Research progress of diabetic vitreopapillary traction syndrome_Chinese Journal of Ocular Fundus Diseases

Authors：

Wang Yayun , Yu Yi , Tian Mo , Li Bingyu , Sun Xinran ,  Yu Xuhui

Eye Hospital, The First Affiliated Hospital of Harbin Medical University, Harbin 150000, China;

Corresponding author：

Yu Xuhui, Email: yu_xuhui@163.com

Keywords：

Vitreopapillary traction syndrome; Diabetes mellitus; Anomalous posterior vitreous detachment; Review

DOI：

10.3760/cma.j.cn511434-20250625-00283

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Diabetic vitreopapillary traction syndrome (DVPT) is an important complication of diabetic eye disease, caused by persistent mechanical traction exerted by the vitreous on the optic disc and its surrounding tissues, It can lead to severe consequences such as visual impairment and visual field defects. The core mechanisms involve diabetic vitreous remodeling (including hyperglycemia-induced vitreous liquefaction, abnormal cross-linking, and anomalous posterior vitreous detachment) and the fibrovascular proliferation-traction vicious cycle, both contributing to the initiation and progression. Regarding diagnosis, optical coherence tomography is the cornerstone for visualizing vitreo-papillary anatomical relationships. B-scan ultrasonography is valuable in cases with opaque media. Visual field testing assesses the extent of retinal nerve fiber layer involvement. Fluorescein fundus angiography reveals disruption of the blood-retinal barrier on the optic disc surface. Optical coherence tomography angiography shows promise as a novel tool for early diagnosis and dynamic monitoring by quantifying microvascular abnormalities in the optic disc region. For treatment, conservative observation is suitable for patients with mild symptoms and stable visual function. For those experiencing progressive visual impairment, significant disc edema, or concurrent complications of diabetic retinopathy requiring intervention, active consideration of pars plana vitrectomy is warranted. Future research can focus on neuroprotection and revasrearization strategies, the quantitative relationship between traction intensity and optic nerve injury, and the optimization of individualized treatment strategies based on mechanisms, thereby further improving the diagnosis and treatment level of DVPT.

