• Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
LIU Chuntao, Email: taosen666@vip.163.com
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Objective To explore the diagnostic value of fractional exhaled nitric oxide (FeNO) in adult asthma.Methods PubMed, Embase, Cochrane Library, Wanfang, CNKI and VIP databases were searched for relevant literatures from the time of database establishment to February 2021. Data analysis were made by Revman and Stata.Results A total of 44 articles with 47 records and 9654 subjects were included. The diagnosis sensitivity, specificity, positive and negative predictive value of FeNO were 0.71 (95%CI 0.65 - 0.76), 0.80 (95%CI 0.75 - 0.84), 3.47 (95%CI 2.86 - 4.21), and 0.37 (95%CI 0.31 - 0.43), respectively. The diagnostic odds ratio was 9.49 (95%CI 7.13 - 12.61), and the area under the receiver operating characteristic curve was 0.82 (95%CI 0.79 - 0.85).Conclusions FeNO has certain diagnostic value in diagnosis of asthma. Types of asthma, region and cut-off value all have impact on the diagnostic efficiency of FeNO.

Citation: LI Yi'na, LIU Chuntao. Diagnostic value of exhaled nitric oxide in adult asthma: a systemic review and meta-analysis. Chinese Journal of Respiratory and Critical Care Medicine, 2021, 20(6): 416-423. doi: 10.7507/1671-6205.202105010 Copy

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