A bibliometric analysis of nanoparticles in the treatment of non-small cell lung cancer_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

XU Xiangyu ^1,2,3 , YUAN Lei ^1,2,3 , SUN Fei ^1,2,3 , SHEN Zhiming ^1,2,3 , SHAN Yibo ^1,2,3 , LU Yi ^1,2,3 , ZHU Jianwei ^1,2,3 , CHEN Wenxuan ^1,2,3 ,  SHI Hongcan ^1,2,3

1. Clinical Medical College, Yangzhou University, Yangzhou, 225009, Jiangsu, P. R. China;
2. Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, 225009, Jiangsu, P. R. China;
3. Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou University, Yangzhou, 225009, Jiangsu, P. R. China;

Corresponding author：

SHI Hongcan, Email: shihongcan@yzu.edu.cn

Keywords：

Nanoparticles; non-small cell lung cancer; bibliometrics; visualization

DOI：

10.7507/1007-4848.202212017

Video：

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Objective To analyze the current research application status and hotspots of nanoparticles in the treatment of non-small cell lung cancer (NSCLC) and predict the future development trend. Methods The Web of Science database was searched for literatures on nanoparticles use in the treatment of NSCLC from inception to November 2022. CiteSpace, VOSviewer and literature measurement analysis online platform (https://bibliometric.com/) were used for the visual analysis of the number of documents, source journals, authors, organizations, countries and keywords. Results A total of 742 English literatures were included. The results showed that the number of published literatures increased year by year from 2011 and reached the peak in 2020. Researches on nanoparticles and NSCLC treatment were mainly concentrated in China, the United States, India and Japan. China is a major research country in this field, but it lacked cooperation with other countries and related institutions. Among numerous research institutions, the Chinese Academy of Sciences was the authoritative and backbone force in this research field, with the number of published literatures ranking first and the research achievements outstanding. The keyword analysis found that "poly lactic-co-glycolic acid nanoparticles (PLGA NPs)" and "photothermal therapy" had become the latest breakout words since 2018. Moreover, the occurrence frequency of related keywords such as "drug delivery" increased significantly, indicating that the application of PLGA NPs in photothermal therapy might be the current research hotspot and future development trend of NSCLC treatment. Conclusion Currently, the domestic research on the treatment of nanoparticles and NSCLC is in a leading position in the world. The organic combination of nanoparticles with different materials and other NSCLC therapies is expected to improve the prognosis of NSCLC patients. In the future, attempts to develop nanoparticles with different sources and structures and combined with photothermal therapy for the treatment of NSCLC may become a research hotspot of nanoparticles in the treatment of NSCLC.

Citation： XU Xiangyu, YUAN Lei, SUN Fei, SHEN Zhiming, SHAN Yibo, LU Yi, ZHU Jianwei, CHEN Wenxuan, SHI Hongcan. A bibliometric analysis of nanoparticles in the treatment of non-small cell lung cancer. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2024, 31(8): 1139-1147. doi: 10.7507/1007-4848.202212017 Copy

