The authors studied retrospectively clinical data of seventy cases with breast cancer during pregnancy and lactation.They were treated and diagnosed by operation and pathology.Primary factors influencing prognosis were analyzed.It was demonstrated that 5year survival rate of the patients were significantly influenced by clinical stage , month of pregnancy and lactation, time of symptoms, type of operation, type of pathology, histological grade of malignancy, recurrence and metastasis, and estrogen receptor status (Ｐ＜0.05).Age and termination of pregnancy had no beneficial effect on survival (Ｐ＞0.05).The prognosis of pregnant and lactating breast cancer was poorer than ordinary breast cancer.Their 5year survival rate were 55.7% and 74.3%, respectively. After they were matched for stage and for age, no difference in survival was found.Early diagnosis and radical operation combined with radiotherapy, chemotherapy and hormonal therapy have better prognosis.The method can shorten time of treatment and improve survival rate.Termination of pregnancy has not been shown to improve survival and shall not be advised routinely.Future pregnancy may be detrimental and shall be discouraged.
Citation：
Chen Guoji,Shao Yongfu,Yu Hongtiao.. ANALYSIS OF FACTORS INFLUENCING PROGNOSIS OF BREAST CANCER ASSOCIATED WITH PREGNANCY AND LACTATION. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1999, 6(1): 33-35. doi:
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- 1. Petrek JA. Breast cancer during pregnancy. Cancer, 1994; 74(1)∶518.
- 2. Elledge RM, Ciocca DR, Langone G, et al. Estrogen receptor, progesterone receptor, and HER2/neu protein in breast cancer from pregnant patients. Cancer, 1993; 71(8)∶2499.
- 3. 曹月敏， 王国佩主编. 乳腺外科学. 石家庄： 河北科学技术出版社， 1991∶323～326.
- 4. Lethaby AE, O Neill MA, Mason BH, et al. Overall survival from breast cancer in women pregnant of lactating at or after diagnosis. Int J Cancer, 1996; 67(6)∶751.
- 5. Difronzo LA, O Connell TX. Breast cancer in pregnancy and lactation. Surg Clin North Am, 1996; 76(2)∶267.
- 6. Petrek JA, Dukoff R, Rogatko A. Prognosis of pregnancyassociated breast cancer. Cancer, 1991; 67(4)∶869.
- 7. Petrek JA. Pregnancy safety after breast cancer. Cancer, 1994; 74(1)∶528.
- 8. ScottConner CEH, Schorr SJ. The diagnosis and management of breast problems during pregnancy and lactation. Am J Surg, 1995; 170(4)∶401.
