抗接触蛋白相关蛋白 2/Hu 抗体双阳性莫旺综合征一例_West China Medical Journal

Authors：

滕思思 ¹ , 周静宇 ² ,  张舒婷 ²

1. ;
2. ;

Corresponding author：

张舒婷, Email: shutingzhang@scu.edu.cn

Keywords：

莫旺综合征; 抗接触蛋白相关蛋白 2 抗体; 抗 Hu 抗体

DOI：

10.7507/1002-0179.202504246

Video：

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Abstract Full text Figures/Tables Video References Cited by

1.	Masrori P, Vaesen Bentein H, Raskin J, et al. Caspr2 autoantibody-associated Morvan syndrome predating thymoma relapse by 30 months. Lung Cancer, 2021, 153: 117-119.
2.	Abou-Zeid E, Boursoulian LJ, Metzer WS, et al. Morvan syndrome: a case report and review of the literature. J Clin Neuromuscul Dis, 2012, 13(4): 214-227.
3.	Vale TC, Pedroso JL, Dutra LA, et al. Morvan syndrome as a paraneoplastic disorder of thymoma with anti-CASPR2 antibodies. Lancet, 2017, 389(10076): 1367-1368.
4.	Irani SR, Alexander S, Waters P, et al. Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan’s syndrome and acquired neuromyotonia. Brain, 2010, 133(9): 2734-2748.
5.	Irani SR, Pettingill P, Kleopa KA, et al. Morvan syndrome: clinical and serological observations in 29 cases. Ann Neurol, 2012, 72(2): 241-255.
6.	Walusinski O, Honnorat J. Augustin Morvan (1819-1897), a little-known rural physician and neurologist. Rev Neurol (Paris), 2013, 169(1): 2-8.
7.	Lee EK, Maselli RA, Ellis WG, et al. Morvan’s fibrillary chorea: a paraneoplastic manifestation of thymoma. J Neurol Neurosurg Psychiatry, 1998, 65(6): 857-862.
8.	Winger DI, Spiegler P, Trow TK, et al. Radiology-Pathology Conference: pulmonary hyalinizing granuloma associated with lupus-like anticoagulant and Morvan’s syndrome. Clin Imaging, 2007, 31(4): 264-268.
9.	Madrid A, Gil-Peralta A, Gil-Néciga E, et al. Morvan’s fibrillary chorea: remission after plasmapheresis. J Neurol, 1996, 243(4): 350-353.
10.	Ma D, Xiang Q, Mo Z, et al. A case series: Three cases of Morvan’s syndrome as a rare autoimmune disorder with anti-Caspr2 antibody. Medicine (Baltimore), 2024, 103(42): e40159.
11.	Masood W, Lui F, Sitammagari KK. Morvan syndrome//StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025.
12.	曾艳平, 解燕春, 罗瑛, 等. 莫旺综合征 2 例报道及文献复习. 神经损伤与功能重建, 2025, 20(3): 183-186.
13.	Barber PA, Anderson NE, Vincent A. Morvan’s syndrome associated with voltage-gated K⁺ channel antibodies. Neurology, 2000, 54(3): 771-772.
14.	Graus F, Cordon-Cardo C, Posner JB. Neuronal antinuclear antibody in sensory neuronopathy from lung cancer. Neurology, 1985, 35(4): 538-543.
15.	Villagrán-García M, Farina A, Muñiz-Castrillo S, et al. Revisiting anti-Hu paraneoplastic autoimmunity: phenotypic characterization and cancer diagnosis. Brain Commun, 2023, 5(5): fcad247.
16.	Maskery M, Chhetri SK, Dayanandan R, et al. Morvan syndrome: a case report with patient narrative and video. Neurohospitalist, 2016, 6(1): 32-35.
17.	Kannoth S. Paraneoplastic neurologic syndrome: a practical approach. Ann Indian Acad Neurol, 2012, 15(1): 6-12.

1. Masrori P, Vaesen Bentein H, Raskin J, et al. Caspr2 autoantibody-associated Morvan syndrome predating thymoma relapse by 30 months. Lung Cancer, 2021, 153: 117-119.
2. Abou-Zeid E, Boursoulian LJ, Metzer WS, et al. Morvan syndrome: a case report and review of the literature. J Clin Neuromuscul Dis, 2012, 13(4): 214-227.
3. Vale TC, Pedroso JL, Dutra LA, et al. Morvan syndrome as a paraneoplastic disorder of thymoma with anti-CASPR2 antibodies. Lancet, 2017, 389(10076): 1367-1368.
4. Irani SR, Alexander S, Waters P, et al. Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan’s syndrome and acquired neuromyotonia. Brain, 2010, 133(9): 2734-2748.
5. Irani SR, Pettingill P, Kleopa KA, et al. Morvan syndrome: clinical and serological observations in 29 cases. Ann Neurol, 2012, 72(2): 241-255.
6. Walusinski O, Honnorat J. Augustin Morvan (1819-1897), a little-known rural physician and neurologist. Rev Neurol (Paris), 2013, 169(1): 2-8.
7. Lee EK, Maselli RA, Ellis WG, et al. Morvan’s fibrillary chorea: a paraneoplastic manifestation of thymoma. J Neurol Neurosurg Psychiatry, 1998, 65(6): 857-862.
8. Winger DI, Spiegler P, Trow TK, et al. Radiology-Pathology Conference: pulmonary hyalinizing granuloma associated with lupus-like anticoagulant and Morvan’s syndrome. Clin Imaging, 2007, 31(4): 264-268.
9. Madrid A, Gil-Peralta A, Gil-Néciga E, et al. Morvan’s fibrillary chorea: remission after plasmapheresis. J Neurol, 1996, 243(4): 350-353.
10. Ma D, Xiang Q, Mo Z, et al. A case series: Three cases of Morvan’s syndrome as a rare autoimmune disorder with anti-Caspr2 antibody. Medicine (Baltimore), 2024, 103(42): e40159.
11. Masood W, Lui F, Sitammagari KK. Morvan syndrome//StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025.
12. 曾艳平, 解燕春, 罗瑛, 等. 莫旺综合征 2 例报道及文献复习. 神经损伤与功能重建, 2025, 20(3): 183-186.
13. Barber PA, Anderson NE, Vincent A. Morvan’s syndrome associated with voltage-gated K⁺ channel antibodies. Neurology, 2000, 54(3): 771-772.
14. Graus F, Cordon-Cardo C, Posner JB. Neuronal antinuclear antibody in sensory neuronopathy from lung cancer. Neurology, 1985, 35(4): 538-543.
15. Villagrán-García M, Farina A, Muñiz-Castrillo S, et al. Revisiting anti-Hu paraneoplastic autoimmunity: phenotypic characterization and cancer diagnosis. Brain Commun, 2023, 5(5): fcad247.
16. Maskery M, Chhetri SK, Dayanandan R, et al. Morvan syndrome: a case report with patient narrative and video. Neurohospitalist, 2016, 6(1): 32-35.
17. Kannoth S. Paraneoplastic neurologic syndrome: a practical approach. Ann Indian Acad Neurol, 2012, 15(1): 6-12.

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