Objective To investigate the effects of alcohol consumption status and labor intensity on the tolerance of patients undergoing bronchoscopy under mild to moderate sedation anesthesia. Methods Adult patients scheduled for bronchoscopy under local anesthesia or mild to moderate sedation were included, and their clinical characteristics and bronchoscopy tolerance were recorded. The study compared changes in vital signs, severity of coughing, and procedure failure rates during bronchoscopy among patients with different drinking statuses (non-drinkers, former drinkers, and current drinkers) and different labor intensities (light, moderate, and heavy labor intensity) to assess the impact of drinking status and labor intensity on bronchoscopy tolerance.Results A total of 142 subjects were included in the study, with 50 patients receiving local anesthesia and 92 patients receiving mild to moderate sedation. Current drinkers had a higher procedure failure rate (2.9% vs. 1.9% vs. 25.0%, P<0.01, for non-drinkers, former drinkers, and current drinkers, respectively) and more significant intraoperative blood pressure drops (systolic pressure change, −3.5±9.1 vs. −0.2±8.1 vs. −9.3±17.9 mm Hg, P<0.01; diastolic pressure change, −0.5±5.6 vs. 2.9±7.9 vs. −3.2±12.4, P<0.05). Patients with moderate to heavy labor intensity also had higher procedure failure rates and more pronounced intraoperative blood pressure drops (procedure failure rate, 1.1% vs. 13.2% vs. 22.2%, P<0.01, for light, moderate, and heavy labor intensity, respectively; intraoperative systolic pressure change, −1.8±8.5 vs. 2.8±8.5 vs. −17.2±24.7 mm Hg, P<0.001; intraoperative diastolic pressure change, 1.3±6.4 vs. 0.2±6.7 vs. −8.1±17.2 mm Hg, P<0.01). The impact of drinking status and labor intensity on procedure tolerance was only observed in patients receiving mild to moderate sedation. After controlling for relevant confounding factors, current drinking and moderate to heavy labor intensity were identified as independent risk factors for procedure failure (current drinkers compared to non-drinkers or former drinkers, OR 47.2, 95%CI: 3.1-232.2, P<0.05; moderate to heavy labor intensity compared to low labor intensity, OR 25.7, 95%CI: 2.8-67.7, P<0.05).Conclusions Current drinkers engaged in moderate to heavy labor intensity are less likely to tolerate bronchoscopy under mild to moderate sedation. It is essential to pay attention to the selection and evaluation of anesthesia methods, procedure types, and intraoperative monitoring for this population.

Citation： LI Xiaolong, HU Yun, DU Wei. Drinkers engaged in moderate to high-intensity work are less tolerant to bronchoscopy under mild to moderate sedation. Chinese Journal of Respiratory and Critical Care Medicine, 2025, 24(8): 556-563. doi: 10.7507/1671-6205.202503070 Copy

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