1.	Babaeva DB, Shishkin MM, Fayzrakhmanov RR. Biomechanics of diabetic vitreopapillary traction syndrome[J]. Vestn Oftalmol, 2024, 140(2): 78-82. DOI: 10.17116/oftalma202414002178.
2.	Gabriel RS, Boisvert CJ, Mehta MC. Review of vitreopapillary traction syndrome[J]. Neuroophthalmology, 2020, 44(4): 213-218. DOI: 10.1080/01658107.2020.1725063.
3.	Rumelt S, Karatas M, Pikkel J, et al. Optic disc traction syndrome associated with central retinal vein occlusion[J]. Arch Ophthalmol, 2003, 121(8): 1093-1097. DOI: 10.1001/archopht.121.8.1093.
4.	Wang MY, Nguyen D, Hindoyan N, et al. Vitreo-papillary adhesion in macular hole and macular pucker[J]. Retina, 2009, 29(5): 644-650. DOI: 10.1097/IAE.0b013e31819e0d92.
5.	de Bustros S, Thompson JT, Michels RG, et al. Vitrectomy for progressive proliferative diabetic retinopathy[J]. Arch Ophthalmol, 1987, 105(2): 196-199. DOI: 10.1001/archopht.1987.01060020050026.
6.	Kroll P, Wiegand W, Schmidt J. Vitreopapillary traction in proliferative diabetic vitreoretinopathy[J]. Br J Ophthalmol, 1999, 83(2): 261-264. DOI: 10.1136/bjo.83.3.261.
7.	Karatas M, Ramirez JA, Ophir A. Diabetic vitreopapillary traction and macular oedema[J]. Eye (Lond), 2005, 19(6): 676-682. DOI: 10.1038/sj.eye.6701622.
8.	Babayeva DB, Shishkin MM, Fayzrakhmanov RR, et al. Vitreopapillary traction syndrome in patients with proliferative diabetic retinopathy[J]. Vestn Oftalmol, 2021, 137(6): 38-44. DOI: 10.17116/oftalma202113706138.
9.	Sebag J. Anatomy and pathology of the vitreo-retinal interface[J]. Eye (Lond), 1992, 6(Pt 6): 541-552. DOI: 10.1038/eye.1992.119.
10.	Foos RY, Roth AM. Surface structure of the optic nerve head. 2. Vitreopapillary attachments and posterior vitreous detachment[J]. Am J Ophthalmol, 1973, 76(5): 662-671. DOI: 10.1016/0002-9394(73)90560-6.
11.	Foos RY. Vitreoretinal juncture over retinal vessels[J]. Albrecht Von Graefes Arch Klin Exp Ophthalmol, 1977, 204(4): 223-234. DOI: 10.1007/BF00415316.
12.	Anderson DR. Ultrastructure of the optic nerve head[J]. Arch Ophthalmol, 1970, 83(1): 63-73. DOI: 10.1001/archopht.1970.00990030065013.
13.	Arnold AC. Vascular supply of the optic nerve head: implications for optic disc ischaemia[J]. Br J Ophthalmol, 2023, 107(5): 595-599. DOI: 10.1136/bjo-2022-322254.
14.	Hiscott P, Waller HA, Grierson I, et al. The extracellular matrix of reparative tissue in the vitreous: fibronectin production in proliferative diabetic retinopathy membranes[J]. Eye (Lond), 1993, 7(Pt 2): 288-292. DOI: 10.1038/eye.1993.62.
15.	Shibahara T, Ago T, Nakamura K, et al. PDGFR β-positive cell-mediated post-stroke remodeling of fibronectin and laminin α2 for tissue repair and functional recovery[J]. J Cereb Blood Flow Metab, 2023, 43(4): 518-530. DOI: 10.1177/0271678X221145092.
16.	Karve IP, Taylor JM, Crack PJ. The contribution of astrocytes and microglia to traumatic brain injury[J]. Br J Pharmacol, 2016, 173(4): 692-702. DOI: 10.1111/bph.13125.
17.	Zhao JP, Ma ZZ, Chen S, et al. Optic nerve lesions in diabetic rats: blood flow to the optic nerve, permeability of micro blood vessels and histopathology[J]. Int J Ophthalmol, 2010, 3(4): 291-294. DOI: 10.3980/j.issn.2222-3959.2010.04.03.
18.	黄厚斌. 玻璃体间隙及临床应用[J]. 眼科, 2023, 32(3): 177-181. DOI: 10.13281/j.cnki.issn.1004-4469.2023.03.001.Huang HB. Vitreous space and its clinical applications[J]. Ophthalmol CHN, 2023, 32(3): 177-181. DOI: 10.13281/j.cnki.issn.1004-4469.2023.03.001.
19.	龚轶, 邵彦, 李筱荣. 糖尿病玻璃体性状特点及其与增殖性糖尿病视网膜病变的关系[J]. 国际眼科杂志, 2023, 23(9): 1482-1485. DOI: 10.3980/j.issn.1672-5123.2023.9.11.Gong Y, Shao Y, Li XR. Vitreous properties in patients with diabetes mellitus and its relationship with proliferative diabetic retinopathy[J]. Int Eye Sci, 2023, 23(9): 1482-1485. DOI: 10.3980/j.issn.1672-5123.2023.9.11.
20.	Kang SW, Hyung SM, Choi MY, et al. Induction of vitreolysis and vitreous detachment with hyaluronidase and perfluoropropane gas[J]. Korean J Ophthalmol, 1995, 9(2): 69-78. DOI: 10.3341/kjo.1995.9.2.69.
21.	Johnson MW. Posterior vitreous detachment: evolution and complications of its early stAGE[J]. Am J Ophthalmol, 2010, 149(3): 371-382. DOI: 10.1016/j.ajo.2009.11.022.
22.	Hixson A, Reynolds S. Peripapillary vitreoretinal traction[J]. Optometry, 2011, 82(10): 602-606. DOI: 10.1016/j.optm.2011.02.018.
23.	Hedges TR 3rd, Flattem NL, Bagga A. Vitreopapillary traction confirmed by optical coherence tomography[J]. Arch Ophthalmol, 2006, 124(2): 279-281. DOI: 10.1001/archopht.124.2.279.
24.	Sebag J, Wang MY, Nguyen D, et al. Vitreopapillary adhesion in macular diseases[J]. Trans Am Ophthalmol Soc, 2009, 107: 35-44.
25.	Sebag J. Anomalous posterior vitreous detachment: a unifying concept in vitreo-retinal disease[J]. Graefe's Arch Clin Exp Ophthalmol, 2004, 242(8): 690-698. DOI: 10.1007/s00417-004-0980-1.
26.	翁乃清, 魏文斌, 朱晓清, 等. 玻璃体积血的形态结构与玻璃体后脱离的图像特征[J]. 中华眼科杂志, 2001, 37(6): 425-427. DOI: 10.3760/j:issn:0412-4081.2001.06.007.Weng NQ, Wei WB, Zhu XQ, et al. The morphologic structure of vitreous hemorrhage and posterior vitreous detachment[J]. Chin J Ophthalmol, 2001, 37(6): 425-427. DOI: 10.3760/j:issn:0412-4081.2001.06.007.
