The Relationship between the Implantation of Ovarian Stimulated Embryos and the Expression of Leukemia Inhibitory Factor Protein in Mice Metrium_West China Medical Journal

Authors：

1.Assisted Reproductive Medical Center, General Hospital of Jinan Military Region, Jinan 250031; 2.the Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu 6100041, China;

Corresponding author：

Keywords：

超排卵; 妊娠率; 胚胎着床率; Lif蛋白

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观察受体鼠妊娠和胚胎着床情况,并检测胚胎移植时小鼠子宫内膜中白血病抑制因子(Lif)表达水平,探讨超排卵对小鼠胚胎着床潜能的影响。方法:建立超排周期胚胎和自然周期胚胎移植小鼠模型,比较妊娠率、胚胎着床率的差异及其与Lif蛋白的表达水平之间的关系。结果:超排卵周期受体组的妊娠率(20.00%)和胚胎着床率(8.33%)显著低于自然周期组的妊娠率(55.00%)和胚胎着床率(35.00%)(P＜0.05)。自然周期胚胎和超排周期胚胎受体组内膜中Lif蛋白的表达水平相似(P＞0.05),妊娠受体组Lif蛋白的表达水平显著高于未孕受体组(P＜0.05),但单胎妊娠和多胎妊娠受体组内膜中Lif蛋白的表达水平相似(P＞0.05)。结论:超排卵可能降低胚胎的着床潜能,Lif蛋白的表达水平与胚胎着床有关,但与着床胚胎的数目无比例关系。

Citation： LI PeiXu,LI Shangwei,PENG Zhilan,et al.. The Relationship between the Implantation of Ovarian Stimulated Embryos and the Expression of Leukemia Inhibitory Factor Protein in Mice Metrium. West China Medical Journal, 2009, 24(9): 2370-2372. doi: Copy

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1. KIMBER S J. Leukaemia inhibitory factor in implantation and uterine biology[J]. Reproduction,2005,130(2):131-145..
2. KRALICKOVA M, SIMA R, VANECEK T, et al. Leukemia inhibitory factor gene mutations in the population of infertile women are not restricted to nulligravid patients[J]. Eur J Obstet Gynecol Reprod Biol,2006,127(2):231-235..
3. DING T, SONG H, WANG X, et al. Leukemia inhibitory factor ligandreceptor signaling is important for uterine receptivity and implantation in golden hamsters (Mesocricetus auratus) [J]. Reproduction,2008,135(1):41-53..
4. SCHOFIELD G, KIMBER S J. Leukocyte subpopulations in the uteri of leukemia inhibitory factor knockout mice during early pregnancy[J]. Biol Reprod,2005,72(4):872-878..
5. MARWOOD M, VISSER K, SALAMONSEN L A, et al. Interleukin11 and leukemia inhibitory factor regulate the adhesion of endometrial epithelial cells: implications in fertility regulation[J]. Endocrinology,2009,150(6):2915-2923..
6. PERRIERD H S, CHARLETRENARD C, BERNDT S, et al. Human chorionic gonadotropin and growth factors at the embryoendometrial interface control leukemia inhibitory factor (LIF) and interleukin 6 (IL6) secretion by human endometrial epithelium[J]. Hum Reprod,2004,19(11):2633-2643..
7. AGHAJANOVA L, ALTME S, BJURESTEN K, et al. Disturbances in the LIF pathway in the endometrium among women with unexplained infertility[J]. Fertil Steril,2009,91(6):26022610.

West China Medical Journal

The Relationship between the Implantation of Ovarian Stimulated Embryos and the Expression of Leukemia Inhibitory Factor Protein in Mice Metrium

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