1.	Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2024, 74(3): 229-263.
2.	Herbst RS, Morgensztern D, Boshoff C. The biology and management of non-small cell lung cancer. Nature, 2018, 553(7689): 446-454.
3.	Thai AA, Solomon BJ, Sequist LV, et al. Lung cancer. Lancet, 2021, 398(10299): 535-554.
4.	Ruiz-Cordero R, Devine WP. Targeted therapy and checkpoint immunotherapy in lung cancer. Surg Pathol Clin, 2020, 13(1): 17-33.
5.	Li S, Xu S, Liang X, et al. Nanotechnology: Breaking the current treatment limits of lung cancer. Adv Healthc Mater, 2021, 10(12): e2100078.
6.	Pi C, Zhao W, Zeng M, et al. Anti-lung cancer effect of paclitaxel solid lipid nanoparticles delivery system with curcumin as co-loading partner in vitro and in vivo. Drug Deliv, 2022, 29(1): 1878-1891.
7.	Sun Y, Yang J, Li Y, et al. Single low-dose INC280-loaded theranostic nanoparticles achieve multirooted delivery for MET-targeted primary and liver metastatic NSCLC. Mol Cancer, 2022, 21(1): 212.
8.	张绍元, 林淼, 汪灏, 等. 食管癌手术相关研究现状及趋势的文献可视化分析. 中国胸心血管外科临床杂志, 2022, 29(12): 1594-1600.Zhang SY, Lin M, Wang H, et al. Bibliometrics and visualization analysis of esophageal cancer surgery-related researches. Chin J Clin Thorac Cardiovasc Surg, 2022, 29(12): 1594-1600.
9.	高华, 赵晔, 冯海明, 等. 基于文献计量学方法分析我国肺癌合并慢性阻塞性肺疾病的研究现状. 中国胸心血管外科临床杂志, 2019, 26(3): 233-244.Gao Hua, Zhao Ye, Feng Haiming, et al. Current state of lung cancer with chronic obstructive pulmonary disease in China: A bibliometrics analysis. Chin J Clin Thorac Cardiovasc Surg, 2019, 26(3): 233-244.
10.	杨文静, 吕章艳, 冯小双, 等. 人工智能在癌症研究领域的文献可视化分析. 肿瘤防治研究, 2021, 48(2): 133-139.Yang Wenjing Lvzhangyan Feng Xiaoshuang, et al. Visualization Analysis of Literatures About Artificial Intelligence in Cancer Research. Cancer Res Prev Treat, 2021, 48(2): 133-139.
11.	Sebastian Y, Chen C. The boundary-spanning mechanisms of Nobel Prize winning papers. PLoS One, 2021, 16(8): e0254744.
12.	van Eck NJ, Waltman L. Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics, 2010, 84(2): 523-538.
13.	Ma D, Guan B, Song L, et al. A bibliometric analysis of exosomes in cardiovascular diseases from 2001 to 2021. Front Cardiovasc Med, 2021, 8: 734514.
14.	Shi Y, Wei W, Li L, et al. The global status of research in breast cancer liver metastasis: A bibliometric and visualized analysis. Bioengineered, 2021, 12(2): 12246-12262.
15.	Pan Y, Deng X, Zhuang Y, et al. Research trends around exercise rehabilitation among cancer patients: A bibliometrics and visualized knowledge graph analysis. Biomed Res Int, 2022, 2022: 3755460.
16.	Wang X, Li D, Huang X, et al. A bibliometric analysis and visualization of photothermal therapy on cancer. Transl Cancer Res, 2021, 10(3): 1204-1215.
17.	Zhang NN, Shen X, Liu K, et al. Polymer-tethered nanoparticles: From surface engineering to directional self-assembly. Acc Chem Res, 2022, 55(11): 1503-1513.
18.	Koroleva M, Portnaya I, Mischenko E, et al. Solid lipid nanoparticles and nanoemulsions with solid shell: Physical and thermal stability. J Colloid Interface Sci, 2022, 610: 61-69.
19.	Qi Y, Yu Z, Hu K, et al. Rigid metal/liquid metal nanoparticles: Synthesis and application for locally ablative therapy. Nanomedicine, 2022, 42: 102535.
20.	Shoji S, Miura S, Watanabe S, et al. PhaseⅡstudy of nanoparticle albumin-bound paclitaxel monotherapy for relapsed non-small cell lung cancer with patient-reported outcomes (NLCTG1302). Transl Lung Cancer Res, 2022, 11(7): 1359-1368.
21.	Ninkov A, Frank JR, Maggio LA. Bibliometrics: Methods for studying academic publishing. Perspect Med Educ, 2022, 11(3): 173-176.
22.	Ettinger DS, Wood DE, Aisner DL, et al. Non-small cell lung cancer, version 3. 2022, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw, 2022, 20(5): 497-530.
23.	Chen P, Liu Y, Wen Y, et al. Non-small cell lung cancer in China. Cancer Commun (Lond), 2022, 42(10): 937-970.
24.	Ren Y, Yan Y, Qi H. Photothermal conversion and transfer in photothermal therapy: From macroscale to nanoscale. Adv Colloid Interface Sci, 2022, 308: 102753.
25.	Hwang E, Jung HS. Organelle-targeted photothermal agents for cancer therapy. Chem Commun (Camb), 2021, 57(63): 7731-7742.
26.	Kumar AVP, Dubey SK, Tiwari S, et al. Recent advances in nanoparticles mediated photothermal therapy induced tumor regression. Int J Pharm, 2021, 606: 120848.
27.	Zhao L, Zhang X, Wang X, et al. Recent advances in selective photothermal therapy of tumor. J Nanobiotechnology, 2021, 19(1): 335.
28.	Bloise N, Strada S, Dacarro G, et al. Gold nanoparticles contact with cancer cell: A brief update. Int J Mol Sci, 2022, 23(14): 7683.
29.	Gupta N, Malviya R. Understanding and advancement in gold nanoparticle targeted photothermal therapy of cancer. Biochim Biophys Acta Rev Cancer, 2021, 1875(2): 188532.
30.	Camacho SA, Kobal MB, Moreira LG, et al. The efficiency of photothermal action of gold shell-isolated nanoparticles against tumor cells depends on membrane interactions. Colloids Surf B Biointerfaces, 2022, 211: 112301.
31.	Li X, Lovell JF, Yoon J, et al. Clinical development and potential of photothermal and photodynamic therapies for cancer. Nat Rev Clin Oncol, 2020, 17(11): 657-674.
32.	Feltrin FDS, Agner T, Sayer C, et al. Curcumin encapsulation in functional PLGA nanoparticles: A promising strategy for cancer therapies. Adv Colloid Interface Sci, 2022, 300: 102582.
33.	Feng X, Xiong X, Ma S. Docetaxel-loaded novel nano-platform for synergistic therapy of non-small cell lung cancer. Front Pharmacol, 2022, 13: 832725.

1. Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2024, 74(3): 229-263.
2. Herbst RS, Morgensztern D, Boshoff C. The biology and management of non-small cell lung cancer. Nature, 2018, 553(7689): 446-454.
3. Thai AA, Solomon BJ, Sequist LV, et al. Lung cancer. Lancet, 2021, 398(10299): 535-554.
4. Ruiz-Cordero R, Devine WP. Targeted therapy and checkpoint immunotherapy in lung cancer. Surg Pathol Clin, 2020, 13(1): 17-33.
5. Li S, Xu S, Liang X, et al. Nanotechnology: Breaking the current treatment limits of lung cancer. Adv Healthc Mater, 2021, 10(12): e2100078.
6. Pi C, Zhao W, Zeng M, et al. Anti-lung cancer effect of paclitaxel solid lipid nanoparticles delivery system with curcumin as co-loading partner in vitro and in vivo. Drug Deliv, 2022, 29(1): 1878-1891.
7. Sun Y, Yang J, Li Y, et al. Single low-dose INC280-loaded theranostic nanoparticles achieve multirooted delivery for MET-targeted primary and liver metastatic NSCLC. Mol Cancer, 2022, 21(1): 212.
8. 张绍元, 林淼, 汪灏, 等. 食管癌手术相关研究现状及趋势的文献可视化分析. 中国胸心血管外科临床杂志, 2022, 29(12): 1594-1600.Zhang SY, Lin M, Wang H, et al. Bibliometrics and visualization analysis of esophageal cancer surgery-related researches. Chin J Clin Thorac Cardiovasc Surg, 2022, 29(12): 1594-1600.
9. 高华, 赵晔, 冯海明, 等. 基于文献计量学方法分析我国肺癌合并慢性阻塞性肺疾病的研究现状. 中国胸心血管外科临床杂志, 2019, 26(3): 233-244.Gao Hua, Zhao Ye, Feng Haiming, et al. Current state of lung cancer with chronic obstructive pulmonary disease in China: A bibliometrics analysis. Chin J Clin Thorac Cardiovasc Surg, 2019, 26(3): 233-244.
10. 杨文静, 吕章艳, 冯小双, 等. 人工智能在癌症研究领域的文献可视化分析. 肿瘤防治研究, 2021, 48(2): 133-139.Yang Wenjing Lvzhangyan Feng Xiaoshuang, et al. Visualization Analysis of Literatures About Artificial Intelligence in Cancer Research. Cancer Res Prev Treat, 2021, 48(2): 133-139.
11. Sebastian Y, Chen C. The boundary-spanning mechanisms of Nobel Prize winning papers. PLoS One, 2021, 16(8): e0254744.
12. van Eck NJ, Waltman L. Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics, 2010, 84(2): 523-538.
13. Ma D, Guan B, Song L, et al. A bibliometric analysis of exosomes in cardiovascular diseases from 2001 to 2021. Front Cardiovasc Med, 2021, 8: 734514.
14. Shi Y, Wei W, Li L, et al. The global status of research in breast cancer liver metastasis: A bibliometric and visualized analysis. Bioengineered, 2021, 12(2): 12246-12262.
15. Pan Y, Deng X, Zhuang Y, et al. Research trends around exercise rehabilitation among cancer patients: A bibliometrics and visualized knowledge graph analysis. Biomed Res Int, 2022, 2022: 3755460.
16. Wang X, Li D, Huang X, et al. A bibliometric analysis and visualization of photothermal therapy on cancer. Transl Cancer Res, 2021, 10(3): 1204-1215.
17. Zhang NN, Shen X, Liu K, et al. Polymer-tethered nanoparticles: From surface engineering to directional self-assembly. Acc Chem Res, 2022, 55(11): 1503-1513.
