Dosimetry Comparison of 3-dimensional Conformal Radiation Therapy and Intensity Modulated Radiation Therapy Plans for Cervical Carcinoma after Radical Surgery_West China Medical Journal

Authors：

1Radiation and Physics Center; 2the Department of Abdominal Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

Keywords：

宫颈癌; 放疗; 3DCRT; IMRT; 剂量学

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目的:比较宫颈癌术后的三维适形放疗(3D-CRT)和调强放射治疗(IMRT)放射治疗计划的剂量学差异。方法:使用Elekta公司的PrecisePLAN Release2.11计划系统设计常规四箱形野(3D-CRT)和调强放疗(IMRT)计划。通过剂量体积直方图比较二者的放射物理参数,评价其应用价值.结果:IMRT计划中靶区平均剂量略高于3D-CRT计划中的相应值,其靶区适形度明显占优。同时,IMRT计划中的膀胱、直肠、小肠、股骨头等危险器官受到的平均剂量低于3D-CRT计划中的相应值,除右股骨头受到的平均剂量差异没有统计学意义,其它数据的差异都具有统计学意义。结论:对于宫颈癌术后患者的放射治疗,IMRT技术在保证肿瘤放射剂量的同时最大限度地减少了危险器官的照射剂量,减少了并发症的发生,应该更广泛地应用于临床。

Citation： LI Tao,JIANG Xiaoqin,BAI Sen,et al. Dosimetry Comparison of 3-dimensional Conformal Radiation Therapy and Intensity Modulated Radiation Therapy Plans for Cervical Carcinoma after Radical Surgery. West China Medical Journal, 2009, 24(8): 2098-2101. doi: Copy

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1.
2.
3. PORTELANCE L, CHAO K S, GRIGSBY P W, et al. Intensitymodulated radiationtherapy (IMRT) reduces small bowel, rectum, and bladder doses in patients with cervical cancer receiving pelvic and paraaortic irradiation[J]. Int J Radiat Oncol Biol Phys,2001,51(1):261-266.
4. MUNDT A J, LUJAN A E, ROTMENSCH J, et al. Intensitymodulated whole pelvic radiotherapy in women with gynecologic malignancies[J]. Int J Radiat Oncol Biol Phys,2002,52:1330-1337.
5. 张书旭.宫颈癌调强放疗和三维适形放疗剂量对比研究[J].中国医学物理学杂志,2004,21(5):252-254.
6. 胡逸民.肿瘤放射物理学[M].北京:原子能出版社,1999:337-338.
7. 殷蔚伯,谷铣之.肿瘤放射治疗学[M].第3版.北京:北京医科大学中国协和医科大学联合出版社,2002.
8. CAGLAR H B, ALLEN A M. Intensitymodulated radiotherapy for head and neck cancer[J]. Clin Advances Hematol Oncol,2007,5(6):425-431.
9. STEIN M E, BOEHMER D, KUTEN A. Radiation therapy in prostate cancer[J]. Recent Results Cancer Res,2007,175(3):179-199.
10. LEFKOPOULOS D, FERREIRA I, ISAMBERT A, et al. Present and future of theimage guided radiotherapy (IGRT) and its applications in lung cancer treatment[J]. Cancer Radiother,2007,11(1-2):23-31.
11. KROCHAK R J, BAKER D G. Radiation nephritis. Clinical manifestationsand pathophysiologic mechanisms[J]. Urology,1986,27(5):389-393.
12. SHARMA M, SHARMA R, GE X L, et al. Early detection of radiationinduced glomerular injury by albumin permeability assay[J]. Radiat Res,2001,155(3):474-480.
13. AHMED R S, KIM R Y, DUAN J, et al. IMRT dose escalation for positive para aortic lymph nodes in patients with locally advanced cervical cancer while reducing dose to bone marrow and other organs at risk[J]. Int J Radiat Oncol Biol Phys,2004,60(2):505-512.
14. KELLER REICHENBECHER M A, BORTFELD T, LEVEGRUN S, et al. Intensity modulation with the “step and shoot” technique using a commercial MLC: a planning study[J]. Int J Radiat Oncol Biol Phys,1999,45(5):1315-1324.

West China Medical Journal

Dosimetry Comparison of 3-dimensional Conformal Radiation Therapy and Intensity Modulated Radiation Therapy Plans for Cervical Carcinoma after Radical Surgery

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