Methodological recommendations in the topic selection and question formulation of integrated traditional Chinese and Western medicine clinical practice guideline_Chinese Journal of Evidence-Based Medicine

Authors：

WANG Jianxin ^1,2 , GAO Xuemin ³ , LI Rui ^4,5 , SHI Qi ^1,3 , DAI Xinyue ^1,2 ,  GAO Rui ^1,2

1. Xiyuan Hospital Affiliated to China Academy of Chinese Medical Sciences, Beijing 100091, P. R. China;
2. National Medical Products Administration for Laboratory for Clinical Research and Evaluation of Traditional Chinese Medicine, Beijing 100091, P. R. China;
3. Beijing University of Chinese Medicine, Beijing 100105, P. R. China;
4. The First Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou 50000, P. R. China;
5. Henan Evidence Based Chinese Medicine Center, Zhengzhou 450000, P. R. China;

Corresponding author：

GAO Rui, Email: ruigao@126.com

Keywords：

Integrated traditional Chinese and Western medicine; Evidence-based clinical practice guideline; Guide theme; Clinical problem

DOI：

10.7507/1672-2531.202501003

Video：

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Construct clinical questions is the basis in developing the evidence-based clinical practice guidelines. The identification of the topics and clinical questions in the evidence-based clinical practice guidelines of integrated traditional Chinese and Western medicine is the most challenging procedure in the process of developing guidelines, but there is still a lack of systematic formulation process and methodological recommendations. This article takes the construction of the topics and clinical questions of the "Clinical Application Guidelines for the Prevention and Treatment of Acute Pharyngitis with Integrated Traditional Chinese and Western Medicine" as an example, expounds the process and methodological suggestions for the construction of the topics and clinical questions, so as to provide a reference for the formulation and improve the quality and clinical applicability of the evidence-based clinical practice guidelines of integrated traditional Chinese and Western medicine.

Citation： WANG Jianxin, GAO Xuemin, LI Rui, SHI Qi, DAI Xinyue, GAO Rui. Methodological recommendations in the topic selection and question formulation of integrated traditional Chinese and Western medicine clinical practice guideline. Chinese Journal of Evidence-Based Medicine, 2025, 25(10): 1191-1196. doi: 10.7507/1672-2531.202501003 Copy

