. A trio family study showing association of the lymphotoxina N26(804A) allele with coronary artery disease[J]. Eur J Human Genetics,2004,12:770-774..
9. LAXTON R. Association of the lymphotoxinα gene Thr26Asn polymorphism with severity of coronary atherosclerosis[J]. Genes Immun,2005,6(6):539-541.
10. 李艳,汪明,张平安,等.肿瘤坏死因子β基因G252A、C804A多态性与冠状动脉粥样硬化性心脏病的相关性[J].中华医学遗传学杂志,2004,21(6):583-586..
11. 赵文强,王俊,谢红珍,等.LTA 804C/A基因变异与冠心病易感性、严重度和分子标志物之间的关系[J].中国心血管杂志,2008,13(1):17-20..
12. YAMADA A, ICHIHARA S, MURASE Y, et al. Lack of association of polymorphisms of the lymphotoxin α gene with myocardial infarction in Japanese[J].Mol Med,2004,82:477-483..
13. KOCH W, HOPPMANN P, MICHOU E, et al. Association of variants in the BAT1NFKBIL1LTA genomic region with protection against myocardial infarction in Europeans[J]. Hum Mol Genet,2007,16(15):1821-1827..
14. KOCH W, TIROCH K, VON B N, et al. Tumor necrosis factorα, lymphotoxinα, and interleukin10 gene polymorphisms and restenosis after coronary artery stenting[J]. Cytokine,2003,24:161-171..
15. SEDLACEK K, NEUREUT HER K, MUELLER J C, et al. Lymphotoxinα and galectin2 SNPs are not associated with myocardial infarction in two different German populations[J]. Mol Med,2007,85(9):997-1004..
16. BROWN B, LAWRENCE R, CHENG S, et al. Lack of association between premature myocardial infarction and the lymphotoxina C804A polymorphism in a UK discordant sibling population[J].2006,Hum Genet In press..
17. CLARKE R, XU P, BENNETT D, et al. Lymphotoxinα gene and risk of myocardial infarction in 6 928 cases and 2 712 controls in the ISIS casecontrol study[J]. PloS Genetics,2006,2(7):e107..
18. KIMURA A, TAKAHASHI M, CHOI B Y, et al. Lack of association between LTA and LGALS2 polymorphisms and myocardial infarction in Japanese and Korean populations[J]. Tissue Antigens,2007,69(3):265－269..

West China Medical Journal

肿瘤坏死因子β基因多态性与冠心病

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