27.	魏文斌, 何守志, 翁乃清, 等. 玻璃体积血与玻璃体劈裂[J]. 眼科学报, 2003, 19(4): 215-217. DOI: 10.3969/j.issn.1000-4432.2003.04.005.Wei WB, He SZ, Weng NQ, et al. Vitreous hemorrhage and vitreoschisis[J]. Eye Science, 2003, 19(4): 215-217. DOI: 10.3969/j.issn.1000-4432.2003.04.005.
28.	Bejarano E, Taylor A. Too sweet: problems of protein glycation in the eye[J]. Exp Eye Res, 2019, 178: 255-262. DOI: 10.1016/j.exer.2018.08.017.
29.	Katsumura C, Sugiyama T, Nakamura K, et al. Effects of advanced glycation end products on hyaluronan photolysis: a new mechanism of diabetic vitreopathy[J]. Ophthalmic Res, 2004, 36(6): 327-331. DOI: 10.1159/000081635.
30.	van Deemter M, A Bank R, Vehof J, et al. Factors associated with pentosidine accumulation in the human vitreous[J]. Retina, 2017, 37(4): 770-777. DOI: 10.1097/IAE.0000000000001219.
31.	Sebag J. Vitreoschisis[J]. Graefe's Arch Clin Exp Ophthalmol, 2008, 246(3): 329-332. DOI: 10.1007/s00417-007-0743-x.
32.	Stitt AW, Moore JE, Sharkey JA, et al. Advanced glycation end products in vitreous: structural and functional implications for diabetic vitreopathy[J]. Invest Ophthalmol Vis Sci, 1998, 39(13): 2517-2523.
33.	Dubey AK, Nagpal PN, Chawla S, et al. A proposed new classification for diabetic retinopathy: the concept of primary and secondary vitreopathy[J]. Indian J Ophthalmol, 2008, 56(1): 23-29. DOI: 10.4103/0301-4738.37592.
34.	Chu TG, Lopez PF, Cano MR, et al. Posterior vitreoschisis. An echographic finding in proliferative diabetic retinopathy[J]. Ophthalmology, 1996, 103(2): 315-322. DOI: 10.1016/s0161-6420(96)30698-2.
35.	Schwatz SD, Alexander R, Hiscott P, et al. Recognition of vitreoschisis in proliferative diabetic retinopathy. A useful landmark in vitrectomy for diabetic traction retinal detachment[J]. Ophthalmology, 1996, 103(2): 323-328. DOI: 10.1016/s0161-6420(96)30697-0.
36.	Romano MR, Allegrini D, Della Guardia C, et al. Vitreous and intraretinal macular changes in diabetic macular edema with and without tractional components[J]. Graefe's Arch Clin Exp Ophthalmol, 2019, 257(1): 1-8. DOI: 10.1007/s00417-018-4173-8.
37.	Provenzano PP, Keely PJ. Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling[J]. J Cell Sci, 2011, 124(Pt 8): 1195-1205. DOI: 10.1242/jcs.067009.
38.	Katz B, Hoyt WF. Intrapapillary and peripapillary hemorrhage in young patients with incomplete posterior vitreous detachment. Signs of vitreopapillary traction[J]. Ophthalmology, 1995, 102(2): 349-354. DOI: 10.1016/s0161-6420(95)31018-4.
39.	Parsa CF, Hoyt WF. Nonarteritic anterior ischemic optic neuropathy (NAION): a misnomer. Rearranging pieces of a puzzle to reveal a nonischemic papillopathy caused by vitreous separation[J]. Ophthalmology, 2015, 122(3): 439-442. DOI: 10.1016/j.ophtha.2014.11.011.
40.	Fong JW, Sallam AB, Chacko JG. Vitreopapillary traction masquerading as papillitis and papilledema[J/OL]. J Neuroophthalmol, 2021, 41(4): e711-e712[2021-12-01]. https://pubmed.ncbi.nlm.nih.gov/33417415/. DOI: 10.1097/WNO.0000000000001159.
41.	Weng CY, Khimani KS, Foroozan R, et al. A sticky situation[J]. Surv Ophthalmol, 2018, 63(5): 736-744. DOI: 10.1016/j.survophthal.2018.04.004.
42.	Katz B, Hoyt WF. Gaze-evoked amaurosis from vitreopapillary traction[J]. Am J Ophthalmol, 2005, 139(4): 631-637. DOI: 10.1016/j.ajo.2004.10.045.
43.	Chan JW, Liu H, Ma EL, et al. Peripapillary vitreous traction syndrome: expanding the spectrum of anterior optic neuropathies[J]. J Neuroophthalmol, 2023, 43(4): 514-519. DOI: 10.1097/WNO.0000000000001874.
44.	Houle E, Miller NR. Bilateral vitreopapillary traction demonstrated by optical coherence tomography mistaken for papilledema[J/OL]. Case Rep Ophthalmol, 2012, 2012: 682659[2012-10-04]. https://pubmed.ncbi.nlm.nih.gov/23091763/. DOI: 10.1155/2012/682659.
45.	Romano MR, Comune C, Ferrara M, et al. Retinal changes induced by epiretinal tangential forces[J/OL]. J Ophthalmol, 2015, 2015: 372564[2015-09-03]. https://pubmed.ncbi.nlm.nih.gov/26421183/. DOI: 10.1155/2015/372564.
46.	Wong A, Kokolakis P, Rodriguez A, et al. The role of optical coherence tomography raster imaging as a valuable diagnostic tool in the differential between optic disc hemorrhage and vitreopapillary traction[J]. Mil Med, 2012, 177(11): 1374-1381. DOI: 10.7205/milmed-d-12-00148.
47.	何娜, 廖丁莹, 郑玉萍, 等. 糖尿病性黄斑水肿与玻璃体视乳头牵引的相关性分析[J]. 西部医学, 2016, 28(10): 1393-1396. DOI: 10.3969/j.issn.1672-3511.2016.10.014.He N, Liao DY, Zheng YP, et al. Correlation analysis between diabetic macular edema and vitreopapillary traction[J]. Med J West China, 2016, 28(10): 1393-1396. DOI: 10.3969/j.issn.1672-3511.2016.10.014.
48.	Kim YW, Jeoung JW, Yu HG. Vitreopapillary traction in eyes with idiopathic epiretinal membrane: a spectral-domain optical coherence tomography study[J]. Ophthalmology, 2014, 121(10): 1976-1982. DOI: 10.1016/j.ophtha.2014.04.011.
49.	Simonett JM, Winges KM. Vitreopapillary traction detected by optical coherence tomography[J/OL]. JAMA Ophthalmol, 2018, 136(5): e180727[2018-05-10]. https://pubmed.ncbi.nlm.nih.gov/29800255/. DOI: 10.1001/jamaophthalmol.2018.0727.
50.	Cabrera S, Katz A, Margalit E. Vitreopapillary traction: cost-effective diagnosis by optical coherence tomography[J]. Can J Ophthalmol, 2006, 41(6): 763-765. DOI: 10.3129/i06-073.