1.	中西医联合防治策略标准研究项目组. 《中西医联合防治优势病种临床应用指南》制订技术规范. 中国中西医结合杂志, 2024, 44(4): 389-398.
2.	靳英辉, 韩斐, 王强, 等. 临床实践指南制订方法—指南范围、主题及问题的确定. 中国循证心血管医学杂志, 2018, 10(3): 257-261.
3.	Jin YH, Wang YP, Xie YL, et al. Research on the development methodology for clinical practice guidelines for organic integration of traditional Chinese and Western medicine. Mil Med Res, 2023, 10(1): 45.
4.	陈薇, 刘建平. 中西医结合临床实践指南制订原则和流程. 中国中西医结合杂志, 2022, 42(12): 1413-1417.
5.	白英哲, 王烨燃, 黄璐琦. 中医疾病名称的特征、存在问题与研究思路. 中医杂志, 2024, 65(7): 661-668.
6.	赵国桢, 宗星煜, 赵学尧, 等. 中医证候分类标准形成的关键技术及方法学思考. 中国实验方剂学杂志, 2024, 30(24): 257-261.
7.	中华医学会, 中华医学会杂志社, 中华医学会全科医学分会, 等. 急性上呼吸道感染基层诊疗指南(2018年). 中华全科医师杂志, 2019, 18(5): 422-426.
8.	《中成药治疗优势病种临床应用指南》标准化项目组. 中成药治疗小儿急性上呼吸道感染临床应用指南(2020年). 中国中西医结合杂志, 2021, 41(2): 143-150.
9.	姚晓燕, 边永君, 高扬, 等. 《中医药单用/联合抗生素治疗急性咽炎疾病临床实践指南》临床应用评价与修订意见. 中国中药杂志, 2018, 43(24): 4765-4770.
10.	Huang Y, Wu T, Zeng L, et al. Chinese medicinal herbs for sore throat. Cochrane Database Syst Rev, 2012, (3): CD004877.
11.	李泽鹏, 李文建, 孙志佳. 中成药治疗急性咽炎数据挖掘及网状Meta分析. 山东大学耳鼻喉眼学报, 2023, 37(4): 111-118.
12.	Aertgeerts B, Agoritsas T, Siemieniuk RAC, et al. Corticosteroids for sore throat: a clinical practice guideline. BMJ, 2017, 358: j4090.
13.	van Driel ML, De Sutter AI, Thorning S, et al. Different antibiotic treatments for group A streptococcal pharyngitis. Cochrane Database Syst Rev, 2021, (3): CD004406.
14.	Ebell MH, Barry HC. Management of sore throat: time to update. Am Fam Physician, 2024, 109(4): 301-302.
15.	Krüger K, Töpfner N, Berner R, et al. Clinical practice guideline: sore throat. Dtsch Arztebl Int, 2021, 118(11): 188-194.
16.	张霞, 谢雁鸣, 李光熙, 等. 中医药治疗急性咽炎的优势与问题探讨. 中国中药杂志, 2017, 42(19): 3819-3825.
17.	田晨, 刘雅菲, 卢婷婷, 等. 中西医结合快速推荐指南技术与方法. 中国中西医结合杂志, 2025, 45(4): 389-396.
18.	张莉莉, 薛崇祥, 周凌, 等. 由靶及态之现代中西医结合医学模式探析. 中医杂志, 2023, 64(22): 2269-2274.
19.	谢伊, 林洪生, 张英. 基于医学发展史探索中西医结合方法与途径. 中国中西医结合杂志, 2023, 43(11): 1375-1379.
20.	彭蓉晏, 孙凌云, 刘稼玺, 等. 基于改良德尔菲法构建《早中期结直肠癌根治术后中西医结合心理康复干预指南》临床问题. 中国中西医结合杂志, 2024, 44(8): 912-920.
21.	靳英辉, 阎思宇, 任相颖, 等. 《中西医融合临床实践指南制订规范》解读. 医学新知, 2024, 34(12): 1319-1328.
22.	高一城, 刘芷含, 夏如玉, 等. 中医药临床实践指南临床问题构建中干预措施的优先性选择—基于专家证据的方法学建议. 中国循证医学杂志, 2023, 23(4): 433-438.
23.	王雅琪, 高一城, 苏澄元, 等. 临床实践指南中临床问题结构化分级及评价. 中国循证医学杂志, 2024, 24(7): 827-831.
24.	Pelucchi C, Grigoryan L, et al. Guideline for the management of acute sore throat. Clin Microbiol Infect, 2012, 18(Suppl 1): 1-28.
25.	National Institute for Health and Care Excellence. Sore throat (acute): antimicrobial prescribing. 2018.
26.	陈思语, 郭孟杨, 邓江红, 等. A族链球菌咽炎的临床诊断及评分制的应用进展. 中国当代儿科杂志, 2024, 26(8): 893-898.
27.	陈耀龙, 罗旭飞, 史乾灵, 等. 人工智能如何改变指南的未来. 协和医学杂志, 2021, 12(1): 114-121.
28.	Sousa-Pinto B, Marques-Cruz M, Neumann I, et al. Guidelines international network: principles for use of artificial intelligence in the health guideline enterprise. Ann Intern Med, 2025, 178(3): 408-415.
29.	Sousa-Pinto B, Vieira RJ, Marques-Cruz M, et al. Artificial intelligence-supported development of health guideline questions. Ann Intern Med, 2024, 177(11): 1518-1529.

