Objective To investigate the efficacy and safety of polyethersulfone highflux dialyzer for uremic patients.
Methods Forty eligible uremic patients were randomized into two groups, i.e. polyethersulfone (PES) group and polysulfone(PSF) group, according to a random number table. The PES group received hemodialysis for 4 hours with polyethersulfone highflux dialyzer (Chengdu OCI Medical Device Co., Ltd), and the PSF group with polysulfone highflux dialyzers (Fresenius Polysulfones, Fresenius Medical Care, Bad Homburg, Germany). Changes in serum creatinine, urea, β2-microglobulin, hemoglobin and albumin levels were determined for efficacy and safety evaluation.
Results All the 40 patients completed the trial. The serum creatinine, urea, β2-microglobulin levels of all the patients in the two groups decreased ( gt;30%) after the hemodialysis with different highflux dialyzers, and no significant difference was observed between the two groups (P gt;0.05). Changes in solute clearance index (KT/V) value, hemoglobin and albumin levels were also comparable between the two groups (P gt;0.05).
Conclusions The efficacy and safety of the PES hollow fiber membrane hemodialyzer is equivalent to that of the PSF hemodialyzer in hemodialysis for uremic patients.
Citation：
SU Baihai,LI Zi,TAO Ye,SHA Zhaohui,FU Ping,ZHAO Changsheng. A Clinical Trial of Polyethersulfone Highflux Dialyzer for Uremic Patients. Chinese Journal of Evidence-Based Medicine, 2006, 06(7): 474-478. doi:
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- 2. 郝继英, 王质刚. 高通量透析的临床研究. 肾脏病与透析肾移植杂志, 1998; 7(2): 130~133, 204.
- 3. Lipps B, Stewart R, Perkins H, et al. The hollow fiber artificial kidney. Trans Am Soc Artif Intern Org, 1969; 13: 200-207.
- 4. Morti S, Shao JH, Zydney AL. Importance of asymmetric structure in determining mass transport characteristics of hollow fiber hemodialyzers. J Membrane Sci, 2003; 224: 39-49.
- 5. Baeyer HV, Lajous-Petter A, Debrandt W, et al. Surface reactions on blood contact during hemodialysis and haemofiltration with various membrane types. J Membrane Sci, 1988; 36: 215-222.
- 6. Zhao CS, Liu T, Lu ZP, et al. An evaluation of a polyethersulfone hollow fiber plasma separator by animal experiment. Artif Organs, 2001; 25(1): 60-63.
- 7. In: Wang ZG, ed. Blood Purification. 2nd Edition. Beijing: Beijing science technique publishing company; 2005.
- 8. Hao JY, Wang ZG. Clinical Evaluation of Highly Permeable Dialysis. J Nephrol Dialy Transplant, 1998; 7(2): 130-133, 204.