51.	Chang LK, Fine HF, Spaide RF, et al. Ultrastructural correlation of spectral-domain optical coherence tomographic findings in vitreomacular traction syndrome[J]. Am J Ophthalmol, 2008, 146(1): 121-127. DOI: 10.1016/j.ajo.2008.03.001.
52.	Mehta A, Park SC, Liebmann JM, et al. Arcuate scotoma associated with traction at the optic disc[J]. Eye (Lond), 2013, 27(4): 572-574. DOI: 10.1038/eye.2013.21.
53.	KOÇ F, Kahrman HG, Orduyilmaz. Vitreopapillary Tractions[J]. Current Retina, 2018: 244-248. DOI: 10.37783/crj-0100.
54.	Spaide RF, Fujimoto JG, Waheed NK. Optical coherence tomography angiography[J]. Prog Retin Eye Res, 2018, 64: 1-55. DOI: 10.1016/j.preteyeres.2017.11.003.
55.	Hagag AM, Huang D. Optical coherence tomography angiography in neuro-ophthalmology[J]. J Neuroophthalmol, 2017, 37(4): 355-357. DOI: 10.1097/WNO.0000000000000584.
56.	Douglas VP, Douglas KAA, Torun N. Optical coherence tomography angiography in neuro-ophthalmology[J]. Curr Opin Ophthalmol, 2023, 34(4): 354-360. DOI: 10.1097/ICU.0000000000000955.
57.	Waheed NK, Rosen RB, Jia Y, et al. Optical coherence tomography angiography in diabetic retinopathy[J/OL]. Prog Retin Eye Res, 2023, 97: 101206[2023-07-26]. https://pubmed.ncbi.nlm.nih.gov/37499857/. DOI: 10.1016/j.preteyeres.2023.101206.
58.	Modarres M, Sanjari MS, Falavarjani KG. Vitrectomy and release of presumed epipapillary vitreous traction for treatment of nonarteritic anterior ischemic optic neuropathy associated with partial posterior vitreous detachment[J]. Ophthalmology, 2007, 114(2): 340-344. DOI: 10.1016/j.ophtha.2006.07.063.
59.	Thompson AC, Bhatti MT, Gospe SM 3rd. Spectral-domain optical coherence tomography of the vitreopapillary interface in acute nonarteritic anterior ischemic optic neuropathy[J]. Am J Ophthalmol, 2018, 195: 199-208. DOI: 10.1016/j.ajo.2018.08.002.
60.	Hwang YH, Kim YY. Peripapillary retinal nerve fiber layer thickening associated with vitreopapillary traction[J]. Semin Ophthalmol, 2015, 30(2): 136-138. DOI: 10.3109/08820538.2013.833257.
61.	中华医学会眼科学分会神经眼科学组. 中国糖尿病视神经病变诊断和治疗专家共识(2022年)[J]. 中华眼科杂志, 2022, 58(6): 405-411. DOI: 10.3760/cma.j.cn112142-20211221-00593.Neuro-ophthalmology Group of Ophthalmology Branch of Chinese Medical Association. Chinese expert consensus on diagnosis and treatment of diabetic optic neuropathy (2022)[J]. Chin J Ophthalmol, 2022, 58(6): 405-411. DOI: 10.3760/cma.j.cn112142-20211221-00593.
62.	Becker KN, Nichols J. Review of diabetic papillitis[J/OL]. Dis Mon, 2021, 67(5): 101141[2021-02-03]. https://pubmed.ncbi.nlm.nih.gov/33549309/. DOI: 10.1016/j.disamonth.2021.101141.
63.	Saito Y, Ueki N, Hamanaka N, et al. Transient optic disc edema by vitreous traction in a quiescent eye with proliferative diabetic retinopathy mimicking diabetic papillopathy[J]. Retina, 2005, 25(1): 83-84. DOI: 10.1097/00006982-200501000-00013.
64.	Xie JS, Donaldson L, Margolin E. Papilledema: a review of etiology, pathophysiology, diagnosis, and management[J]. Surv Ophthalmol, 2022, 67(4): 1135-1159. DOI: 10.1016/j.survophthal.2021.11.007.
65.	Cunha LP, Costa-Cunha LVF, Costa CF, et al. Ultrastructural changes detected using swept-source optical coherence tomography in severe vitreopapillary traction: a case report[J]. Arq Bras Oftalmol, 2019, 82(6): 517-521. DOI: 10.5935/0004-2749.20190099.
66.	Nomura Y, Tamaki Y, Yanagi Y. Vitreopapillary traction diagnosed by spectral domain optical coherence tomography[J]. Ophthalmic Surg Lasers Imaging, 2010, 41(Suppl): S74-76. DOI: 10.3928/15428877-20101031-16.
67.	Aras C, Arici C, Akova N. Peripapillary serous retinal detachment preceding complete posterior vitreous detachment[J]. Graefe's Arch Clin Exp Ophthalmol, 2008, 246(6): 927-929. DOI: 10.1007/s00417-008-0776-9.
68.	Stefansson E. Physiology of vitreous surgery[J]. Graefe's Arch Clin Exp Ophthalmol, 2009, 247(2): 147-163. DOI: 10.1007/s00417-008-0980-7.
69.	Sebag J. The vitreoretinal interface and its role in the pathogenesis of vitreomaculopathies[J]. Ophtalmol, 2015, 112(1): 10-19. DOI: 10.1007/s00347-014-3048-6.
70.	Romano MR, Vallejo-Garcia JL, Camesasca FI, et al. Vitreo-papillary adhesion as a prognostic factor in pseudo- and lamellar macular holes[J]. Eye (Lond), 2012, 26(6): 810-815. DOI: 10.1038/eye.2012.43.
71.	Bottós J, Elizalde J, Arevalo JF, et al. Vitreomacular traction syndrome[J]. J Ophthalmic Vis Res, 2012, 7(2): 148-161.
72.	Neffendorf JE, Kirthi V, Pringle E. Ocriplasmin for symptomatic vitreomacular adhesion[J/OL]. Cochrane Database Syst Rev, 2017, 10(10): CD011874[2017-10-17]. https://pubmed.ncbi.nlm.nih.gov/29040800/. DOI: 10.1002/14651858.CD011874.pub2.
73.	Cereda MG, Preziosa C, DʼAgostino I, et al. Ocriplasmin for vitreomacular traction: looking outside the macula: a wide-field optical coherence tomography study[J]. Retina, 2018, 38(8): 1541-1548. DOI: 10.1097/IAE.0000000000001785.
74.	NAGEha CK, Rishi P, Rishi E. Vitrectomy for vitreopapillary traction in a nondiabetic 16-year-old girl[J]. Oman J Ophthalmol, 2017, 10(1): 38-39. DOI: 10.4103/0974-620X.200697.
75.	Meyer CH, Schmidt JC, Mennel S, et al. Functional and anatomical results of vitreopapillary traction after vitrectomy[J]. Acta Ophthalmol Scand, 2007, 85(2): 221-222. DOI: 10.1111/j.1600-0420.2006.00792.x.

