Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma Misdiagnosed as Pulmonary Tuberculosis:A Case Report and Literature Review_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

XingXiqian ¹ , WeiXing ¹ , YangZhijian ¹ , WangLiqiong ² , ZhangYuxuan ¹ , LiYanli ¹ , WuXuwei ¹ ,  YangJiao ³

1. First Department of Respiratory Medicine, Yan'an Hospital Affiliated to Kunming Medical University, Kunming, Yunnan, 650051, China;
2. ;
3. ;

Corresponding author：

YangJiao, Email: yangjiaokmu@yahoo.com

Keywords：

Pulmonary mucosa-associated lymphoid tissue lymphoma; Clinical manifestation; Imaging features

DOI：

10.7507/1671-6205.2016086

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Objective To improve the knowledge of pulmonary mucosa-associated lymphoid tissue (MALT)lymphoma. Methods A patient diagnosed as pulmonary MALT lymphoma was reported and related literatures were reviewed. Results The patient was a 58-year-old male,admitted due to intermittent fever,cough,sputum production,chest tightness and fatigue for 4 years.The patient was diagnosed as "pulmonary tuberculosis and tuberculous pleurisy" in other hospital and received anti-tuberculosis treatment for 3 years.The CT of the chest showed consolidation in the right middle lobe,right low lobe and left lower lobe with bronchial ventilation levy,miliary nodules in the right middle lobe,interstitial thickening,and right pleural effusion.Ultrasound guided lung biopsy pathology of the right lung showed diffuse small lymphocytes infiltration.The immunohistochemistry showed positive staining of CD20,CD79α and Vim,and weakly positive staining of Ki67(15%).Therefore,the patient was finally diagnosed pulmonary MALT lymphoma. Conclusions Pulmonary MALT lymphoma has no specific clinical manifestations,so is easy to be misdiagnosed as pulmonary tuberculosis,pneumonia or lung cancer.The patients with suspicious pulmonary MALT lymphoma should undergo percutaneous lung biopsy,transbronchial lung biopsy or open lung biopsy as soon as possible for immunohistochemistry staining to confirm the diagnosis.

Citation： XingXiqian, WeiXing, YangZhijian, WangLiqiong, ZhangYuxuan, LiYanli, WuXuwei, YangJiao. Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma Misdiagnosed as Pulmonary Tuberculosis:A Case Report and Literature Review. Chinese Journal of Respiratory and Critical Care Medicine, 2016, 15(4): 365-367. doi: 10.7507/1671-6205.2016086 Copy

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1. Kim JH,Lee SH,Park J,et al.Primary pulmonary non-Hodgkin's lymphoma.Jpn J Clin Oncol,2004,34:510-514.
2. Ahmed S,Siddiqui AK,Rai KR.Low-grade B-cell bronchial associated lymphoid tissue (BALT)lymphoma.Can Inves,2002,20:1059-1068.
3. Chow WH,Cucheine Y,Hilfer J,et al.Chronic pneumonia primary malignant non Hodgkin's lymphoma of the lung arising in mucosa associated lymphoid tissue.Chest,1996,110:838-842.
4. 梁小燕, 李洪霞,蔡少华.肺黏膜相关淋巴组织淋巴瘤23例临床分析.中国呼吸与危重监护杂志,2015,14:477-481.
5. 赵毅超, 张丽琴,黄来全,等.肺黏膜相关淋巴组织淋巴瘤一例分析并文献复习.中国呼吸与危重监护杂志,2015,14:395-397.
6. Huang H,Lu ZW,Jiang CG,et al.Clinical and prognostic characteristics of pulmonary mucosa-associated lymphoid tissue lymphoma:a retrospective analysis of 23 cases in a Chinese population.Chin Med J(Engl),2011,124:1026-1030.
7. Ogusa E,Tomita N,Ishii Y,et al.Clinical manifestations of primary pulmonary extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue in Japanese population.Hematol Oncol,2013,31:18-21.
8. 闵严旭, 李惠民,肖湘生.肺淋巴瘤的CT与X线表现.临床放射学杂志,1998,17:270-272.

Chinese Journal of Respiratory and Critical Care Medicine

Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma Misdiagnosed as Pulmonary Tuberculosis:A Case Report and Literature Review

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