18. Koroleva M, Portnaya I, Mischenko E, et al. Solid lipid nanoparticles and nanoemulsions with solid shell: Physical and thermal stability. J Colloid Interface Sci, 2022, 610: 61-69.
19. Qi Y, Yu Z, Hu K, et al. Rigid metal/liquid metal nanoparticles: Synthesis and application for locally ablative therapy. Nanomedicine, 2022, 42: 102535.
20. Shoji S, Miura S, Watanabe S, et al. PhaseⅡstudy of nanoparticle albumin-bound paclitaxel monotherapy for relapsed non-small cell lung cancer with patient-reported outcomes (NLCTG1302). Transl Lung Cancer Res, 2022, 11(7): 1359-1368.
21. Ninkov A, Frank JR, Maggio LA. Bibliometrics: Methods for studying academic publishing. Perspect Med Educ, 2022, 11(3): 173-176.
22. Ettinger DS, Wood DE, Aisner DL, et al. Non-small cell lung cancer, version 3. 2022, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw, 2022, 20(5): 497-530.
23. Chen P, Liu Y, Wen Y, et al. Non-small cell lung cancer in China. Cancer Commun (Lond), 2022, 42(10): 937-970.
24. Ren Y, Yan Y, Qi H. Photothermal conversion and transfer in photothermal therapy: From macroscale to nanoscale. Adv Colloid Interface Sci, 2022, 308: 102753.
25. Hwang E, Jung HS. Organelle-targeted photothermal agents for cancer therapy. Chem Commun (Camb), 2021, 57(63): 7731-7742.
26. Kumar AVP, Dubey SK, Tiwari S, et al. Recent advances in nanoparticles mediated photothermal therapy induced tumor regression. Int J Pharm, 2021, 606: 120848.
27. Zhao L, Zhang X, Wang X, et al. Recent advances in selective photothermal therapy of tumor. J Nanobiotechnology, 2021, 19(1): 335.
28. Bloise N, Strada S, Dacarro G, et al. Gold nanoparticles contact with cancer cell: A brief update. Int J Mol Sci, 2022, 23(14): 7683.
29. Gupta N, Malviya R. Understanding and advancement in gold nanoparticle targeted photothermal therapy of cancer. Biochim Biophys Acta Rev Cancer, 2021, 1875(2): 188532.
30. Camacho SA, Kobal MB, Moreira LG, et al. The efficiency of photothermal action of gold shell-isolated nanoparticles against tumor cells depends on membrane interactions. Colloids Surf B Biointerfaces, 2022, 211: 112301.
31. Li X, Lovell JF, Yoon J, et al. Clinical development and potential of photothermal and photodynamic therapies for cancer. Nat Rev Clin Oncol, 2020, 17(11): 657-674.
32. Feltrin FDS, Agner T, Sayer C, et al. Curcumin encapsulation in functional PLGA nanoparticles: A promising strategy for cancer therapies. Adv Colloid Interface Sci, 2022, 300: 102582.
33. Feng X, Xiong X, Ma S. Docetaxel-loaded novel nano-platform for synergistic therapy of non-small cell lung cancer. Front Pharmacol, 2022, 13: 832725.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

A bibliometric analysis of nanoparticles in the treatment of non-small cell lung cancer

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