1. Babaeva DB, Shishkin MM, Fayzrakhmanov RR. Biomechanics of diabetic vitreopapillary traction syndrome[J]. Vestn Oftalmol, 2024, 140(2): 78-82. DOI: 10.17116/oftalma202414002178.
2. Gabriel RS, Boisvert CJ, Mehta MC. Review of vitreopapillary traction syndrome[J]. Neuroophthalmology, 2020, 44(4): 213-218. DOI: 10.1080/01658107.2020.1725063.
3. Rumelt S, Karatas M, Pikkel J, et al. Optic disc traction syndrome associated with central retinal vein occlusion[J]. Arch Ophthalmol, 2003, 121(8): 1093-1097. DOI: 10.1001/archopht.121.8.1093.
4. Wang MY, Nguyen D, Hindoyan N, et al. Vitreo-papillary adhesion in macular hole and macular pucker[J]. Retina, 2009, 29(5): 644-650. DOI: 10.1097/IAE.0b013e31819e0d92.
5. de Bustros S, Thompson JT, Michels RG, et al. Vitrectomy for progressive proliferative diabetic retinopathy[J]. Arch Ophthalmol, 1987, 105(2): 196-199. DOI: 10.1001/archopht.1987.01060020050026.
6. Kroll P, Wiegand W, Schmidt J. Vitreopapillary traction in proliferative diabetic vitreoretinopathy[J]. Br J Ophthalmol, 1999, 83(2): 261-264. DOI: 10.1136/bjo.83.3.261.
7. Karatas M, Ramirez JA, Ophir A. Diabetic vitreopapillary traction and macular oedema[J]. Eye (Lond), 2005, 19(6): 676-682. DOI: 10.1038/sj.eye.6701622.
8. Babayeva DB, Shishkin MM, Fayzrakhmanov RR, et al. Vitreopapillary traction syndrome in patients with proliferative diabetic retinopathy[J]. Vestn Oftalmol, 2021, 137(6): 38-44. DOI: 10.17116/oftalma202113706138.
9. Sebag J. Anatomy and pathology of the vitreo-retinal interface[J]. Eye (Lond), 1992, 6(Pt 6): 541-552. DOI: 10.1038/eye.1992.119.
10. Foos RY, Roth AM. Surface structure of the optic nerve head. 2. Vitreopapillary attachments and posterior vitreous detachment[J]. Am J Ophthalmol, 1973, 76(5): 662-671. DOI: 10.1016/0002-9394(73)90560-6.
11. Foos RY. Vitreoretinal juncture over retinal vessels[J]. Albrecht Von Graefes Arch Klin Exp Ophthalmol, 1977, 204(4): 223-234. DOI: 10.1007/BF00415316.
12. Anderson DR. Ultrastructure of the optic nerve head[J]. Arch Ophthalmol, 1970, 83(1): 63-73. DOI: 10.1001/archopht.1970.00990030065013.
13. Arnold AC. Vascular supply of the optic nerve head: implications for optic disc ischaemia[J]. Br J Ophthalmol, 2023, 107(5): 595-599. DOI: 10.1136/bjo-2022-322254.
14. Hiscott P, Waller HA, Grierson I, et al. The extracellular matrix of reparative tissue in the vitreous: fibronectin production in proliferative diabetic retinopathy membranes[J]. Eye (Lond), 1993, 7(Pt 2): 288-292. DOI: 10.1038/eye.1993.62.
15. Shibahara T, Ago T, Nakamura K, et al. PDGFR β-positive cell-mediated post-stroke remodeling of fibronectin and laminin α2 for tissue repair and functional recovery[J]. J Cereb Blood Flow Metab, 2023, 43(4): 518-530. DOI: 10.1177/0271678X221145092.
16. Karve IP, Taylor JM, Crack PJ. The contribution of astrocytes and microglia to traumatic brain injury[J]. Br J Pharmacol, 2016, 173(4): 692-702. DOI: 10.1111/bph.13125.
17. Zhao JP, Ma ZZ, Chen S, et al. Optic nerve lesions in diabetic rats: blood flow to the optic nerve, permeability of micro blood vessels and histopathology[J]. Int J Ophthalmol, 2010, 3(4): 291-294. DOI: 10.3980/j.issn.2222-3959.2010.04.03.
18. 黄厚斌. 玻璃体间隙及临床应用[J]. 眼科, 2023, 32(3): 177-181. DOI: 10.13281/j.cnki.issn.1004-4469.2023.03.001.Huang HB. Vitreous space and its clinical applications[J]. Ophthalmol CHN, 2023, 32(3): 177-181. DOI: 10.13281/j.cnki.issn.1004-4469.2023.03.001.
19. 龚轶, 邵彦, 李筱荣. 糖尿病玻璃体性状特点及其与增殖性糖尿病视网膜病变的关系[J]. 国际眼科杂志, 2023, 23(9): 1482-1485. DOI: 10.3980/j.issn.1672-5123.2023.9.11.Gong Y, Shao Y, Li XR. Vitreous properties in patients with diabetes mellitus and its relationship with proliferative diabetic retinopathy[J]. Int Eye Sci, 2023, 23(9): 1482-1485. DOI: 10.3980/j.issn.1672-5123.2023.9.11.
20. Kang SW, Hyung SM, Choi MY, et al. Induction of vitreolysis and vitreous detachment with hyaluronidase and perfluoropropane gas[J]. Korean J Ophthalmol, 1995, 9(2): 69-78. DOI: 10.3341/kjo.1995.9.2.69.