1. 中西医联合防治策略标准研究项目组. 《中西医联合防治优势病种临床应用指南》制订技术规范. 中国中西医结合杂志, 2024, 44(4): 389-398.
2. 靳英辉, 韩斐, 王强, 等. 临床实践指南制订方法—指南范围、主题及问题的确定. 中国循证心血管医学杂志, 2018, 10(3): 257-261.
3. Jin YH, Wang YP, Xie YL, et al. Research on the development methodology for clinical practice guidelines for organic integration of traditional Chinese and Western medicine. Mil Med Res, 2023, 10(1): 45.
4. 陈薇, 刘建平. 中西医结合临床实践指南制订原则和流程. 中国中西医结合杂志, 2022, 42(12): 1413-1417.
5. 白英哲, 王烨燃, 黄璐琦. 中医疾病名称的特征、存在问题与研究思路. 中医杂志, 2024, 65(7): 661-668.
6. 赵国桢, 宗星煜, 赵学尧, 等. 中医证候分类标准形成的关键技术及方法学思考. 中国实验方剂学杂志, 2024, 30(24): 257-261.
7. 中华医学会, 中华医学会杂志社, 中华医学会全科医学分会, 等. 急性上呼吸道感染基层诊疗指南(2018年). 中华全科医师杂志, 2019, 18(5): 422-426.
8. 《中成药治疗优势病种临床应用指南》标准化项目组. 中成药治疗小儿急性上呼吸道感染临床应用指南(2020年). 中国中西医结合杂志, 2021, 41(2): 143-150.
9. 姚晓燕, 边永君, 高扬, 等. 《中医药单用/联合抗生素治疗急性咽炎疾病临床实践指南》临床应用评价与修订意见. 中国中药杂志, 2018, 43(24): 4765-4770.
10. Huang Y, Wu T, Zeng L, et al. Chinese medicinal herbs for sore throat. Cochrane Database Syst Rev, 2012, (3): CD004877.
11. 李泽鹏, 李文建, 孙志佳. 中成药治疗急性咽炎数据挖掘及网状Meta分析. 山东大学耳鼻喉眼学报, 2023, 37(4): 111-118.
12. Aertgeerts B, Agoritsas T, Siemieniuk RAC, et al. Corticosteroids for sore throat: a clinical practice guideline. BMJ, 2017, 358: j4090.
13. van Driel ML, De Sutter AI, Thorning S, et al. Different antibiotic treatments for group A streptococcal pharyngitis. Cochrane Database Syst Rev, 2021, (3): CD004406.
14. Ebell MH, Barry HC. Management of sore throat: time to update. Am Fam Physician, 2024, 109(4): 301-302.
15. Krüger K, Töpfner N, Berner R, et al. Clinical practice guideline: sore throat. Dtsch Arztebl Int, 2021, 118(11): 188-194.
16. 张霞, 谢雁鸣, 李光熙, 等. 中医药治疗急性咽炎的优势与问题探讨. 中国中药杂志, 2017, 42(19): 3819-3825.
17. 田晨, 刘雅菲, 卢婷婷, 等. 中西医结合快速推荐指南技术与方法. 中国中西医结合杂志, 2025, 45(4): 389-396.
18. 张莉莉, 薛崇祥, 周凌, 等. 由靶及态之现代中西医结合医学模式探析. 中医杂志, 2023, 64(22): 2269-2274.
19. 谢伊, 林洪生, 张英. 基于医学发展史探索中西医结合方法与途径. 中国中西医结合杂志, 2023, 43(11): 1375-1379.
20. 彭蓉晏, 孙凌云, 刘稼玺, 等. 基于改良德尔菲法构建《早中期结直肠癌根治术后中西医结合心理康复干预指南》临床问题. 中国中西医结合杂志, 2024, 44(8): 912-920.
21. 靳英辉, 阎思宇, 任相颖, 等. 《中西医融合临床实践指南制订规范》解读. 医学新知, 2024, 34(12): 1319-1328.
22. 高一城, 刘芷含, 夏如玉, 等. 中医药临床实践指南临床问题构建中干预措施的优先性选择—基于专家证据的方法学建议. 中国循证医学杂志, 2023, 23(4): 433-438.
23. 王雅琪, 高一城, 苏澄元, 等. 临床实践指南中临床问题结构化分级及评价. 中国循证医学杂志, 2024, 24(7): 827-831.
24. Pelucchi C, Grigoryan L, et al. Guideline for the management of acute sore throat. Clin Microbiol Infect, 2012, 18(Suppl 1): 1-28.
25. National Institute for Health and Care Excellence. Sore throat (acute): antimicrobial prescribing. 2018.
26. 陈思语, 郭孟杨, 邓江红, 等. A族链球菌咽炎的临床诊断及评分制的应用进展. 中国当代儿科杂志, 2024, 26(8): 893-898.
27. 陈耀龙, 罗旭飞, 史乾灵, 等. 人工智能如何改变指南的未来. 协和医学杂志, 2021, 12(1): 114-121.
28. Sousa-Pinto B, Marques-Cruz M, Neumann I, et al. Guidelines international network: principles for use of artificial intelligence in the health guideline enterprise. Ann Intern Med, 2025, 178(3): 408-415.
29. Sousa-Pinto B, Vieira RJ, Marques-Cruz M, et al. Artificial intelligence-supported development of health guideline questions. Ann Intern Med, 2024, 177(11): 1518-1529.

Chinese Journal of Evidence-Based Medicine

Methodological recommendations in the topic selection and question formulation of integrated traditional Chinese and Western medicine clinical practice guideline

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