21. Johnson MW. Posterior vitreous detachment: evolution and complications of its early stAGE[J]. Am J Ophthalmol, 2010, 149(3): 371-382. DOI: 10.1016/j.ajo.2009.11.022.
22. Hixson A, Reynolds S. Peripapillary vitreoretinal traction[J]. Optometry, 2011, 82(10): 602-606. DOI: 10.1016/j.optm.2011.02.018.
23. Hedges TR 3rd, Flattem NL, Bagga A. Vitreopapillary traction confirmed by optical coherence tomography[J]. Arch Ophthalmol, 2006, 124(2): 279-281. DOI: 10.1001/archopht.124.2.279.
24. Sebag J, Wang MY, Nguyen D, et al. Vitreopapillary adhesion in macular diseases[J]. Trans Am Ophthalmol Soc, 2009, 107: 35-44.
25. Sebag J. Anomalous posterior vitreous detachment: a unifying concept in vitreo-retinal disease[J]. Graefe's Arch Clin Exp Ophthalmol, 2004, 242(8): 690-698. DOI: 10.1007/s00417-004-0980-1.
26. 翁乃清, 魏文斌, 朱晓清, 等. 玻璃体积血的形态结构与玻璃体后脱离的图像特征[J]. 中华眼科杂志, 2001, 37(6): 425-427. DOI: 10.3760/j:issn:0412-4081.2001.06.007.Weng NQ, Wei WB, Zhu XQ, et al. The morphologic structure of vitreous hemorrhage and posterior vitreous detachment[J]. Chin J Ophthalmol, 2001, 37(6): 425-427. DOI: 10.3760/j:issn:0412-4081.2001.06.007.
27. 魏文斌, 何守志, 翁乃清, 等. 玻璃体积血与玻璃体劈裂[J]. 眼科学报, 2003, 19(4): 215-217. DOI: 10.3969/j.issn.1000-4432.2003.04.005.Wei WB, He SZ, Weng NQ, et al. Vitreous hemorrhage and vitreoschisis[J]. Eye Science, 2003, 19(4): 215-217. DOI: 10.3969/j.issn.1000-4432.2003.04.005.
28. Bejarano E, Taylor A. Too sweet: problems of protein glycation in the eye[J]. Exp Eye Res, 2019, 178: 255-262. DOI: 10.1016/j.exer.2018.08.017.
29. Katsumura C, Sugiyama T, Nakamura K, et al. Effects of advanced glycation end products on hyaluronan photolysis: a new mechanism of diabetic vitreopathy[J]. Ophthalmic Res, 2004, 36(6): 327-331. DOI: 10.1159/000081635.
30. van Deemter M, A Bank R, Vehof J, et al. Factors associated with pentosidine accumulation in the human vitreous[J]. Retina, 2017, 37(4): 770-777. DOI: 10.1097/IAE.0000000000001219.
31. Sebag J. Vitreoschisis[J]. Graefe's Arch Clin Exp Ophthalmol, 2008, 246(3): 329-332. DOI: 10.1007/s00417-007-0743-x.
32. Stitt AW, Moore JE, Sharkey JA, et al. Advanced glycation end products in vitreous: structural and functional implications for diabetic vitreopathy[J]. Invest Ophthalmol Vis Sci, 1998, 39(13): 2517-2523.
33. Dubey AK, Nagpal PN, Chawla S, et al. A proposed new classification for diabetic retinopathy: the concept of primary and secondary vitreopathy[J]. Indian J Ophthalmol, 2008, 56(1): 23-29. DOI: 10.4103/0301-4738.37592.
34. Chu TG, Lopez PF, Cano MR, et al. Posterior vitreoschisis. An echographic finding in proliferative diabetic retinopathy[J]. Ophthalmology, 1996, 103(2): 315-322. DOI: 10.1016/s0161-6420(96)30698-2.
35. Schwatz SD, Alexander R, Hiscott P, et al. Recognition of vitreoschisis in proliferative diabetic retinopathy. A useful landmark in vitrectomy for diabetic traction retinal detachment[J]. Ophthalmology, 1996, 103(2): 323-328. DOI: 10.1016/s0161-6420(96)30697-0.
36. Romano MR, Allegrini D, Della Guardia C, et al. Vitreous and intraretinal macular changes in diabetic macular edema with and without tractional components[J]. Graefe's Arch Clin Exp Ophthalmol, 2019, 257(1): 1-8. DOI: 10.1007/s00417-018-4173-8.
37. Provenzano PP, Keely PJ. Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling[J]. J Cell Sci, 2011, 124(Pt 8): 1195-1205. DOI: 10.1242/jcs.067009.
38. Katz B, Hoyt WF. Intrapapillary and peripapillary hemorrhage in young patients with incomplete posterior vitreous detachment. Signs of vitreopapillary traction[J]. Ophthalmology, 1995, 102(2): 349-354. DOI: 10.1016/s0161-6420(95)31018-4.
39. Parsa CF, Hoyt WF. Nonarteritic anterior ischemic optic neuropathy (NAION): a misnomer. Rearranging pieces of a puzzle to reveal a nonischemic papillopathy caused by vitreous separation[J]. Ophthalmology, 2015, 122(3): 439-442. DOI: 10.1016/j.ophtha.2014.11.011.
40. Fong JW, Sallam AB, Chacko JG. Vitreopapillary traction masquerading as papillitis and papilledema[J/OL]. J Neuroophthalmol, 2021, 41(4): e711-e712[2021-12-01]. https://pubmed.ncbi.nlm.nih.gov/33417415/. DOI: 10.1097/WNO.0000000000001159.
41. Weng CY, Khimani KS, Foroozan R, et al. A sticky situation[J]. Surv Ophthalmol, 2018, 63(5): 736-744. DOI: 10.1016/j.survophthal.2018.04.004.
42. Katz B, Hoyt WF. Gaze-evoked amaurosis from vitreopapillary traction[J]. Am J Ophthalmol, 2005, 139(4): 631-637. DOI: 10.1016/j.ajo.2004.10.045.
43. Chan JW, Liu H, Ma EL, et al. Peripapillary vitreous traction syndrome: expanding the spectrum of anterior optic neuropathies[J]. J Neuroophthalmol, 2023, 43(4): 514-519. DOI: 10.1097/WNO.0000000000001874.
44. Houle E, Miller NR. Bilateral vitreopapillary traction demonstrated by optical coherence tomography mistaken for papilledema[J/OL]. Case Rep Ophthalmol, 2012, 2012: 682659[2012-10-04]. https://pubmed.ncbi.nlm.nih.gov/23091763/. DOI: 10.1155/2012/682659.
45. Romano MR, Comune C, Ferrara M, et al. Retinal changes induced by epiretinal tangential forces[J/OL]. J Ophthalmol, 2015, 2015: 372564[2015-09-03]. https://pubmed.ncbi.nlm.nih.gov/26421183/. DOI: 10.1155/2015/372564.
46. Wong A, Kokolakis P, Rodriguez A, et al. The role of optical coherence tomography raster imaging as a valuable diagnostic tool in the differential between optic disc hemorrhage and vitreopapillary traction[J]. Mil Med, 2012, 177(11): 1374-1381. DOI: 10.7205/milmed-d-12-00148.
47. 何娜, 廖丁莹, 郑玉萍, 等. 糖尿病性黄斑水肿与玻璃体视乳头牵引的相关性分析[J]. 西部医学, 2016, 28(10): 1393-1396. DOI: 10.3969/j.issn.1672-3511.2016.10.014.He N, Liao DY, Zheng YP, et al. Correlation analysis between diabetic macular edema and vitreopapillary traction[J]. Med J West China, 2016, 28(10): 1393-1396. DOI: 10.3969/j.issn.1672-3511.2016.10.014.
48. Kim YW, Jeoung JW, Yu HG. Vitreopapillary traction in eyes with idiopathic epiretinal membrane: a spectral-domain optical coherence tomography study[J]. Ophthalmology, 2014, 121(10): 1976-1982. DOI: 10.1016/j.ophtha.2014.04.011.
49. Simonett JM, Winges KM. Vitreopapillary traction detected by optical coherence tomography[J/OL]. JAMA Ophthalmol, 2018, 136(5): e180727[2018-05-10]. https://pubmed.ncbi.nlm.nih.gov/29800255/. DOI: 10.1001/jamaophthalmol.2018.0727.
50. Cabrera S, Katz A, Margalit E. Vitreopapillary traction: cost-effective diagnosis by optical coherence tomography[J]. Can J Ophthalmol, 2006, 41(6): 763-765. DOI: 10.3129/i06-073.
51. Chang LK, Fine HF, Spaide RF, et al. Ultrastructural correlation of spectral-domain optical coherence tomographic findings in vitreomacular traction syndrome[J]. Am J Ophthalmol, 2008, 146(1): 121-127. DOI: 10.1016/j.ajo.2008.03.001.
52. Mehta A, Park SC, Liebmann JM, et al. Arcuate scotoma associated with traction at the optic disc[J]. Eye (Lond), 2013, 27(4): 572-574. DOI: 10.1038/eye.2013.21.
53. KOÇ F, Kahrman HG, Orduyilmaz. Vitreopapillary Tractions[J]. Current Retina, 2018: 244-248. DOI: 10.37783/crj-0100.
54. Spaide RF, Fujimoto JG, Waheed NK. Optical coherence tomography angiography[J]. Prog Retin Eye Res, 2018, 64: 1-55. DOI: 10.1016/j.preteyeres.2017.11.003.
55. Hagag AM, Huang D. Optical coherence tomography angiography in neuro-ophthalmology[J]. J Neuroophthalmol, 2017, 37(4): 355-357. DOI: 10.1097/WNO.0000000000000584.
56. Douglas VP, Douglas KAA, Torun N. Optical coherence tomography angiography in neuro-ophthalmology[J]. Curr Opin Ophthalmol, 2023, 34(4): 354-360. DOI: 10.1097/ICU.0000000000000955.
57. Waheed NK, Rosen RB, Jia Y, et al. Optical coherence tomography angiography in diabetic retinopathy[J/OL]. Prog Retin Eye Res, 2023, 97: 101206[2023-07-26]. https://pubmed.ncbi.nlm.nih.gov/37499857/. DOI: 10.1016/j.preteyeres.2023.101206.
58. Modarres M, Sanjari MS, Falavarjani KG. Vitrectomy and release of presumed epipapillary vitreous traction for treatment of nonarteritic anterior ischemic optic neuropathy associated with partial posterior vitreous detachment[J]. Ophthalmology, 2007, 114(2): 340-344. DOI: 10.1016/j.ophtha.2006.07.063.
59. Thompson AC, Bhatti MT, Gospe SM 3rd. Spectral-domain optical coherence tomography of the vitreopapillary interface in acute nonarteritic anterior ischemic optic neuropathy[J]. Am J Ophthalmol, 2018, 195: 199-208. DOI: 10.1016/j.ajo.2018.08.002.
60. Hwang YH, Kim YY. Peripapillary retinal nerve fiber layer thickening associated with vitreopapillary traction[J]. Semin Ophthalmol, 2015, 30(2): 136-138. DOI: 10.3109/08820538.2013.833257.
61. 中华医学会眼科学分会神经眼科学组. 中国糖尿病视神经病变诊断和治疗专家共识(2022年)[J]. 中华眼科杂志, 2022, 58(6): 405-411. DOI: 10.3760/cma.j.cn112142-20211221-00593.Neuro-ophthalmology Group of Ophthalmology Branch of Chinese Medical Association. Chinese expert consensus on diagnosis and treatment of diabetic optic neuropathy (2022)[J]. Chin J Ophthalmol, 2022, 58(6): 405-411. DOI: 10.3760/cma.j.cn112142-20211221-00593.
62. Becker KN, Nichols J. Review of diabetic papillitis[J/OL]. Dis Mon, 2021, 67(5): 101141[2021-02-03]. https://pubmed.ncbi.nlm.nih.gov/33549309/. DOI: 10.1016/j.disamonth.2021.101141.
63. Saito Y, Ueki N, Hamanaka N, et al. Transient optic disc edema by vitreous traction in a quiescent eye with proliferative diabetic retinopathy mimicking diabetic papillopathy[J]. Retina, 2005, 25(1): 83-84. DOI: 10.1097/00006982-200501000-00013.
64. Xie JS, Donaldson L, Margolin E. Papilledema: a review of etiology, pathophysiology, diagnosis, and management[J]. Surv Ophthalmol, 2022, 67(4): 1135-1159. DOI: 10.1016/j.survophthal.2021.11.007.
65. Cunha LP, Costa-Cunha LVF, Costa CF, et al. Ultrastructural changes detected using swept-source optical coherence tomography in severe vitreopapillary traction: a case report[J]. Arq Bras Oftalmol, 2019, 82(6): 517-521. DOI: 10.5935/0004-2749.20190099.
66. Nomura Y, Tamaki Y, Yanagi Y. Vitreopapillary traction diagnosed by spectral domain optical coherence tomography[J]. Ophthalmic Surg Lasers Imaging, 2010, 41(Suppl): S74-76. DOI: 10.3928/15428877-20101031-16.
67. Aras C, Arici C, Akova N. Peripapillary serous retinal detachment preceding complete posterior vitreous detachment[J]. Graefe's Arch Clin Exp Ophthalmol, 2008, 246(6): 927-929. DOI: 10.1007/s00417-008-0776-9.
68. Stefansson E. Physiology of vitreous surgery[J]. Graefe's Arch Clin Exp Ophthalmol, 2009, 247(2): 147-163. DOI: 10.1007/s00417-008-0980-7.
69. Sebag J. The vitreoretinal interface and its role in the pathogenesis of vitreomaculopathies[J]. Ophtalmol, 2015, 112(1): 10-19. DOI: 10.1007/s00347-014-3048-6.
70. Romano MR, Vallejo-Garcia JL, Camesasca FI, et al. Vitreo-papillary adhesion as a prognostic factor in pseudo- and lamellar macular holes[J]. Eye (Lond), 2012, 26(6): 810-815. DOI: 10.1038/eye.2012.43.
71. Bottós J, Elizalde J, Arevalo JF, et al. Vitreomacular traction syndrome[J]. J Ophthalmic Vis Res, 2012, 7(2): 148-161.
72. Neffendorf JE, Kirthi V, Pringle E. Ocriplasmin for symptomatic vitreomacular adhesion[J/OL]. Cochrane Database Syst Rev, 2017, 10(10): CD011874[2017-10-17]. https://pubmed.ncbi.nlm.nih.gov/29040800/. DOI: 10.1002/14651858.CD011874.pub2.
73. Cereda MG, Preziosa C, DʼAgostino I, et al. Ocriplasmin for vitreomacular traction: looking outside the macula: a wide-field optical coherence tomography study[J]. Retina, 2018, 38(8): 1541-1548. DOI: 10.1097/IAE.0000000000001785.
74. NAGEha CK, Rishi P, Rishi E. Vitrectomy for vitreopapillary traction in a nondiabetic 16-year-old girl[J]. Oman J Ophthalmol, 2017, 10(1): 38-39. DOI: 10.4103/0974-620X.200697.
75. Meyer CH, Schmidt JC, Mennel S, et al. Functional and anatomical results of vitreopapillary traction after vitrectomy[J]. Acta Ophthalmol Scand, 2007, 85(2): 221-222. DOI: 10.1111/j.1600-0420.2006.00792.x.

Chinese Journal of Ocular Fundus Diseases

Latest ArticlesResearch progress of diabetic vitreopapillary traction syndrome

Abstract Full text Figures/Tables Video References Cited by

Format

Content